Combined Merkel cell carcinoma and atypical fibroxanthoma

Although there are reports of squamous cell carcinoma arising within and adjacent to Merkel cell carcinoma, and one report of an atypical fibroxanthoma-like tumor arising in an irradiated recurrent Merkel cell carcinoma, there have previously been no reports of an immunohistochemically verified atyp...

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Veröffentlicht in:Journal of cutaneous medicine and surgery 2005-02, Vol.9 (1), p.6-9
Hauptverfasser: YOUKER, Summer R, BILLINGSLEY, Elizabeth M
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description Although there are reports of squamous cell carcinoma arising within and adjacent to Merkel cell carcinoma, and one report of an atypical fibroxanthoma-like tumor arising in an irradiated recurrent Merkel cell carcinoma, there have previously been no reports of an immunohistochemically verified atypical fibroxanthoma occurring in conjunction with a Merkel cell carcinoma. We report on a neoplasm with distinct features of both Merkel cell carcinoma and atypical fibroxanthoma. Histologic and immunohistochemical evaluations were performed. Our results verify the finding of a combined Merkel cell carcinoma and atypical fibroxanthoma. This case is an interesting and unusual combination of tumors. The origin of the Merkel cell carcinoma is revisited. Debated origins include neuroendocrine, epithelial, and pleuripotent stem cell.
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subjects Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Merkel Cell - diagnosis
Carcinoma, Merkel Cell - therapy
Dermatology
Diagnosis, Differential
Fatal Outcome
Histiocytoma, Malignant Fibrous - diagnosis
Histiocytoma, Malignant Fibrous - therapy
Humans
Immunohistochemistry
Lip Neoplasms - diagnosis
Lip Neoplasms - therapy
Male
Medical sciences
title Combined Merkel cell carcinoma and atypical fibroxanthoma
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