Viability and function of 8-day-stored apheresis platelets
BACKGROUND: Methods of bacterial detection and pathogen inactivation of platelets (PLTs) may allow extended storage of PLTs as long as PLT quality is maintained. STUDY DESIGN AND METHODS: Twenty normal volunteers had their PLTs collected with an apheresis machine (Haemonetics Corp.). A variety of in...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2006-10, Vol.46 (10), p.1763-1769 |
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| creator | Slichter, Sherrill J. Bolgiano, Doug Jones, Mary Kay Christoffel, Todd Corson, Jill Rose, Leslie Foley, Jim Popovsky, Mark Baril, Laurene L. Corda, Tammy Dincecco, Dorothy M. Snyder, Edward L. |
| description | BACKGROUND: Methods of bacterial detection and pathogen inactivation of platelets (PLTs) may allow extended storage of PLTs as long as PLT quality is maintained.
STUDY DESIGN AND METHODS: Twenty normal volunteers had their PLTs collected with an apheresis machine (Haemonetics Corp.). A variety of in vitro PLT function and metabolic assays were performed both on Day 0 and after 8 days of storage. On Day 8, a small blood sample was drawn from each donor to obtain fresh PLTs. The fresh and stored autologous PLTs were labeled with either 51Cr or 111In, and the radiolabeled PLTs were transfused. Posttransfusion serial blood samples were drawn to determine the relative posttransfusion recoveries and survivals of the fresh versus the stored PLTs.
RESULTS: Although the in vitro assays showed some differences between the two trial sites, the results were generally within the ranges expected for fresh and stored PLTs. Overall, PLT recoveries averaged 66 ± 16 percent versus 53 ± 20 percent and survivals averaged 8.5 ± 1.6 days versus 5.6 ± 1.6 days, respectively, for fresh compared to 8‐day‐stored PLTs. There were no significant differences in the in vivo PLT data between the trial sites or based on the radiolabel used for the measurements.
CONCLUSION: After 8 days of storage, the in vivo posttransfusion recovery and survival of autologous Haemonetics apheresis PLTs meet the proposed standards for poststorage PLT quality. |
| doi_str_mv | 10.1111/j.1537-2995.2006.00970.x |
| format | Article |
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STUDY DESIGN AND METHODS: Twenty normal volunteers had their PLTs collected with an apheresis machine (Haemonetics Corp.). A variety of in vitro PLT function and metabolic assays were performed both on Day 0 and after 8 days of storage. On Day 8, a small blood sample was drawn from each donor to obtain fresh PLTs. The fresh and stored autologous PLTs were labeled with either 51Cr or 111In, and the radiolabeled PLTs were transfused. Posttransfusion serial blood samples were drawn to determine the relative posttransfusion recoveries and survivals of the fresh versus the stored PLTs.
RESULTS: Although the in vitro assays showed some differences between the two trial sites, the results were generally within the ranges expected for fresh and stored PLTs. Overall, PLT recoveries averaged 66 ± 16 percent versus 53 ± 20 percent and survivals averaged 8.5 ± 1.6 days versus 5.6 ± 1.6 days, respectively, for fresh compared to 8‐day‐stored PLTs. There were no significant differences in the in vivo PLT data between the trial sites or based on the radiolabel used for the measurements.
CONCLUSION: After 8 days of storage, the in vivo posttransfusion recovery and survival of autologous Haemonetics apheresis PLTs meet the proposed standards for poststorage PLT quality.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2006.00970.x</identifier><identifier>PMID: 17002633</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood coagulation. Blood cells ; Blood Platelets - cytology ; Blood Preservation - methods ; Blood Preservation - standards ; Blood Transfusion, Autologous - methods ; Blood Transfusion, Autologous - standards ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Molecular and cellular biology ; Platelet ; Platelet Transfusion - methods ; Platelet Transfusion - standards ; Plateletpheresis - methods ; Plateletpheresis - standards ; Time Factors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2006-10, Vol.46 (10), p.1763-1769</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4360-867c75a725f42f250b1a1fa62203d72108c51538188c3d7499ecf82846aad433</citedby><cites>FETCH-LOGICAL-c4360-867c75a725f42f250b1a1fa62203d72108c51538188c3d7499ecf82846aad433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2006.00970.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2006.00970.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18209348$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17002633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slichter, Sherrill J.</creatorcontrib><creatorcontrib>Bolgiano, Doug</creatorcontrib><creatorcontrib>Jones, Mary Kay</creatorcontrib><creatorcontrib>Christoffel, Todd</creatorcontrib><creatorcontrib>Corson, Jill</creatorcontrib><creatorcontrib>Rose, Leslie</creatorcontrib><creatorcontrib>Foley, Jim</creatorcontrib><creatorcontrib>Popovsky, Mark</creatorcontrib><creatorcontrib>Baril, Laurene L.</creatorcontrib><creatorcontrib>Corda, Tammy</creatorcontrib><creatorcontrib>Dincecco, Dorothy M.</creatorcontrib><creatorcontrib>Snyder, Edward L.</creatorcontrib><title>Viability and function of 8-day-stored apheresis platelets</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Methods of bacterial detection and pathogen inactivation of platelets (PLTs) may allow extended storage of PLTs as long as PLT quality is maintained.
