Correlation of glypican-1 expression with TGF-β, BMP, and activin receptors in pancreatic ductal adenocarcinoma

Glypican1 (GPC1) is a cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family. GPC1 plays a role in pancreatic cancer by regulating growth factor responsiveness. In view of the importance of members of the...

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Veröffentlicht in:	International journal of oncology 2006-11, Vol.29 (5), p.1139-1148
Hauptverfasser:	KAYED, Hany, KLEEFF, Jörg, KELEG, Shereen, XIAOHUA JIANG, PENZEL, Roland, GIESE, Thomas, ZENTGRAF, Hanswalter, BÜCHLER, Markus W, KORC, Murray, FRIESS, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors - analysis Activin Receptors - genetics Activin Receptors - metabolism Adult Aged Aged, 80 and over Biological and medical sciences Bone Morphogenetic Protein Receptors - analysis Bone Morphogenetic Protein Receptors - genetics Bone Morphogenetic Protein Receptors - metabolism Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Down-Regulation Female Gastroenterology. Liver. Pancreas. Abdomen Glypicans - analysis Glypicans - genetics Glypicans - metabolism Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Neoplasm Staging Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology RNA, Messenger - analysis RNA, Messenger - metabolism Signal Transduction Transforming Growth Factor beta - analysis Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Tumors
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