Requirement of Tryptophan Hydroxylase During Development for Maturation of Sensorimotor Gating
Deficits in sensorimotor gating, a function to focus on the most salient stimulus, could lead to a breakdown of cognitive integrity, and could reflect the “flooding” by sensory overload and cognitive fragmentation seen in schizophrenia. Sensorimotor gating emerges at infancy, and matures during chil...
Gespeichert in:
| Veröffentlicht in: | Journal of molecular biology 2006-10, Vol.363 (2), p.345-354 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 354 |
|---|---|
| container_issue | 2 |
| container_start_page | 345 |
| container_title | Journal of molecular biology |
| container_volume | 363 |
| creator | Nakamura, Kazuhiro Koyama, Yoshimasa Takahashi, Kazumi Tsurui, Hiromichi Xiu, Yan Ohtsuji, Mareki Lin, Qing Shun Sugawara, Yuko Sawabe, Keiko Ohashi, Akiko Ohnuma, Tohru Arai, Heii Nishimura, Hiroyuki Hasegawa, Hiroyuki Hirose, Sachiko |
| description | Deficits in sensorimotor gating, a function to focus on the most salient stimulus, could lead to a breakdown of cognitive integrity, and could reflect the “flooding” by sensory overload and cognitive fragmentation seen in schizophrenia. Sensorimotor gating emerges at infancy, and matures during childhood. The mechanisms that underlie its development are largely unclear. Here, we screened the mouse genome, and found that tryptophan hydroxylase (TPH) is implicated in the maturation of sensorimotor gating. TPH, an enzyme involved in the biosynthesis of serotonin, proved to be required only during the weaning period for maturation of sensorimotor gating, but was dispensable for its emergence. Proper serotonin levels during development underlie the mature functional architecture for sensorimotor gating
via appropriate actin polymerization. Thus, maintaining proper serotonin levels during childhood may be important for mature sensorimotor gating in adulthood. |
| doi_str_mv | 10.1016/j.jmb.2006.08.051 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68915332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022283606010904</els_id><sourcerecordid>19381945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-41016abc023d4360e0041bee208f033ab3ba0d0b56f54dca2bcae9b05bc109213</originalsourceid><addsrcrecordid>eNqFkV1r2zAUhkXZWNJ2P6A3xVe7s3f0YU-mVyVpm0FGoe1uJyT5OHOwLUeyy_LvqyyB3m1XAul5X3SeQ8gVhYwCLb5us21nMgZQZCAzyOkZmVOQZSoLLj-QOQBjKZO8mJHzELYAkHMhP5EZLcpvJZViTn494W5qPHbYj4mrkxe_H0Y3_NZ9stpX3v3Ztzpgspx802-SJb5i64a_cO188kOPk9dj4_pD9hn74HzTuTE-PcTrfnNJPta6Dfj5dF6Qn_d3L4tVun58-L64XadWCDmm4jCONhYYrwQvAAEENYgMZA2ca8ONhgpMXtS5qKxmxmosDeTGUigZ5Rfky7F38G43YRhV1wSLbat7dFNQhSxpzjn7L0hLLmkp8gjSI2i9C8FjrYY4mvZ7RUEdvqu2KtpXB_sKpIr2Y-b6VD6ZDqv3xEl3BG6OAEYXrw16FWyDvcUqrsCOqnLNP-rfABi3lqY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19381945</pqid></control><display><type>article</type><title>Requirement of Tryptophan Hydroxylase During Development for Maturation of Sensorimotor Gating</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Nakamura, Kazuhiro ; Koyama, Yoshimasa ; Takahashi, Kazumi ; Tsurui, Hiromichi ; Xiu, Yan ; Ohtsuji, Mareki ; Lin, Qing Shun ; Sugawara, Yuko ; Sawabe, Keiko ; Ohashi, Akiko ; Ohnuma, Tohru ; Arai, Heii ; Nishimura, Hiroyuki ; Hasegawa, Hiroyuki ; Hirose, Sachiko</creator><creatorcontrib>Nakamura, Kazuhiro ; Koyama, Yoshimasa ; Takahashi, Kazumi ; Tsurui, Hiromichi ; Xiu, Yan ; Ohtsuji, Mareki ; Lin, Qing Shun ; Sugawara, Yuko ; Sawabe, Keiko ; Ohashi, Akiko ; Ohnuma, Tohru ; Arai, Heii ; Nishimura, Hiroyuki ; Hasegawa, Hiroyuki ; Hirose, Sachiko</creatorcontrib><description>Deficits in sensorimotor gating, a function to focus on the most salient stimulus, could lead to a breakdown of cognitive integrity, and could reflect the “flooding” by sensory overload and cognitive fragmentation seen in schizophrenia. Sensorimotor gating emerges at infancy, and matures during childhood. The mechanisms that underlie its development are largely unclear. Here, we screened the mouse genome, and found that tryptophan hydroxylase (TPH) is implicated in the maturation of sensorimotor gating. TPH, an enzyme involved in the biosynthesis of serotonin, proved to be required only during the weaning period for maturation of sensorimotor gating, but was dispensable for its emergence. Proper serotonin levels during development underlie the mature functional architecture for sensorimotor gating
