The surprising complexity of signal sequences

Most secreted and many membrane proteins contain cleavable N-terminal signal sequences that mediate their targeting to and translocation across the endoplasmic reticulum or bacterial cytoplasmic membrane. Recent studies have identified many exceptions to the widely held view that signal sequences ar...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2006-10, Vol.31 (10), p.563-571
Hauptverfasser:	Hegde, Ramanujan S., Bernstein, Harris D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endoplasmic Reticulum - metabolism Humans Membrane Proteins - chemistry Membrane Proteins - metabolism Membrane Proteins - physiology Models, Biological Protein Conformation Protein Processing, Post-Translational - physiology Protein Sorting Signals - physiology Protein Transport - physiology
Online-Zugang:	Volltext
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