Nitric Oxide Negatively Regulates Fas CD95-induced Apoptosis through Inhibition of Ubiquitin-Proteasome-mediated Degradation of FLICE Inhibitory Protein

Stimulation of cell surface Fas (CD95) results in recruitment of cytoplasmic proteins and activation of caspase-8, which in turn activates downstream effector caspases leading to programmed cell death. Nitric oxide (NO) plays a key role in the regulation of apoptosis, but its role in Fas-induced cel...

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Veröffentlicht in:	The Journal of biological chemistry 2005-12, Vol.280 (51), p.42044-42050
Hauptverfasser:	Chanvorachote, Pithi, Nimmannit, Ubonthip, Wang, Liying, Stehlik, Christian, Lu, Bin, Azad, Neelam, Rojanasakul, Yon
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Blotting, Western Caspase 8 Caspases - metabolism Cell Line Enzyme Activation fas Receptor - physiology Humans Hydrolysis Immunoprecipitation Nitric Oxide - physiology Proteasome Endopeptidase Complex - metabolism Ubiquitin - metabolism
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