A 20-Mb region of chromosome 4 controls TNF-alpha-mediated CD8+ T cell aggression toward beta cells in type 1 diabetes

Identification of candidate genes and their immunological mechanisms that control autoaggressive T cells in inflamed environments, may lead to novel therapies for autoimmune diseases, like type 1 diabetes (T1D). In this study, we used transgenic NOD mice that constitutively express TNF-alpha in thei...

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Veröffentlicht in:	The Journal of immunology (1950) 2006-10, Vol.177 (8), p.5105-5114
Hauptverfasser:	Chamberlain, Giselle, Wållberg, Maja, Rainbow, Dan, Hunter, Kara, Wicker, Linda S, Green, E Allison
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Antigen Presentation - immunology CD8-Positive T-Lymphocytes - immunology Chromosomes - immunology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - pathology Immune Tolerance - genetics Immunity, Innate - genetics Insulin-Secreting Cells - immunology Mice Mice, Inbred NOD Mice, Transgenic T-Lymphocytes, Cytotoxic - immunology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology
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