Ultraviolet A1 phototherapy decreases inhibitory SMAD7 gene expression in localized scleroderma

Localized scleroderma (LS) is a connective skin disease with marked sclerosis of the skin as the most prominent feature. Transforming growth factor beta (TGF-beta) plays a central role in the pathogenesis of sclerotic skin diseases. Recently, special attention was contributed to a family of transcri...

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Veröffentlicht in:	Archives of Dermatological Research 2006-11, Vol.298 (6), p.265-272
Hauptverfasser:	KREUTER, Alexander, HYUN, Julia, SKRYGAN, Marina, SOMMER, Anna, TOMI, Nordwig S, BREUCKMANN, Frank, ALTMEYER, Peter, GAMBICHLER, Thilo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Dermatology Female Gene Expression Regulation - radiation effects Humans Medical sciences Middle Aged RNA, Messenger - genetics RNA, Messenger - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Localized - metabolism Scleroderma, Localized - radiotherapy Signal Transduction - physiology Skin - metabolism Skin - pathology Smad3 Protein - genetics Smad3 Protein - metabolism Smad4 Protein - genetics Smad4 Protein - metabolism Smad7 Protein - genetics Smad7 Protein - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Ultraviolet Rays Ultraviolet Therapy - methods
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