The extended arms of DNA-binding domains: a tale of tails

DNA-binding domains (DBDs) frequently have N- or C-terminal tails, rich in lysine and/or arginine and disordered in free solution, that bind the DNA separately from and in the opposite groove to the folded domain. Is their role simply to increase affinity for DNA or do they have a role in specificit...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2006-10, Vol.31 (10), p.547-552
Hauptverfasser:	Crane-Robinson, Colyn, Dragan, Anatoly I., Privalov, Peter L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites - genetics DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Models, Molecular Molecular Sequence Data Protein Binding Protein Structure, Tertiary Thermodynamics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!