Prognostic Value of Ki67 Expression After Short-Term Presurgical Endocrine Therapy for Primary Breast Cancer

Tumor expression of the proliferation antigen Ki67 is widely used to assess the prognosis of cancer patients. A change in the expression of Ki67 after short-term exposure of patients to therapeutic agents is frequently used as a pharmacodynamic marker of efficacy, particularly among breast cancer pa...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2007-01, Vol.99 (2), p.167-170
Hauptverfasser:	Dowsett, Mitch, Smith, Ian E., Ebbs, Stephen R., Dixon, J. Michael, Skene, Anthony, A'Hern, Roger, Salter, Janine, Detre, Simone, Hills, Margaret, Walsh, Geraldine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis of Variance Antigens Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - surgery Chemotherapy, Adjuvant Disease-Free Survival Endocrine system Endocrine therapy Female Follow-Up Studies Gene expression Gynecology. Andrology. Obstetrics Humans Ki-67 Antigen - analysis Ki-67 Antigen - metabolism Mammary gland diseases Medical prognosis Medical sciences Middle Aged Multivariate Analysis Neoadjuvant Therapy - methods Neoplasms, Hormone-Dependent - chemistry Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - immunology Neoplasms, Hormone-Dependent - surgery Nitriles - administration & dosage Oncology Predictive Value of Tests Prognosis Proportional Hazards Models Receptors, Estrogen - analysis Sample Size Tamoxifen - administration & dosage Triazoles - administration & dosage Tumors
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