Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

Bortezomib (Velcade, formerly known as PS-341) is a boronic acid dipeptide derivative that is a selective and potent inhibitor of the proteasome. We hypothesized that proteasome inhibition would lead to an accumulation of misfolded proteins in the cell resulting in endoplasmic reticulum (ER) stress....

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-12, Vol.65 (24), p.11510-11519
Hauptverfasser:	NAWROCKI, Steffan T, CAREW, Jennifer S, DUNNER, Kenneth JR, BOISE, Lawrence H, CHIAO, Paul J, PENG HUANG, ABBRUZZESE, James L, MCCONKEY, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Boronic Acids - pharmacology Bortezomib Calcium - metabolism Caspase Inhibitors Caspases - genetics Caspases - metabolism Caspases, Initiator Chemotherapy Cycloheximide - pharmacology eIF-2 Kinase - antagonists & inhibitors eIF-2 Kinase - metabolism Endoplasmic Reticulum - metabolism Gastroenterology. Liver. Pancreas. Abdomen Heat-Shock Proteins - metabolism Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Molecular Chaperones - metabolism Oxidative Stress Pancreas - drug effects Pancreas - metabolism Pancreas - pathology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pharmacology. Drug treatments Phosphorylation - drug effects Protein Biosynthesis - drug effects Protein Processing, Post-Translational Pyrazines - pharmacology RNA, Small Interfering - pharmacology Thapsigargin - pharmacology Transcription Factor CHOP - metabolism Tumors Ubiquitin - metabolism
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