Analysis of the utility of diffusion-weighted MRI and apparent diffusion coefficient values in distinguishing central nervous system toxoplasmosis from lymphoma
Toxoplasmosis and lymphoma are common lesions of the central nervous system in patients with AIDS. It is often difficult to distinguish between these lesions both clinically and radiographically. Previous research has demonstrated restricted diffusion within cerebral lymphomas and bacterial abscesse...
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description | Toxoplasmosis and lymphoma are common lesions of the central nervous system in patients with AIDS. It is often difficult to distinguish between these lesions both clinically and radiographically. Previous research has demonstrated restricted diffusion within cerebral lymphomas and bacterial abscesses. However, little work has been done to evaluate the diffusion characteristics of toxoplasmosis lesions. This study was designed to explore further the utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps and values in making the distinction between toxoplasmosis and lymphoma.
The magnetic resonance imaging (MRI) studies of 36 patients, including 22 with toxoplasmosis (all of whom had AIDS) and 14 with lymphoma (8 of whom had AIDS), at two institutions were reviewed retrospectively. The characteristics of the lesions on DWI were evaluated, and the ADC ratios of the lesions were calculated and compared.
There was significant overlap of the ADC ratios of toxoplasma and lymphoma, most notably in the intermediate (1.0-1.6) range. There was variability in ADC ratios even among different lesions in the same patient. In only a minority of the lymphoma patients were the ADC ratios low enough to suggest the correct diagnosis.
Our study showed that toxoplasmosis exhibits a wide spectrum of diffusion characteristics with ADC ratios which have significant overlap with those of lymphoma. Therefore, in the majority of patients, ADC ratios are not definitive in making the distinction between toxoplasmosis and lymphoma. |
doi_str_mv | 10.1007/s00234-006-0123-y |
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The magnetic resonance imaging (MRI) studies of 36 patients, including 22 with toxoplasmosis (all of whom had AIDS) and 14 with lymphoma (8 of whom had AIDS), at two institutions were reviewed retrospectively. The characteristics of the lesions on DWI were evaluated, and the ADC ratios of the lesions were calculated and compared.
There was significant overlap of the ADC ratios of toxoplasma and lymphoma, most notably in the intermediate (1.0-1.6) range. There was variability in ADC ratios even among different lesions in the same patient. In only a minority of the lymphoma patients were the ADC ratios low enough to suggest the correct diagnosis.
Our study showed that toxoplasmosis exhibits a wide spectrum of diffusion characteristics with ADC ratios which have significant overlap with those of lymphoma. Therefore, in the majority of patients, ADC ratios are not definitive in making the distinction between toxoplasmosis and lymphoma.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-006-0123-y</identifier><identifier>PMID: 16947010</identifier><identifier>CODEN: NRDYAB</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; AIDS-Related Opportunistic Infections - diagnosis ; Biological and medical sciences ; Brain Neoplasms - diagnosis ; Diagnosis, Differential ; Diffusion ; Diffusion Magnetic Resonance Imaging ; Eye ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lymphoma ; Lymphoma - diagnosis ; Medical diagnosis ; Medical sciences ; Miscellaneous ; Nervous system ; Perception ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiology ; Radionuclide investigations ; Reproducibility of Results ; Retrospective Studies ; Toxoplasmosis, Cerebral - diagnosis</subject><ispartof>Neuroradiology, 2006-10, Vol.48 (10), p.715-720</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-3621368084c2c9b47d7bde80c17e9130a367be0f7baf087c5914f88cc0e74ed33</citedby><cites>FETCH-LOGICAL-c422t-3621368084c2c9b47d7bde80c17e9130a367be0f7baf087c5914f88cc0e74ed33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18204639$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16947010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHROEDER, Paul C</creatorcontrib><creatorcontrib>DONOVAN POST, M. Judith</creatorcontrib><creatorcontrib>OSCHATZ, Elizabeth</creatorcontrib><creatorcontrib>STADLER, Alfred</creatorcontrib><creatorcontrib>BRUCE-GREGORIOS, Jocelyn</creatorcontrib><creatorcontrib>THURNHER, Majda M</creatorcontrib><title>Analysis of the utility of diffusion-weighted MRI and apparent diffusion coefficient values in distinguishing central nervous system toxoplasmosis from lymphoma</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><description>Toxoplasmosis and lymphoma are common lesions of the central nervous system in patients with AIDS. It is often difficult to distinguish between these lesions both clinically and radiographically. Previous research has demonstrated restricted diffusion within cerebral lymphomas and bacterial abscesses. However, little work has been done to evaluate the diffusion characteristics of toxoplasmosis lesions. This study was designed to explore further the utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps and values in making the distinction between toxoplasmosis and lymphoma.
The magnetic resonance imaging (MRI) studies of 36 patients, including 22 with toxoplasmosis (all of whom had AIDS) and 14 with lymphoma (8 of whom had AIDS), at two institutions were reviewed retrospectively. The characteristics of the lesions on DWI were evaluated, and the ADC ratios of the lesions were calculated and compared.
There was significant overlap of the ADC ratios of toxoplasma and lymphoma, most notably in the intermediate (1.0-1.6) range. There was variability in ADC ratios even among different lesions in the same patient. In only a minority of the lymphoma patients were the ADC ratios low enough to suggest the correct diagnosis.
