Magnetic resonance imaging of viral particle biodistribution in vivo

We describe here a technique for the visualization of viral vector delivery by magnetic resonance imaging (MRI) in vivo . By conjugating avidin-coated baculoviral vectors (Baavi) with biotinylated ultra-small superparamagnetic iron oxide particles (USPIO), we are able to produce vector-related MRI c...

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Veröffentlicht in:	Gene therapy 2006-10, Vol.13 (20), p.1440-1446
Hauptverfasser:	Räty, J K, Liimatainen, T, Wirth, T, Airenne, K J, Ihalainen, T O, Huhtala, T, Hamerlynck, E, Vihinen-Ranta, M, Närvänen, A, Ylä-Herttuala, S, Hakumäki, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Avidin Baculoviridae - genetics Baculoviridae - ultrastructure Baculovirus beta-Galactosidase - genetics Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Biotechnology Brain Brain - virology Cell Biology Choroid plexus Ferric Compounds Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic Therapy - methods Genetic transformation Genetic vectors Genetic Vectors - administration & dosage Health. Pharmaceutical industry Human Genetics Identification and classification Industrial applications and implications. Economical aspects Iron compounds Iron oxides Magnetic Resonance Imaging Medical sciences Methods Nanoparticles Nanotechnology Neuroimaging NMR Nuclear magnetic resonance original-article Rats Rodents Tissue Distribution Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vectors (Biology) Ventricle (lateral) Virology β-Galactosidase
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