via appropriate actin polymerization. Thus, maintaining proper serotonin levels during childhood may be important for mature sensorimotor gating in adulthood.</description><identifier>ISSN: 0022-2836</identifier><identifier>EISSN: 1089-8638</identifier><identifier>DOI: 10.1016/j.jmb.2006.08.051</identifier><identifier>PMID: 16979184</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>5-HT ; Acoustic Stimulation ; actin ; Actins - metabolism ; Animals ; Cell Line ; Cognition - physiology ; Critical Period (Psychology) ; Electroencephalography ; Genome ; Lod Score ; Mice ; Mice, Inbred Strains ; Microsatellite Repeats ; Neural Inhibition - physiology ; Neurons - cytology ; Neurons - metabolism ; Phenylalanine - analogs & derivatives ; Phenylalanine - metabolism ; Polymorphism, Single-Stranded Conformational ; psychiatric disorder ; Quantitative Trait Loci ; Rats ; Rats, Wistar ; Reflex, Startle - physiology ; Schizophrenia - physiopathology ; Serotonin - metabolism ; Tryptophan Hydroxylase - genetics ; Tryptophan Hydroxylase - metabolism</subject><ispartof>Journal of molecular biology, 2006-10, Vol.363 (2), p.345-354</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-41016abc023d4360e0041bee208f033ab3ba0d0b56f54dca2bcae9b05bc109213</citedby><cites>FETCH-LOGICAL-c448t-41016abc023d4360e0041bee208f033ab3ba0d0b56f54dca2bcae9b05bc109213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmb.2006.08.051$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16979184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Kazuhiro</creatorcontrib><creatorcontrib>Koyama, Yoshimasa</creatorcontrib><creatorcontrib>Takahashi, Kazumi</creatorcontrib><creatorcontrib>Tsurui, Hiromichi</creatorcontrib><creatorcontrib>Xiu, Yan</creatorcontrib><creatorcontrib>Ohtsuji, Mareki</creatorcontrib><creatorcontrib>Lin, Qing Shun</creatorcontrib><creatorcontrib>Sugawara, Yuko</creatorcontrib><creatorcontrib>Sawabe, Keiko</creatorcontrib><creatorcontrib>Ohashi, Akiko</creatorcontrib><creatorcontrib>Ohnuma, Tohru</creatorcontrib><creatorcontrib>Arai, Heii</creatorcontrib><creatorcontrib>Nishimura, Hiroyuki</creatorcontrib><creatorcontrib>Hasegawa, Hiroyuki</creatorcontrib><creatorcontrib>Hirose, Sachiko</creatorcontrib><title>Requirement of Tryptophan Hydroxylase During Development for Maturation of Sensorimotor Gating</title><title>Journal of molecular biology</title><addtitle>J Mol Biol</addtitle><description>Deficits in sensorimotor gating, a function to focus on the most salient stimulus, could lead to a breakdown of cognitive integrity, and could reflect the “flooding” by sensory overload and cognitive fragmentation seen in schizophrenia. Sensorimotor gating emerges at infancy, and matures during childhood. The mechanisms that underlie its development are largely unclear. Here, we screened the mouse genome, and found that tryptophan hydroxylase (TPH) is implicated in the maturation of sensorimotor gating. TPH, an enzyme involved in the biosynthesis of serotonin, proved to be required only during the weaning period for maturation of sensorimotor gating, but was dispensable for its emergence. Proper serotonin levels during development underlie the mature functional architecture for sensorimotor gating
