Kynurenamines as Neural Nitric Oxide Synthase Inhibitors

To find new compounds with potential neuroprotective activity, we have designed, synthesized, and characterized a series of neural nitric oxide synthase (nNOS) inhibitors with a kynurenamine structure. Among them, N-[3-(2-amino-5-methoxyphenyl)-3-oxopropyl]acetamide is the main melatonin metabolite...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-12, Vol.48 (26), p.8174-8181
Hauptverfasser:	Entrena, Antonio, Camacho, M. Encarnación, Carrión, M. Dora, López-Cara, Luisa C, Velasco, Guillermo, León, Josefa, Escames, Germaine, Acuña-Castroviejo, Darío, Tapias, Víctor, Gallo, Miguel A, Vivó, Antonio, Espinosa, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Corpus Striatum - drug effects Corpus Striatum - enzymology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Kynuramine - analogs & derivatives Kynuramine - chemical synthesis Kynuramine - pharmacology Kynurenine 3-Monooxygenase - antagonists & inhibitors Medical sciences Molecular Conformation Neuropharmacology Neuroprotective agent Nitric Oxide Synthase Type I - antagonists & inhibitors Pharmacology. Drug treatments Rats
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