Comparative inflammatory properties of staphylococcal superantigenic enterotoxins SEA and SEG: implications for septic shock

The severity of Staphylococcus aureus sepsis is positively associated with staphylococcal enterotoxin A (SEA) and negatively associated with the enterotoxin gene cluster (egc), which encodes five staphylococcal enterotoxins [1]. We postulated that the variable, clinical severity of S. aureus sepsis...

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Veröffentlicht in:	Journal of leukocyte biology 2006-10, Vol.80 (4), p.753-758
Hauptverfasser:	Dauwalder, Olivier, Thomas, Damien, Ferry, Tristan, Debard, Anne‐Lise, Badiou, Cédric, Vandenesch, François, Etienne, Jerome, Lina, Gerard, Monneret, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD - drug effects Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - drug effects bacterial Chemokine CCL3 Chemokine CCL4 chemokines cytokines Dose-Response Relationship, Drug Enterotoxins - immunology Enterotoxins - pharmacology Humans Inflammation - immunology Lectins, C-Type Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Macrophage Inflammatory Proteins - biosynthesis Shock, Septic - immunology Staphylococcus aureus Structure-Activity Relationship superantigens Superantigens - immunology Superantigens - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - immunology Th1 Cells - drug effects Th1 Cells - immunology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - drug effects
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