A randomized, controlled trial of C0- Vs C2-guided therapeutic drug monitoring of cyclosporine in stable heart transplant patients

Cyclosporine monitoring using 2-hour post-dose samples (C2) is thought to be more efficacious than using pre-dose levels (C0) in managing immunosuppression for transplant patients. We evaluated the effect of C2 monitoring on cyclosporine dose and clinical parameters in stable heart transplant patien...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2005-12, Vol.24 (12), p.2137-2143
Hauptverfasser:	MATHIAS, Helen C, OZALP, Farük, WILL, Malcolm B, BORLAND, William, PAYNE, Carol, KERR, Myra, LOCKHART, Jane, MURDAY, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Area Under Curve Biological and medical sciences Creatinine - metabolism Cyclosporine - administration & dosage Cyclosporine - pharmacokinetics Cyclosporine - therapeutic use Female Graft Rejection Heart Transplantation Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Infection Male Medical sciences Middle Aged Monitoring, Physiologic Postoperative Complications Prospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Survival Analysis
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