Reduction in brain infarction by augmentation of central histaminergic activity in rats

Inflammation is a factor in the aggravation of reperfusion injury after cerebral ischemia. Since histamine H 2 receptor stimulation suppresses inflammatory reactions, effects of the central histaminergic activation on brain infarction were examined in rats. Focal cerebral ischemia for 2 h was provok...

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Veröffentlicht in:	Brain research 2005-12, Vol.1066 (1), p.172-178
Hauptverfasser:	Motoki, Atsuko, Adachi, Naoto, Semba, Kazunori, Liu, Keyue, Arai, Tatsuru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cerebral Infarction - prevention & control Cerebral ischemia Extracellular Space - drug effects Extracellular Space - metabolism H 3 receptor Histamine Histamine - metabolism Histamine - physiology Histamine Antagonists - pharmacology Histamine- N-methyltransferase Histidine Histidine - pharmacology Male Medical sciences Neurology Piperidines - pharmacology Pyrimethamine - analogs & derivatives Pyrimethamine - pharmacology Rat Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system
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