Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin

Proteasome inhibition following DNA damage results in the synergistic induction of apoptosis via a nuclear factor-kappaB-independent mechanism. In this study, we identify the role of p53 in mediating apoptosis by the sequence-specific treatment involving the DNA-damaging, topoisomerase I-targeting d...

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Veröffentlicht in:	Molecular cancer therapeutics 2005-12, Vol.4 (12), p.1880-1890
Hauptverfasser:	Vaziri, Susan A J, Hill, Jason, Chikamori, Kenichi, Grabowski, Dale R, Takigawa, Nagio, Chawla-Sarkar, Mamta, Rybicki, Lisa R, Gudkov, Andrei V, Mekhail, Tarek, Bukowski, Ronald M, Ganapathi, Mahrukh K, Ganapathi, Ram
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - physiology Apoptosis Base Sequence Boronic Acids - pharmacology Bortezomib Cell Cycle - drug effects Cell Line, Tumor Cysteine Proteinase Inhibitors - pharmacology DNA Damage DNA Primers Down-Regulation Humans Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Neoplasm Proteins - genetics Neoplasm Proteins - physiology Proteasome Inhibitors Pyrazines - pharmacology Tumor Suppressor Protein p53 - physiology
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