Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients?
Uric acid (UA) may play a pathogenetic role in hypertension and kidney disease. We explored the prevalence of hyperuricemia and the relationship of UA to graft function and hypertension in prevalent renal transplant recipients (RTR). Baseline and follow-up data were collected on 90 RTR (mean age 51...
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| Veröffentlicht in: | Transplantation 2005-12, Vol.80 (11), p.1565-1571 |
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| creator | ARMSTRONG, Kirsten A JOHNSON, David W CAMPBELL, Scott B ISBEL, Nicole M HAWLEY, Carmel M |
| description | Uric acid (UA) may play a pathogenetic role in hypertension and kidney disease. We explored the prevalence of hyperuricemia and the relationship of UA to graft function and hypertension in prevalent renal transplant recipients (RTR).
Baseline and follow-up data were collected on 90 RTR (mean age 51 yrs, 53% male, median transplant duration 7 years). Graft function was estimated using MDRD Study Equation 7.
At baseline, 70% RTR had hyperuricemia (UA >7.0 mg/dl (0.42 mmol/L) in men and >6.0 mg/dl (0.36 mmol/L) in women) compared to 80% after 2.2 years (P=0.06). UA was not associated with blood pressure (BP) level but was higher in RTR with a history of hypertension compared to those without (8.6+/-1.8 vs. 7.3+/-2.2 mg/dl, [0.51+/-0.11 vs. 0.43+/-0.13 mmol/L], P=0.003) and in RTR on > or =3 antihypertensive medications compared to those taking less (9.1+/-1.6 vs. 7.6+/-1.8 mg/dL, [0.54+/-0.1 vs. 0.45+/-0.11 mmol/L], P |
| doi_str_mv | 10.1097/01.tp.0000183895.88572.13 |
| format | Article |
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Baseline and follow-up data were collected on 90 RTR (mean age 51 yrs, 53% male, median transplant duration 7 years). Graft function was estimated using MDRD Study Equation 7.
At baseline, 70% RTR had hyperuricemia (UA >7.0 mg/dl (0.42 mmol/L) in men and >6.0 mg/dl (0.36 mmol/L) in women) compared to 80% after 2.2 years (P=0.06). UA was not associated with blood pressure (BP) level but was higher in RTR with a history of hypertension compared to those without (8.6+/-1.8 vs. 7.3+/-2.2 mg/dl, [0.51+/-0.11 vs. 0.43+/-0.13 mmol/L], P=0.003) and in RTR on > or =3 antihypertensive medications compared to those taking less (9.1+/-1.6 vs. 7.6+/-1.8 mg/dL, [0.54+/-0.1 vs. 0.45+/-0.11 mmol/L], P<0.001). A history of hypertension was independently predictive of UA (beta 0.06, [95% CI 0.02 to 0.10], P=0.007) in addition to sex, cyclosporine dose, prednisolone dose, estimated glomerular filtration rate (eGFRMDRD) and beta-blocker therapy. UA was independently predictive of follow-up eGFRMDRD (beta -22.2 [95% CI -41.2 to -3.2], P=0.02) but did not predict change in eGFRMDRD over time. UA was independently associated with requirement for antihypertensive therapy (beta 0.34, [95% CI 1.05 to 1.90], P=0.02).