STUDY DESIGN AND METHODS: Twenty normal volunteers had their PLTs collected with an apheresis machine (Haemonetics Corp.). A variety of in vitro PLT function and metabolic assays were performed both on Day 0 and after 8 days of storage. On Day 8, a small blood sample was drawn from each donor to obtain fresh PLTs. The fresh and stored autologous PLTs were labeled with either 51Cr or 111In, and the radiolabeled PLTs were transfused. Posttransfusion serial blood samples were drawn to determine the relative posttransfusion recoveries and survivals of the fresh versus the stored PLTs.
RESULTS: Although the in vitro assays showed some differences between the two trial sites, the results were generally within the ranges expected for fresh and stored PLTs. Overall, PLT recoveries averaged 66 ± 16 percent versus 53 ± 20 percent and survivals averaged 8.5 ± 1.6 days versus 5.6 ± 1.6 days, respectively, for fresh compared to 8‐day‐stored PLTs. There were no significant differences in the in vivo PLT data between the trial sites or based on the radiolabel used for the measurements.
CONCLUSION: After 8 days of storage, the in vivo posttransfusion recovery and survival of autologous Haemonetics apheresis PLTs meet the proposed standards for poststorage PLT quality.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Platelets - cytology</subject><subject>Blood Preservation - methods</subject><subject>Blood Preservation - standards</subject><subject>Blood Transfusion, Autologous - methods</subject><subject>Blood Transfusion, Autologous - standards</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Platelet</subject><subject>Platelet Transfusion - methods</subject><subject>Platelet Transfusion - standards</subject><subject>Plateletpheresis - methods</subject><subject>Plateletpheresis - standards</subject><subject>Time Factors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFP2zAUxy00BF3hK0y5wC3h2U5sZwckhAZDQkzaKlpxsV4dW3OXJsVOtfbbz6UVXOeLn-zf-_v5R0hGoaBpXS0KWnGZs7quCgYgCoBaQrE5IqP3i09kBFDSnFLOTsnnGBcAwGqgJ-SUylQKzkfk67PHuW_9sM2wazK37szg-y7rXabyBrd5HPpgmwxXv22w0cds1eJgWzvEM3LssI32_LCPyeTu2-T2e_744_7h9uYxNyUXkCshjaxQssqVzLEK5hSpQ8EY8EYyCspUaWhFlTLpoKxra5xiqhSITcn5mFzuY1ehf13bOOilj8a2LXa2X0ctVJ1-z6sEqj1oQh9jsE6vgl9i2GoKeqdNL_TOjt7Z0Ttt-k2b3qTWL4c31vOlbT4aD54ScHEAMBpsXcDO-PjBKZZGKFXirvfcX9_a7X8PoCc_797KFJDvA3wc7OY9AMMfLSSXlZ4-3euZ-DWdwexFl_wfHnSV1A</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Slichter, Sherrill J.</creator><creator>Bolgiano, Doug</creator><creator>Jones, Mary Kay</creator><creator>Christoffel, Todd</creator><creator>Corson, Jill</creator><creator>Rose, Leslie</creator><creator>Foley, Jim</creator><creator>Popovsky, Mark</creator><creator>Baril, Laurene L.</creator><creator>Corda, Tammy</creator><creator>Dincecco, Dorothy M.</creator><creator>Snyder, Edward L.</creator><general>Blackwell Publishing Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200610</creationdate><title>Viability and function of 8-day-stored apheresis platelets</title><author>Slichter, Sherrill J. ; Bolgiano, Doug ; Jones, Mary Kay ; Christoffel, Todd ; Corson, Jill ; Rose, Leslie ; Foley, Jim ; Popovsky, Mark ; Baril, Laurene L. ; Corda, Tammy ; Dincecco, Dorothy M. ; Snyder, Edward L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4360-867c75a725f42f250b1a1fa62203d72108c51538188c3d7499ecf82846aad433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Platelets - cytology</topic><topic>Blood Preservation - methods</topic><topic>Blood Preservation - standards</topic><topic>Blood Transfusion, Autologous - methods</topic><topic>Blood Transfusion, Autologous - standards</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Platelet</topic><topic>Platelet Transfusion - methods</topic><topic>Platelet Transfusion - standards</topic><topic>Plateletpheresis - methods</topic><topic>Plateletpheresis - standards</topic><topic>Time Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slichter, Sherrill J.