Neuroprotective effect of the peptides ADNF-9 and NAP on hypoxic–ischemic brain injury in neonatal rats

Perinatal asphyxia is an important cause of neonatal mortality and subsequent serious sequelae such as motor and cognitive deficits and seizures. Recent studies have demonstrated that short peptides derived from activity-dependent neurotrophic factor (ADNF) and activity-dependent neuroprotective pro...

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Veröffentlicht in:	Brain research 2006-10, Vol.1115 (1), p.169-178
Hauptverfasser:	Kumral, Abdullah, Yesilirmak, Didem Cemile, Sonmez, Ulker, Baskin, Huseyin, Tugyan, Kazim, Yilmaz, Osman, Genc, Sermin, Gokmen, Necati, Genc, Kursat, Duman, Nuray, Ozkan, Hasan
Format:	Artikel
Sprache:	eng
Schlagworte:	ADNF-9 Aging - drug effects Aging - physiology Animals Animals, Newborn Apoptosis - drug effects Apoptosis - physiology Asphyxia Neonatorum - drug therapy Asphyxia Neonatorum - metabolism Asphyxia Neonatorum - physiopathology Biological and medical sciences Brain Brain - drug effects Brain - metabolism Brain - pathology Brain Infarction - drug therapy Brain Infarction - physiopathology Brain Infarction - prevention & control Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - pathology Disease Models, Animal Drug Combinations Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Humans Hypoxia Hypoxia-Ischemia, Brain - drug therapy Hypoxia-Ischemia, Brain - metabolism Hypoxia-Ischemia, Brain - physiopathology Infant, Newborn Injections, Intraperitoneal Ischemia Medical sciences NAP Nerve Degeneration - drug therapy Nerve Degeneration - etiology Nerve Degeneration - prevention & control Nerve Tissue Proteins - pharmacology Nerve Tissue Proteins - therapeutic use Neurology Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Newborn Nitric oxide Nitric Oxide - biosynthesis Nitrites - metabolism Oligopeptides - pharmacology Oligopeptides - therapeutic use Pharmacology. Drug treatments Rats Rats, Wistar Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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