Hyperuricemia is common in RTR and is associated with need for antihypertensive therapy and level of graft function.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.tp.0000183895.88572.13</identifier><identifier>PMID: 16371927</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Body Mass Index ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Cohort Studies ; Diuretics - therapeutic use ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glomerular Filtration Rate ; Humans ; Hypertension - drug therapy ; Hypertension - epidemiology ; Immunosuppressive Agents - therapeutic use ; Kidney Transplantation - pathology ; Kidney Transplantation - physiology ; Male ; Medical sciences ; Middle Aged ; Postoperative Complications - epidemiology ; Predictive Value of Tests ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Uric Acid - blood</subject><ispartof>Transplantation, 2005-12, Vol.80 (11), p.1565-1571</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-3d27775d52b563e87f5263c754f4817c588465bcd88174570d7ce4184648c923</citedby><cites>FETCH-LOGICAL-c522t-3d27775d52b563e87f5263c754f4817c588465bcd88174570d7ce4184648c923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17402202$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16371927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARMSTRONG, Kirsten A</creatorcontrib><creatorcontrib>JOHNSON, David W</creatorcontrib><creatorcontrib>CAMPBELL, Scott B</creatorcontrib><creatorcontrib>ISBEL, Nicole M</creatorcontrib><creatorcontrib>HAWLEY, Carmel M</creatorcontrib><title>Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients?</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Uric acid (UA) may play a pathogenetic role in hypertension and kidney disease. We explored the prevalence of hyperuricemia and the relationship of UA to graft function and hypertension in prevalent renal transplant recipients (RTR).
Baseline and follow-up data were collected on 90 RTR (mean age 51 yrs, 53% male, median transplant duration 7 years). Graft function was estimated using MDRD Study Equation 7.
At baseline, 70% RTR had hyperuricemia (UA >7.0 mg/dl (0.42 mmol/L) in men and >6.0 mg/dl (0.36 mmol/L) in women) compared to 80% after 2.2 years (P=0.06). UA was not associated with blood pressure (BP) level but was higher in RTR with a history of hypertension compared to those without (8.6+/-1.8 vs. 7.3+/-2.2 mg/dl, [0.51+/-0.11 vs. 0.43+/-0.13 mmol/L], P=0.003) and in RTR on > or =3 antihypertensive medications compared to those taking less (9.1+/-1.6 vs. 7.6+/-1.8 mg/dL, [0.54+/-0.1 vs. 0.45+/-0.11 mmol/L], P<0.001). A history of hypertension was independently predictive of UA (beta 0.06, [95% CI 0.02 to 0.10], P=0.007) in addition to sex, cyclosporine dose, prednisolone dose, estimated glomerular filtration rate (eGFRMDRD) and beta-blocker therapy. UA was independently predictive of follow-up eGFRMDRD (beta -22.2 [95% CI -41.2 to -3.2], P=0.02) but did not predict change in eGFRMDRD over time. UA was independently associated with requirement for antihypertensive therapy (beta 0.34, [95% CI 1.05 to 1.90], P=0.02).
Hyperuricemia is common in RTR and is associated with need for antihypertensive therapy and level of graft function.</description><subject>Adult</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Cohort Studies</subject><subject>Diuretics - therapeutic use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - epidemiology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Kidney Transplantation - pathology</subject><subject>Kidney Transplantation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications - epidemiology</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Uric Acid - blood</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2PFCEQhonRuOPoXzB40Fu3FF9Fn4xZP5NNvOydMDS9i-mhW6BN5t8v604yR7lUeOupgrwvIe-A9cAG_Migr2vP2gEjzKB6YxTyHsQzsgMlZKeZYc_JjjEJHQiBV-RVKb8brwTiS3IFWiAMHHfk-GUJhW45eup8HOm9-xuoo6ur98tdSKG2Rl7mQGOid9lNlY6nMm3J17gk6lKbOK0h15DKo9CoHJKbac0ulXV2qTbBxzWGVMun1-TF5OYS3pzrntx--3p7_aO7-fX95_Xnm84rzmsnRo6IalT8oLQIBifFtfCo5CQNoFfGSK0OfjTtJhWyEX2Q0ERp_MDFnnx4Wrvm5c8WSrXHWHyY23fCshWrzQCgtf4vCMj0wMTQwOEJ9HkpJYfJrjkeXT5ZYPYxE8vA1tVeMrH_MrHN_T15e35kOxzDeJk8h9CA92fAFe_mqVnnY7lwKBnnjIsHHCWVNQ</recordid><startdate>20051215</startdate><enddate>20051215</enddate><creator>ARMSTRONG, Kirsten A</creator><creator>JOHNSON, David W</creator><creator>CAMPBELL, Scott B</creator><creator>ISBEL, Nicole M</creator><creator>HAWLEY, Carmel M</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20051215</creationdate><title>Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients?