Endothelin-1 as a central mediator of LPS-induced fever in rats

Fever induced by E. coli lipopolysaccharide (LPS) in rats is substantially reduced by blockade of central endothelin ET B receptors. This study explores the role of endothelin-1 as a central mediator of fever in rats, by investigating the effect of a pyrogenic dose of LPS on the levels of big endoth...

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Veröffentlicht in:	Brain research 2005-12, Vol.1066 (1), p.92-100
Hauptverfasser:	Fabricio, Aline S.C., Rae, Giles A., D'Orléans-Juste, Pedro, Souza, Glória E.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Big endothelin-1 Biological and medical sciences Body Temperature - drug effects Cerebrospinal fluid Endothelin-1 Endothelin-1 - cerebrospinal fluid Endothelin-1 - metabolism Endothelin-1 - pharmacology Endothelin-1 - physiology Escherichia coli Fever Fever - chemically induced Fever - physiopathology Fundamental and applied biological sciences. Psychology Hypothalamus Injections, Intravenous Lipopolysaccharide Lipopolysaccharides Male Microinjections Oligopeptides - pharmacology Piperidines - pharmacology Preoptic area Preoptic Area - physiology Rats Rats, Wistar Skin Temperature - drug effects Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems
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