via appropriate actin polymerization. Thus, maintaining proper serotonin levels during childhood may be important for mature sensorimotor gating in adulthood.</description><subject>5-HT</subject><subject>Acoustic Stimulation</subject><subject>actin</subject><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Cell Line</subject><subject>Cognition - physiology</subject><subject>Critical Period (Psychology)</subject><subject>Electroencephalography</subject><subject>Genome</subject><subject>Lod Score</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microsatellite Repeats</subject><subject>Neural Inhibition - physiology</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Phenylalanine - analogs & derivatives</subject><subject>Phenylalanine - metabolism</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>psychiatric disorder</subject><subject>Quantitative Trait Loci</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reflex, Startle - physiology</subject><subject>Schizophrenia - physiopathology</subject><subject>Serotonin - metabolism</subject><subject>Tryptophan Hydroxylase - genetics</subject><subject>Tryptophan Hydroxylase - metabolism</subject><issn>0022-2836</issn><issn>1089-8638</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1r2zAUhkXZWNJ2P6A3xVe7s3f0YU-mVyVpm0FGoe1uJyT5OHOwLUeyy_LvqyyB3m1XAul5X3SeQ8gVhYwCLb5us21nMgZQZCAzyOkZmVOQZSoLLj-QOQBjKZO8mJHzELYAkHMhP5EZLcpvJZViTn494W5qPHbYj4mrkxe_H0Y3_NZ9stpX3v3Ztzpgspx802-SJb5i64a_cO188kOPk9dj4_pD9hn74HzTuTE-PcTrfnNJPta6Dfj5dF6Qn_d3L4tVun58-L64XadWCDmm4jCONhYYrwQvAAEENYgMZA2ca8ONhgpMXtS5qKxmxmosDeTGUigZ5Rfky7F38G43YRhV1wSLbat7dFNQhSxpzjn7L0hLLmkp8gjSI2i9C8FjrYY4mvZ7RUEdvqu2KtpXB_sKpIr2Y-b6VD6ZDqv3xEl3BG6OAEYXrw16FWyDvcUqrsCOqnLNP-rfABi3lqY</recordid><startdate>20061020</startdate><enddate>20061020</enddate><creator>Nakamura, Kazuhiro</creator><creator>Koyama, Yoshimasa</creator><creator>Takahashi, Kazumi</creator><creator>Tsurui, Hiromichi</creator><creator>Xiu, Yan</creator><creator>Ohtsuji, Mareki</creator><creator>Lin, Qing Shun</creator><creator>Sugawara, Yuko</creator><creator>Sawabe, Keiko</creator><creator>Ohashi, Akiko</creator><creator>Ohnuma, Tohru</creator><creator>Arai, Heii</creator><creator>Nishimura, Hiroyuki</creator><creator>Hasegawa, Hiroyuki</creator><creator>Hirose, Sachiko</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20061020</creationdate><title>Requirement of Tryptophan Hydroxylase During Development for Maturation of Sensorimotor Gating</title><author>Nakamura, Kazuhiro ; Koyama, Yoshimasa ; Takahashi, Kazumi ; Tsurui, Hiromichi ; Xiu, Yan ; Ohtsuji, Mareki ; Lin, Qing Shun ; Sugawara, Yuko ; Sawabe, Keiko ; Ohashi, Akiko ; Ohnuma, Tohru ; Arai, Heii ; Nishimura, Hiroyuki ; Hasegawa, Hiroyuki ; Hirose, Sachiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-41016abc023d4360e0041bee208f033ab3ba0d0b56f54dca2bcae9b05bc109213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>5-HT</topic><topic>Acoustic Stimulation</topic><topic>actin</topic><topic>Actins - metabolism</topic><topic>Animals</topic><topic>Cell Line</topic><topic>Cognition - physiology</topic><topic>Critical Period (Psychology)</topic><topic>Electroencephalography</topic><topic>Genome</topic><topic>Lod Score</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microsatellite Repeats</topic><topic>Neural Inhibition - physiology</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Phenylalanine - analogs & derivatives</topic><topic>Phenylalanine - metabolism</topic><topic>Polymorphism, Single-Stranded Conformational</topic><topic>psychiatric disorder</topic><topic>Quantitative Trait Loci</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reflex, Startle - physiology</topic><topic>Schizophrenia - physiopathology</topic><topic>Serotonin - metabolism</topic><topic>Tryptophan Hydroxylase - genetics</topic><topic>Tryptophan Hydroxylase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Kazuhiro</creatorcontrib><creatorcontrib>Koyama, Yoshimasa</creatorcontrib><creatorcontrib>Takahashi, Kazumi</creatorcontrib><creatorcontrib>Tsurui, Hiromichi</creatorcontrib><creatorcontrib>Xiu, Yan</creatorcontrib><creatorcontrib>Ohtsuji, Mareki</creatorcontrib><creatorcontrib>Lin, Qing