Cellular aspects of liver regeneration
This paper has the objective to analyze the cellular aspects of liver regeneration (LR). Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progen...
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| Veröffentlicht in: | Acta cirúrgica brasileira 2006, Vol.21 Suppl 1 (suppl 1), p.63-66 |
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| container_issue | suppl 1 |
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| container_title | Acta cirúrgica brasileira |
| container_volume | 21 Suppl 1 |
| creator | Tarlá, Marissa Rabelo Ramalho, Fernando Ramalho, Leandra Naira Zambelli Silva, Tiago de Castro e Brandão, Daniel Ferracioli Ferreira, Juliana Silva, Orlando de Castro e Zucoloto, Sérgio |
| description | This paper has the objective to analyze the cellular aspects of liver regeneration (LR). Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progenitor or a liver trunk cell was not obvious. Nowadays it is well-established that precursor cells take part in the liver regenerative process. The liver trunk cell, oval cell, acts as a by-potential precursor, contributing for the liver restoration, mainly when the hepatocytes are unable to proliferate. Another precursor, trunk cell of hematopoetic origin (HSC), takes part in the regenerative process, originating cells of the hepatocytic lineage and colangiocytes, as well as the oval cell. The way the trans-differentiation takes place is not established yet. A number of studies must be undertaken in order to clarify questions, such as the possible occurrence of cellular fusion process between the HSC and the hepatic cells and the possibility of application as a new therapeutic procedure in the treatment of diseases associated with insufficiency of this noble organ. |
| doi_str_mv | 10.1590/s0102-86502006000700015 |
| format | Article |
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A number of studies must be undertaken in order to clarify questions, such as the possible occurrence of cellular fusion process between the HSC and the hepatic cells and the possibility of application as a new therapeutic procedure in the treatment of diseases associated with insufficiency of this noble organ.</description><subject>Animals</subject><subject>Antigens, Surface - metabolism</subject><subject>Bile Ducts - cytology</subject><subject>Biomarkers - metabolism</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Proliferation</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hepatocytes - cytology</subject><subject>Humans</subject><subject>Liver Regeneration - physiology</subject><subject>Rats</subject><issn>0102-8650</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUE1LxDAQDaK46-pf0J72Vp1p0qY5SnFVWPCgnkOaTqTSL5Ot4L-3yxYVPAwzMO_Ne_MYu0K4xlTBTQCEJM6zFBKADADkVJgeseXP4vjPvGBnIbxPCJEhP2ULlIA8Rblk64KaZmyMj0wYyO5C1LuoqT_JR57eqCNvdnXfnbMTZ5pAF3NfsdfN3UvxEG-f7h-L221sOYo0RiudS5xKCASZxKJQuSozJcjmFXA7GVLSoczRVCK1kDlelpVAJ4jnkiq-YuvD3cH3HyOFnW7rYCeLpqN-DDrLFQIHPgHlAWh9H4Inpwdft8Z_aQS9j0g_77_X_yKamJezxFi2VP3y5kz4NwaDX-s</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Tarlá, Marissa Rabelo</creator><creator>Ramalho, Fernando</creator><creator>Ramalho, Leandra Naira Zambelli</creator><creator>Silva, Tiago de Castro e</creator><creator>Brandão, Daniel Ferracioli</creator><creator>Ferreira, Juliana</creator><creator>Silva, Orlando de Castro e</creator><creator>Zucoloto, Sérgio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Cellular aspects of liver regeneration</title><author>Tarlá, Marissa Rabelo ; Ramalho, Fernando ; Ramalho, Leandra Naira Zambelli ; Silva, Tiago de Castro e ; Brandão, Daniel Ferracioli ; Ferreira, Juliana ; Silva, Orlando de Castro e ; Zucoloto, Sérgio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3145-1c7ff2f92e04ea2c14989b694ec8d03c01097f1781ad45c06f3bbd41f4e387ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antigens, Surface - metabolism</topic><topic>Bile Ducts - cytology</topic><topic>Biomarkers - metabolism</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Proliferation</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hepatocytes - cytology</topic><topic>Humans</topic><topic>Liver Regeneration - physiology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tarlá, Marissa Rabelo</creatorcontrib><creatorcontrib>Ramalho, Fernando</creatorcontrib><creatorcontrib>Ramalho, Leandra Naira Zambelli</creatorcontrib><creatorcontrib>Silva, Tiago de Castro e</creatorcontrib><creatorcontrib>Brandão, Daniel Ferracioli</creatorcontrib><creatorcontrib>Ferreira, Juliana</creatorcontrib><creatorcontrib>Silva, Orlando de Castro e</creatorcontrib><creatorcontrib>Zucoloto, Sérgio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cirúrgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tarlá, Marissa Rabelo</au><au>Ramalho, Fernando</au><au>Ramalho, Leandra Naira Zambelli</au><au>Silva, Tiago de Castro e</au><au>Brandão, Daniel Ferracioli</au><au>Ferreira, Juliana</au><au>Silva, Orlando de Castro e</au><au>Zucoloto, Sérgio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular aspects of liver regeneration</atitle><jtitle>Acta cirúrgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2006</date><risdate>2006</risdate><volume>21 Suppl 1</volume><issue>suppl 1</issue><spage>63</spage><epage>66</epage><pages>63-66</pages><issn>0102-8650</issn><eissn>0102-8650</eissn><abstract>This paper has the objective to analyze the cellular aspects of liver regeneration (LR). Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progenitor or a liver trunk cell was not obvious. Nowadays it is well-established that precursor cells take part in the liver regenerative process. The liver trunk cell, oval cell, acts as a by-potential precursor, contributing for the liver restoration, mainly when the hepatocytes are unable to proliferate. Another precursor, trunk cell of hematopoetic origin (HSC), takes part in the regenerative process, originating cells of the hepatocytic lineage and colangiocytes, as well as the oval cell. The way the trans-differentiation takes place is not established yet. A number of studies must be undertaken in order to clarify questions, such as the possible occurrence of cellular fusion process between the HSC and the hepatic cells and the possibility of application as a new therapeutic procedure in the treatment of diseases associated with insufficiency of this noble organ.</abstract><cop>Brazil</cop><pmid>17013517</pmid><doi>10.1590/s0102-86502006000700015</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antigens, Surface - metabolism Bile Ducts - cytology Biomarkers - metabolism Cell Differentiation - physiology Cell Proliferation Hematopoietic Stem Cells - cytology Hepatocytes - cytology Humans Liver Regeneration - physiology Rats |
| title | Cellular aspects of liver regeneration |
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