Differentiation of androgen-independent prostate cancer PC-3 cells is associated with increased nuclear factor-kappaB activity

Recently, we have reported that inosine 5'-monophosphate dehydrogenase inhibitors, such as mycophenolic acid (MPA), induce the differentiation of PC-3 cells, which are derived from a human androgen-independent prostate cancer, into cells with a phenotype resembling maturing prostate secretory c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-12, Vol.65 (24), p.11588-11596
Hauptverfasser:	Floryk, Daniel, Huberman, Eliezer
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - physiology Antibiotics, Antineoplastic - pharmacology Apigenin - pharmacology Apoptosis - drug effects Biological Transport - drug effects Calcium Channel Blockers - pharmacology Cell Differentiation - drug effects Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Cytoplasm - metabolism Drug Therapy, Combination Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Gene Expression Regulation, Neoplastic - drug effects Humans Male Mycophenolic Acid - pharmacology Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism NF-kappa B - genetics NF-kappa B - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Transfection Vacuoles - metabolism
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