Shun</creatorcontrib><creatorcontrib>Sugawara, Yuko</creatorcontrib><creatorcontrib>Sawabe, Keiko</creatorcontrib><creatorcontrib>Ohashi, Akiko</creatorcontrib><creatorcontrib>Ohnuma, Tohru</creatorcontrib><creatorcontrib>Arai, Heii</creatorcontrib><creatorcontrib>Nishimura, Hiroyuki</creatorcontrib><creatorcontrib>Hasegawa, Hiroyuki</creatorcontrib><creatorcontrib>Hirose, Sachiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Kazuhiro</au><au>Koyama, Yoshimasa</au><au>Takahashi, Kazumi</au><au>Tsurui, Hiromichi</au><au>Xiu, Yan</au><au>Ohtsuji, Mareki</au><au>Lin, Qing Shun</au><au>Sugawara, Yuko</au><au>Sawabe, Keiko</au><au>Ohashi, Akiko</au><au>Ohnuma, Tohru</au><au>Arai, Heii</au><au>Nishimura, Hiroyuki</au><au>Hasegawa, Hiroyuki</au><au>Hirose, Sachiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Requirement of Tryptophan Hydroxylase During Development for Maturation of Sensorimotor Gating</atitle><jtitle>Journal of molecular biology</jtitle><addtitle>J Mol Biol</addtitle><date>2006-10-20</date><risdate>2006</risdate><volume>363</volume><issue>2</issue><spage>345</spage><epage>354</epage><pages>345-354</pages><issn>0022-2836</issn><eissn>1089-8638</eissn><abstract>Deficits in sensorimotor gating, a function to focus on the most salient stimulus, could lead to a breakdown of cognitive integrity, and could reflect the “flooding” by sensory overload and cognitive fragmentation seen in schizophrenia. Sensorimotor gating emerges at infancy, and matures during childhood. The mechanisms that underlie its development are largely unclear. Here, we screened the mouse genome, and found that tryptophan hydroxylase (TPH) is implicated in the maturation of sensorimotor gating. TPH, an enzyme involved in the biosynthesis of serotonin, proved to be required only during the weaning period for maturation of sensorimotor gating, but was dispensable for its emergence. Proper serotonin levels during development underlie the mature functional architecture for sensorimotor gating
via appropriate actin polymerization. Thus, maintaining proper serotonin levels during childhood may be important for mature sensorimotor gating in adulthood.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16979184</pmid><doi>10.1016/j.jmb.2006.08.051</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2836 |
| ispartof | Journal of molecular biology, 2006-10, Vol.363 (2), p.345-354 |
| issn | 0022-2836 1089-8638 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68915332 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 5-HT Acoustic Stimulation actin Actins - metabolism Animals Cell Line Cognition - physiology Critical Period (Psychology) Electroencephalography Genome Lod Score Mice Mice, Inbred Strains Microsatellite Repeats Neural Inhibition - physiology Neurons - cytology Neurons - metabolism Phenylalanine - analogs & derivatives Phenylalanine - metabolism Polymorphism, Single-Stranded Conformational psychiatric disorder Quantitative Trait Loci Rats Rats, Wistar Reflex, Startle - physiology Schizophrenia - physiopathology Serotonin - metabolism Tryptophan Hydroxylase - genetics Tryptophan Hydroxylase - metabolism |
| title | Requirement of Tryptophan Hydroxylase During Development for Maturation of Sensorimotor Gating |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T01%3A19%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Requirement%20of%20Tryptophan%20Hydroxylase%20During%20Development%20for%20Maturation%20of%20Sensorimotor%20Gating&rft.jtitle=Journal%20of%20molecular%20biology&rft.au=Nakamura,%20Kazuhiro&rft.date=2006-10-20&rft.volume=363&rft.issue=2&rft.spage=345&rft.epage=354&rft.pages=345-354&rft.issn=0022-2836&rft.eissn=1089-8638&rft_id=info:doi/10.1016/j.jmb.2006.08.051&rft_dat=%3Cproquest_cross%3E19381945%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19381945&rft_id=info:pmid/16979184&rft_els_id=S0022283606010904&rfr_iscdi=true |