Our study showed that toxoplasmosis exhibits a wide spectrum of diffusion characteristics with ADC ratios which have significant overlap with those of lymphoma. Therefore, in the majority of patients, ADC ratios are not definitive in making the distinction between toxoplasmosis and lymphoma.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Diffusion</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Eye</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymphoma</subject><subject>Lymphoma - diagnosis</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Nervous system</subject><subject>Perception</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiology</subject><subject>Radionuclide investigations</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Toxoplasmosis, Cerebral - diagnosis</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkd-K1TAQxoso7nH1AbyRIOhddfLnNO3lsqy6sCKIXoc0TfZkSZuaSVf7Nj6qKefAAa-Gme83w8d8VfWawgcKID8iAOOiBmhqoIzX65NqRwVnNe0YPK12RW5r3gm4qF4gPgAAl1w-ry5o0wkJFHbV36tJhxU9kuhIPliyZB98Xrd28M4t6ONU_7b-_pDtQL5-vyV6GoieZ53slM8MMdE6543fpo86LBaJn4qO2U_3i8dDKcQUNelAJpse44IEV8x2JDn-iXPQOMbNiUtxJGEd50Mc9cvqmdMB7atTvax-frr5cf2lvvv2-fb66q42grFc84ZR3rTQCsNM1ws5yH6wLRgqbUc5aN7I3oKTvXbQSrPvqHBtawxYKezA-WX1_nh3TvFXMZ_V6NHYEPRki1PVtB1tGWzg2__Ah7ik8kVUjFG253tJC0SPkEkRMVmn5uRHnVZFQW3ZqWN2qmSntuzUWnbenA4v_WiH88YprAK8OwEajQ4u6cl4PHPFnmh4x_8B_walvA</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>SCHROEDER, Paul C</creator><creator>DONOVAN POST, M. 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Judith ; OSCHATZ, Elizabeth ; STADLER, Alfred ; BRUCE-GREGORIOS, Jocelyn ; THURNHER, Majda M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-3621368084c2c9b47d7bde80c17e9130a367be0f7baf087c5914f88cc0e74ed33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Diffusion</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Eye</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymphoma</topic><topic>Lymphoma - diagnosis</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Nervous system</topic><topic>Perception</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiology</topic><topic>Radionuclide investigations</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Toxoplasmosis, Cerebral - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHROEDER, Paul C</creatorcontrib><creatorcontrib>DONOVAN POST, M. 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Judith</au><au>OSCHATZ, Elizabeth</au><au>STADLER, Alfred</au><au>BRUCE-GREGORIOS, Jocelyn</au><au>THURNHER, Majda M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the utility of diffusion-weighted MRI and apparent diffusion coefficient values in distinguishing central nervous system toxoplasmosis from lymphoma</atitle><jtitle>Neuroradiology</jtitle><addtitle>Neuroradiology</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>48</volume><issue>10</issue><spage>715</spage><epage>720</epage><pages>715-720</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><coden>NRDYAB</coden><abstract>Toxoplasmosis and lymphoma are common lesions of the central nervous system in patients with AIDS. It is often difficult to distinguish between these lesions both clinically and radiographically. Previous research has demonstrated restricted diffusion within cerebral lymphomas and bacterial abscesses. However, little work has been done to evaluate the diffusion characteristics of toxoplasmosis lesions. This study was designed to explore further the utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps and values in making the distinction between toxoplasmosis and lymphoma.
The magnetic resonance imaging (MRI) studies of 36 patients, including 22 with toxoplasmosis (all of whom had AIDS) and 14 with lymphoma (8 of whom had AIDS), at two institutions were reviewed retrospectively. The characteristics of the lesions on DWI were evaluated, and the ADC ratios of the lesions were calculated and compared.
There was significant overlap of the ADC ratios of toxoplasma and lymphoma, most notably in the intermediate (1.0-1.6) range. There was variability in ADC ratios even among different lesions in the same patient. In only a minority of the lymphoma patients were the ADC ratios low enough to suggest the correct diagnosis.
Our study showed that toxoplasmosis exhibits a wide spectrum of diffusion characteristics with ADC ratios which have significant overlap with those of lymphoma. Therefore, in the majority of patients, ADC ratios are not definitive in making the distinction between toxoplasmosis and lymphoma.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16947010</pmid><doi>10.1007/s00234-006-0123-y</doi><tpages>6</tpages></addata></record> |
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subjects | Acquired immune deficiency syndrome AIDS AIDS-Related Opportunistic Infections - diagnosis Biological and medical sciences Brain Neoplasms - diagnosis Diagnosis, Differential Diffusion Diffusion Magnetic Resonance Imaging Eye Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Lymphoma Lymphoma - diagnosis Medical diagnosis Medical sciences Miscellaneous Nervous system Perception Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiology Radionuclide investigations Reproducibility of Results Retrospective Studies Toxoplasmosis, Cerebral - diagnosis |
title | Analysis of the utility of diffusion-weighted MRI and apparent diffusion coefficient values in distinguishing central nervous system toxoplasmosis from lymphoma |
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