Hemodynamic effects of sildenafil citrate (Viagra) on segmental branches of bilateral renal arteries
Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with...
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| Veröffentlicht in: | International urology and nephrology 2005-12, Vol.37 (4), p.785-789 |
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| container_title | International urology and nephrology |
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| creator | Ardicoglu, Arslan Kocakoc, Ercan Yuzgec, Veysel Bozgeyik, Zulkif Canatan, Halit Kiris, Adem |
| description | Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED.
Total of 35 male patients aging between 34 and 56 years were recruited into study. Patients were evaluated with renal color Doppler sonography (CDS) before and after (45-75 min) peroral sildenafil citrate (50 mg) administration. Peak systolic flow rate (V(max)), end diastolic flow rate (V(min)), resistive index (RI) and pulsatility index (PI) of renal artery segmental branches were determined before and after sildenafil citrate administration.
V(min) measured at right lower segment was significantly reduced after sildenafil administration (p = 0.030). Accordingly mean RI and PI of right lower segment of renal artery slightly increased after drug administration (p = 0.007 and p = 0.012, respectively). The measurements on other segments had no significant change after sildenafil treatment when compared to baseline values. On this single dose administration no side effect was recorded.
Findings of the present study demonstrated that peroral sildenafil citrate usage had slight effects on hemodynamic parameters of lower segmental branch of right renal artery. This result could not be interpreted as robust evidence for hemodynamic changes of renal arteries associated with sildenafil usage nevertheless warrants more comprehensive research with larger number of patients. |
| doi_str_mv | 10.1007/s11255-005-3621-7 |
| format | Article |
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Total of 35 male patients aging between 34 and 56 years were recruited into study. Patients were evaluated with renal color Doppler sonography (CDS) before and after (45-75 min) peroral sildenafil citrate (50 mg) administration. Peak systolic flow rate (V(max)), end diastolic flow rate (V(min)), resistive index (RI) and pulsatility index (PI) of renal artery segmental branches were determined before and after sildenafil citrate administration.
V(min) measured at right lower segment was significantly reduced after sildenafil administration (p = 0.030). Accordingly mean RI and PI of right lower segment of renal artery slightly increased after drug administration (p = 0.007 and p = 0.012, respectively). The measurements on other segments had no significant change after sildenafil treatment when compared to baseline values. On this single dose administration no side effect was recorded.
Findings of the present study demonstrated that peroral sildenafil citrate usage had slight effects on hemodynamic parameters of lower segmental branch of right renal artery. This result could not be interpreted as robust evidence for hemodynamic changes of renal arteries associated with sildenafil usage nevertheless warrants more comprehensive research with larger number of patients.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-005-3621-7</identifier><identifier>PMID: 16362600</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Adult ; Blood Flow Velocity - drug effects ; Blood Pressure - drug effects ; Humans ; Male ; Middle Aged ; Piperazines - pharmacology ; Purines ; Renal Artery - diagnostic imaging ; Renal Artery - drug effects ; Renal Artery - physiology ; Sildenafil Citrate ; Sulfones ; Ultrasonography, Doppler, Color ; Vasodilator Agents - pharmacology</subject><ispartof>International urology and nephrology, 2005-12, Vol.37 (4), p.785-789</ispartof><rights>Springer 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c241t-1197b65812414090258cba50e848512fbdc377c14204ea2b2466313ba843154d3</citedby><cites>FETCH-LOGICAL-c241t-1197b65812414090258cba50e848512fbdc377c14204ea2b2466313ba843154d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16362600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ardicoglu, Arslan</creatorcontrib><creatorcontrib>Kocakoc, Ercan</creatorcontrib><creatorcontrib>Yuzgec, Veysel</creatorcontrib><creatorcontrib>Bozgeyik, Zulkif</creatorcontrib><creatorcontrib>Canatan, Halit</creatorcontrib><creatorcontrib>Kiris, Adem</creatorcontrib><title>Hemodynamic effects of sildenafil citrate (Viagra) on segmental branches of bilateral renal arteries</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><description>Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED.
Total of 35 male patients aging between 34 and 56 years were recruited into study. Patients were evaluated with renal color Doppler sonography (CDS) before and after (45-75 min) peroral sildenafil citrate (50 mg) administration. Peak systolic flow rate (V(max)), end diastolic flow rate (V(min)), resistive index (RI) and pulsatility index (PI) of renal artery segmental branches were determined before and after sildenafil citrate administration.
V(min) measured at right lower segment was significantly reduced after sildenafil administration (p = 0.030). Accordingly mean RI and PI of right lower segment of renal artery slightly increased after drug administration (p = 0.007 and p = 0.012, respectively). The measurements on other segments had no significant change after sildenafil treatment when compared to baseline values. On this single dose administration no side effect was recorded.
