The Neural Correlates of Anhedonia in Major Depressive Disorder

Anhedonia is a relative lack of pleasure in response to formerly rewarding stimuli. It is an important diagnostic feature of major depressive disorder (MDD), and predicts antidepressant efficacy. Understanding its neurobiological basis may help to target new treatments and predict treatment outcomes...

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Veröffentlicht in:Biological psychiatry (1969) 2005-12, Vol.58 (11), p.843-853
Hauptverfasser: Keedwell, Paul A., Andrew, Chris, Williams, Steven C.R., Brammer, Mick J., Phillips, Mary L.
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container_end_page 853
container_issue 11
container_start_page 843
container_title Biological psychiatry (1969)
container_volume 58
creator Keedwell, Paul A.
Andrew, Chris
Williams, Steven C.R.
Brammer, Mick J.
Phillips, Mary L.
description Anhedonia is a relative lack of pleasure in response to formerly rewarding stimuli. It is an important diagnostic feature of major depressive disorder (MDD), and predicts antidepressant efficacy. Understanding its neurobiological basis may help to target new treatments and predict treatment outcomes. Using a novel paradigm, we aimed to explore the correlations between anhedonia severity and magnitude of neural responses to happy and sad stimuli in regions previously implicated in studies of human reward processing and depressive anhedonia. Neural responses to happy and sad emotional stimuli (autobiographical prompts and mood congruent facial expressions) were measured using blood oxygen level dependent (BOLD) functional magnetic resonance imaging in twelve MDD individuals with varying degrees of anhedonia. In response to happy stimuli, anhedonia, but not depression severity per se, was positively and negatively correlated with ventromedial prefrontal cortex (VMPFC) and amygdala/ventral striatal activity, respectively. State anxiety independently contributed to a VMPFC-subcortical dissociation of response to happy (but not sad) stimuli, which was similar, but different, to anhedonia. These findings suggest that anhedonia and state anxiety are associated with dysfunction within neural systems underlying the response to, and assessment of, the rewarding potential of emotive stimuli in MDD, and highlight the importance of employing a symptom-dimension-based approach in the examination of the neurobiology of depression.
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State anxiety independently contributed to a VMPFC-subcortical dissociation of response to happy (but not sad) stimuli, which was similar, but different, to anhedonia. 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subjects Adult
Adult and adolescent clinical studies
Affect - physiology
Anxiety - physiopathology
Biological and medical sciences
Brain Mapping
Depression
Depressive Disorder, Major - pathology
Depressive Disorder, Major - psychology
Echo-Planar Imaging
Female
fMRI
Happiness
Humans
Magnetic Resonance Imaging
Major depression
Male
Medical sciences
Memory
Middle Aged
Mood disorders
mood induction
Neostriatum - pathology
prefrontal cortex
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reward
striatum
title The Neural Correlates of Anhedonia in Major Depressive Disorder
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