</title><author>ARMSTRONG, Kirsten A ; JOHNSON, David W ; CAMPBELL, Scott B ; ISBEL, Nicole M ; HAWLEY, Carmel M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-3d27775d52b563e87f5263c754f4817c588465bcd88174570d7ce4184648c923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Cohort Studies</topic><topic>Diuretics - therapeutic use</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - epidemiology</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Kidney Transplantation - pathology</topic><topic>Kidney Transplantation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Complications - epidemiology</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARMSTRONG, Kirsten A</creatorcontrib><creatorcontrib>JOHNSON, David W</creatorcontrib><creatorcontrib>CAMPBELL, Scott B</creatorcontrib><creatorcontrib>ISBEL, Nicole M</creatorcontrib><creatorcontrib>HAWLEY, Carmel M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARMSTRONG, Kirsten A</au><au>JOHNSON, David W</au><au>CAMPBELL, Scott B</au><au>ISBEL, Nicole M</au><au>HAWLEY, Carmel M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients?</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2005-12-15</date><risdate>2005</risdate><volume>80</volume><issue>11</issue><spage>1565</spage><epage>1571</epage><pages>1565-1571</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Uric acid (UA) may play a pathogenetic role in hypertension and kidney disease. We explored the prevalence of hyperuricemia and the relationship of UA to graft function and hypertension in prevalent renal transplant recipients (RTR).
Baseline and follow-up data were collected on 90 RTR (mean age 51 yrs, 53% male, median transplant duration 7 years). Graft function was estimated using MDRD Study Equation 7.
At baseline, 70% RTR had hyperuricemia (UA >7.0 mg/dl (0.42 mmol/L) in men and >6.0 mg/dl (0.36 mmol/L) in women) compared to 80% after 2.2 years (P=0.06). UA was not associated with blood pressure (BP) level but was higher in RTR with a history of hypertension compared to those without (8.6+/-1.8 vs. 7.3+/-2.2 mg/dl, [0.51+/-0.11 vs. 0.43+/-0.13 mmol/L], P=0.003) and in RTR on > or =3 antihypertensive medications compared to those taking less (9.1+/-1.6 vs. 7.6+/-1.8 mg/dL, [0.54+/-0.1 vs. 0.45+/-0.11 mmol/L], P<0.001). A history of hypertension was independently predictive of UA (beta 0.06, [95% CI 0.02 to 0.10], P=0.007) in addition to sex, cyclosporine dose, prednisolone dose, estimated glomerular filtration rate (eGFRMDRD) and beta-blocker therapy. UA was independently predictive of follow-up eGFRMDRD (beta -22.2 [95% CI -41.2 to -3.2], P=0.02) but did not predict change in eGFRMDRD over time. UA was independently associated with requirement for antihypertensive therapy (beta 0.34, [95% CI 1.05 to 1.90], P=0.02).
Hyperuricemia is common in RTR and is associated with need for antihypertensive therapy and level of graft function.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>16371927</pmid><doi>10.1097/01.tp.0000183895.88572.13</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Body Mass Index Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cohort Studies Diuretics - therapeutic use Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology Glomerular Filtration Rate Humans Hypertension - drug therapy Hypertension - epidemiology Immunosuppressive Agents - therapeutic use Kidney Transplantation - pathology Kidney Transplantation - physiology Male Medical sciences Middle Aged Postoperative Complications - epidemiology Predictive Value of Tests Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Uric Acid - blood |
| title | Does uric acid have a pathogenetic role in graft dysfunction and hypertension in renal transplant recipients? |
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