Findings of the present study demonstrated that peroral sildenafil citrate usage had slight effects on hemodynamic parameters of lower segmental branch of right renal artery. This result could not be interpreted as robust evidence for hemodynamic changes of renal arteries associated with sildenafil usage nevertheless warrants more comprehensive research with larger number of patients.</description><subject>Adult</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Piperazines - pharmacology</subject><subject>Purines</subject><subject>Renal Artery - diagnostic imaging</subject><subject>Renal Artery - drug effects</subject><subject>Renal Artery - physiology</subject><subject>Sildenafil Citrate</subject><subject>Sulfones</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE1LHEEQhpsQiavmB3iRxoMkh9Gq_preYxDjBha8qNemp6dGe5mPtXv24L9Pm10QciqqeN6i6mHsHOEaAeqbjCi0rgB0JY3Aqv7CFqhrWQlt1Ve2AAlYoRHymJ3kvAGApQX4xo7RFN4ALFi7omFq30c_xMCp6yjMmU8dz7FvafRd7HmIc_Iz8R_P0b8k_5NPI8_0MtA4-543yY_hlf6FmtgXMJVpKtme-1S6SPmMHXW-z_T9UE_Z0--7x9tVtX64_3P7a10FoXCuEJd1Y7TF0ilYQvkiNF4DWWU1iq5pg6zrgEqAIi8aoYyRKBtvlUStWnnKrvZ7t2l621Ge3RBzoL73I0277IxdghaABbz8D9xMu1ROzk6gQautVgXCPRTSlHOizm1THHx6dwjuw7_b-3fFv_vw7-qSuTgs3jUDtZ-Jg3D5Fxhufrs</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Ardicoglu, Arslan</creator><creator>Kocakoc, Ercan</creator><creator>Yuzgec, Veysel</creator><creator>Bozgeyik, Zulkif</creator><creator>Canatan, Halit</creator><creator>Kiris, Adem</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200512</creationdate><title>Hemodynamic effects of sildenafil citrate (Viagra) on segmental branches of bilateral renal arteries</title><author>Ardicoglu, Arslan ; Kocakoc, Ercan ; Yuzgec, Veysel ; Bozgeyik, Zulkif ; Canatan, Halit ; Kiris, Adem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-1197b65812414090258cba50e848512fbdc377c14204ea2b2466313ba843154d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Piperazines - pharmacology</topic><topic>Purines</topic><topic>Renal Artery - diagnostic imaging</topic><topic>Renal Artery - drug effects</topic><topic>Renal Artery - physiology</topic><topic>Sildenafil Citrate</topic><topic>Sulfones</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ardicoglu, Arslan</creatorcontrib><creatorcontrib>Kocakoc, Ercan</creatorcontrib><creatorcontrib>Yuzgec, Veysel</creatorcontrib><creatorcontrib>Bozgeyik, Zulkif</creatorcontrib><creatorcontrib>Canatan, Halit</creatorcontrib><creatorcontrib>Kiris, Adem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ardicoglu, Arslan</au><au>Kocakoc, Ercan</au><au>Yuzgec, Veysel</au><au>Bozgeyik, Zulkif</au><au>Canatan, Halit</au><au>Kiris, Adem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemodynamic effects of sildenafil citrate (Viagra) on segmental branches of bilateral renal arteries</atitle><jtitle>International urology and nephrology</jtitle><addtitle>Int Urol Nephrol</addtitle><date>2005-12</date><risdate>2005</risdate><volume>37</volume><issue>4</issue><spage>785</spage><epage>789</epage><pages>785-789</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED.
Total of 35 male patients aging between 34 and 56 years were recruited into study. Patients were evaluated with renal color Doppler sonography (CDS) before and after (45-75 min) peroral sildenafil citrate (50 mg) administration. Peak systolic flow rate (V(max)), end diastolic flow rate (V(min)), resistive index (RI) and pulsatility index (PI) of renal artery segmental branches were determined before and after sildenafil citrate administration.
V(min) measured at right lower segment was significantly reduced after sildenafil administration (p = 0.030). Accordingly mean RI and PI of right lower segment of renal artery slightly increased after drug administration (p = 0.007 and p = 0.012, respectively). The measurements on other segments had no significant change after sildenafil treatment when compared to baseline values. On this single dose administration no side effect was recorded.
Findings of the present study demonstrated that peroral sildenafil citrate usage had slight effects on hemodynamic parameters of lower segmental branch of right renal artery. This result could not be interpreted as robust evidence for hemodynamic changes of renal arteries associated with sildenafil usage nevertheless warrants more comprehensive research with larger number of patients.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>16362600</pmid><doi>10.1007/s11255-005-3621-7</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Blood Flow Velocity - drug effects Blood Pressure - drug effects Humans Male Middle Aged Piperazines - pharmacology Purines Renal Artery - diagnostic imaging Renal Artery - drug effects Renal Artery - physiology Sildenafil Citrate Sulfones Ultrasonography, Doppler, Color Vasodilator Agents - pharmacology |
| title | Hemodynamic effects of sildenafil citrate (Viagra) on segmental branches of bilateral renal arteries |
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