</creatorcontrib><creatorcontrib>Bolgiano, Doug</creatorcontrib><creatorcontrib>Jones, Mary Kay</creatorcontrib><creatorcontrib>Christoffel, Todd</creatorcontrib><creatorcontrib>Corson, Jill</creatorcontrib><creatorcontrib>Rose, Leslie</creatorcontrib><creatorcontrib>Foley, Jim</creatorcontrib><creatorcontrib>Popovsky, Mark</creatorcontrib><creatorcontrib>Baril, Laurene L.</creatorcontrib><creatorcontrib>Corda, Tammy</creatorcontrib><creatorcontrib>Dincecco, Dorothy M.</creatorcontrib><creatorcontrib>Snyder, Edward L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slichter, Sherrill J.</au><au>Bolgiano, Doug</au><au>Jones, Mary Kay</au><au>Christoffel, Todd</au><au>Corson, Jill</au><au>Rose, Leslie</au><au>Foley, Jim</au><au>Popovsky, Mark</au><au>Baril, Laurene L.</au><au>Corda, Tammy</au><au>Dincecco, Dorothy M.</au><au>Snyder, Edward L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viability and function of 8-day-stored apheresis platelets</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2006-10</date><risdate>2006</risdate><volume>46</volume><issue>10</issue><spage>1763</spage><epage>1769</epage><pages>1763-1769</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Methods of bacterial detection and pathogen inactivation of platelets (PLTs) may allow extended storage of PLTs as long as PLT quality is maintained.
STUDY DESIGN AND METHODS: Twenty normal volunteers had their PLTs collected with an apheresis machine (Haemonetics Corp.). A variety of in vitro PLT function and metabolic assays were performed both on Day 0 and after 8 days of storage. On Day 8, a small blood sample was drawn from each donor to obtain fresh PLTs. The fresh and stored autologous PLTs were labeled with either 51Cr or 111In, and the radiolabeled PLTs were transfused. Posttransfusion serial blood samples were drawn to determine the relative posttransfusion recoveries and survivals of the fresh versus the stored PLTs.
RESULTS: Although the in vitro assays showed some differences between the two trial sites, the results were generally within the ranges expected for fresh and stored PLTs. Overall, PLT recoveries averaged 66 ± 16 percent versus 53 ± 20 percent and survivals averaged 8.5 ± 1.6 days versus 5.6 ± 1.6 days, respectively, for fresh compared to 8‐day‐stored PLTs. There were no significant differences in the in vivo PLT data between the trial sites or based on the radiolabel used for the measurements.
CONCLUSION: After 8 days of storage, the in vivo posttransfusion recovery and survival of autologous Haemonetics apheresis PLTs meet the proposed standards for poststorage PLT quality.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17002633</pmid><doi>10.1111/j.1537-2995.2006.00970.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - cytology Blood Preservation - methods Blood Preservation - standards Blood Transfusion, Autologous - methods Blood Transfusion, Autologous - standards Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Female Fundamental and applied biological sciences. Psychology Humans Intensive care medicine Male Medical sciences Molecular and cellular biology Platelet Platelet Transfusion - methods Platelet Transfusion - standards Plateletpheresis - methods Plateletpheresis - standards Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Viability and function of 8-day-stored apheresis platelets |
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