SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans

Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2005-12, Vol.310 (5755), p.1782-1786
Hauptverfasser:	Lamason, Rebecca L, Mohideen, Manzoor-Ali P.K, Mest, Jason R, Wong, Andrew C, Norton, Heather L, Aros, Michele C, Jurynec, Michael J, Mao, Xianyun, Humphreville, Vanessa R, Humbert, Jasper E, Sinha, Soniya, Moore, Jessica L, Jagadeeswaran, Pudur, Zhao, Wei, Ning, Gang, Makalowska, Izabela, McKeigue, Paul M, O'Donnell, David, Kittles, Rick, Parra, Esteban J, Mangini, Nancy J, Grunwald, David J, Shriver, Mark D, Canfield, Victor A, Cheng, Keith C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults African Americans - genetics African Continental Ancestry Group - genetics Alanine - genetics Alleles Amino Acid Sequence Analysis Animal coloration Animal colouration Animals Antiporters - chemistry Antiporters - genetics Antiporters - physiology Asian Continental Ancestry Group - genetics Biological and medical sciences Biological Evolution Calcium Calcium - metabolism Coding Color of animals Danio rerio Embryos European Continental Ancestry Group - genetics Fish Freshwater Fundamental and applied biological sciences. Psychology Gene Frequency Genes Genetic mutation Genetic research Genetic Variation Genetics Haplotypes Heterozygote Humans Ion Transport Larvae Melanin Melanins - analysis Melanophores Melanosomes Melanosomes - chemistry Melanosomes - ultrastructure Mice Molecular Sequence Data Multifactorial Inheritance Mutation Pigment Epithelium of Eye - chemistry Pigment Epithelium of Eye - ultrastructure Pigmentation Pigments Polymorphism Polymorphism, Single Nucleotide Research Article Selection, Genetic Skin Pigmentation - genetics Threonine - genetics Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue Visual Acuity Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - chemistry Zebrafish Proteins - genetics Zebrafish Proteins - physiology
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