STructure of Peptide Sex Pheromone Receptor PrgX and PrgX/Pheromone Complexes and Regulation of Conjugation in Enterococcus faecalis

Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production of antibiotics, are controlled by intercellular signaling using small molecules. To date, understanding of the molecular mechanisms of peptide-mediated cell-cell signaling has been limit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-12, Vol.102 (51), p.18596-18601
Hauptverfasser:	Ke Shi, Brown, C. Kent, Zu-Yi Gu, Briana K. Kozlowicz, Dunny, Gary M., Douglas H. Ohlendorf, Cathleen A. Earhart, Greenberg, E. Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Amino acids ANTIBIOTICS Base Sequence BASIC BIOLOGICAL SCIENCES Binding sites Biological Sciences Conjugation, Genetic - physiology Crystallography Crystallography, X-Ray Crystals Deoxyribonucleic acid Dimerization Dimers DNA DNA, Bacterial - chemistry DNA, Bacterial - metabolism Enterococcus faecalis Enterococcus faecalis - chemistry Enterococcus faecalis - physiology GENES GENETICS Microbiology Models, Molecular Molecular Sequence Data MOLECULAR STRUCTURE Molecules Monomers national synchrotron light source Nucleic Acid Conformation OPENINGS Operons PEPTIDES PHEROMONE Pheromones PLASMIDS PRODUCTION Protein Binding Protein Structure, Quaternary PROTEINS Receptors, Pheromone - chemistry Receptors, Pheromone - metabolism REGULATIONS Sex Attractants - chemistry Sex Attractants - metabolism VIRULENCE
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