Prevalence of anti human herpes virus-6 IgG and its receptor in acute leukemia (membrane cofactor protein: MCP, CD46)

CD46 is a membrane cofactor protein, which acts as a cofactor for factor I proteolytic cleavage of C3, so it protects the cells expressing it on their surface from autologous complement attack. It has been recently described as a receptor for HHV-6. Also, it has been shown to be highly expressed on...

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Veröffentlicht in:Journal of Egyptian National Cancer Institute 2005-03, Vol.17 (1), p.29-34
Hauptverfasser: Assem, Magda M, Gad, Walaa H, El-Sharkawy, Nahla M, El-Rouby, Mahmoud N, Ghaleb, Fayek M, Tarek, Hala, Kamel, Azza M
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container_end_page 34
container_issue 1
container_start_page 29
container_title Journal of Egyptian National Cancer Institute
container_volume 17
creator Assem, Magda M
Gad, Walaa H
El-Sharkawy, Nahla M
El-Rouby, Mahmoud N
Ghaleb, Fayek M
Tarek, Hala
Kamel, Azza M
description CD46 is a membrane cofactor protein, which acts as a cofactor for factor I proteolytic cleavage of C3, so it protects the cells expressing it on their surface from autologous complement attack. It has been recently described as a receptor for HHV-6. Also, it has been shown to be highly expressed on malignant cells as compared to normal cells, thus playing a major role by which these cells, either cells of haematological malignancy or cells of other body cancers, can protect themselves against complement attack so they can survive and metastasize. This study has been done to detect the seroprevalence of HHV-6 among 47 Egyptian adult cases of acute leukemia using the anti-HHV-6 IgG ELISA serological technique. CD46 receptor expression and immunophenotyping technique were performed using FCM. Twenty nine of the cases were ANLL, while 18 were ALL cases. Sixteen age- and sex-matched control cases were also studied for both anti-HHV-6 IgG and CD46 receptor expression. HHV-6 IgG antibodies were encountered in 29 (100%), 14 (77.8%) and 12 (75%) of the ANLL, ALL and the control group, cases, respectively. CD46 expression was encountered in 21 (72.4%) of the ANLL cases and in 10 (55.6%) of the ALL cases. Concordance between HHV- 6 seropositivity and CD46 expression was encountered in 31 cases (29 positive and 2 negative). Disconcordance was encountered in 16 cases with 14 showing HHV-6 IgG seropositivity with no CD46 expression and 2 showing the reverse. The lack of significant correlation between CD46 expression and seropositivity would exclude CD46 expression as a cause of contracting HHV-6 infection in leukemic patients.
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subjects Acute Disease
Adolescent
Adult
Aged
Antibodies, Viral - blood
Egypt
Female
Herpesvirus 6, Human - immunology
Humans
Immunoglobulin G - blood
Leukemia - virology
Male
Membrane Cofactor Protein - analysis
Middle Aged
Seroepidemiologic Studies
title Prevalence of anti human herpes virus-6 IgG and its receptor in acute leukemia (membrane cofactor protein: MCP, CD46)
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