Fluorescence in situ hybridization studies using BAC clones of the EVI1 locus in hematological malignancies with 3q rearrangements

Chromosomal rearrangements involving 3q26 are a recurrent aberration in malignant myeloid disorders. Several of these rearrangements involve the EVI1 oncogene or its surrounding sequences and are associated with a poor prognosis. Fluorescence in situ hybridization (FISH) studies using bacterial arti...

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Veröffentlicht in:	Cancer genetics and cytogenetics 2006-10, Vol.170 (2), p.115-120
Hauptverfasser:	Madrigal, Irene, Carrió, Ana, Gómez, Cándida, Rozman, María, Esteve, Jordi, Nomdedeu, Benet, Campo, Elías, Costa, Dolors
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Aberrations Chromosomes, Artificial, Bacterial Chromosomes, Human, Pair 3 DNA-Binding Proteins - genetics Gene Duplication Hematologic Neoplasms - genetics Humans In Situ Hybridization, Fluorescence MDS1 and EVI1 Complex Locus Protein Proto-Oncogenes - genetics Transcription Factors - genetics Translocation, Genetic
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