Prostate cancer progression into androgen independency is associated with alterations in cell adhesion and invasivity
Background Mortality in prostate cancer is primarily due to failure to cure hormone refractory patients with metastatic disease. The present study focused on elucidating alterations in invasive properties, which are connected with progression into androgen independency. Methods Ability to grow witho...
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| Veröffentlicht in: | Prostate 2006-11, Vol.66 (15), p.1631-1640 |
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| creator | Jennbacken, Karin Gustavsson, Heléne Welén, Karin Vallbo, Christina Damber, Jan-Erik |
| description | Background
Mortality in prostate cancer is primarily due to failure to cure hormone refractory patients with metastatic disease. The present study focused on elucidating alterations in invasive properties, which are connected with progression into androgen independency.
Methods
Ability to grow without anchor, migration, cell adhesion properties and expression of invasive factors were investigated in LNCaP and its androgen‐independent subline LNCaP‐19. Also, invasive capacity into blood vessels was examined in subcutaneous tumors.
Results
Transition into an androgen‐independent state was associated with ability to grow without anchor, increased migration, and alterations in cell adhesion properties. The tumor suppressor E‐cadherin was downregulated and the proinvasive factors N‐cadherin, MMP‐9, and membrane type 1 (MT1)‐MMP were upregulated in LNCaP‐19. In addition, LNCaP‐19 displayed a markedly increased invasivity into blood vessels.
Conclusions
The results show that LNCaP‐19 mimics hormone refractory prostate cancer and therefore is an excellent tool for studies on androgen‐independent cancer and invasion. This study shows that transition into an androgen‐independent state correlates with several proinvasive alterations. Prostate 66: 1631–1640, 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pros.20469 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68898896</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68898896</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4329-cc44872cddfc22a5adcee5dc4554eb1252de80f7277b2dd1597c720d98763f173</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EokvhwgdAvsABkeJ_iZNjVWBBqugKCki9WF57sjVkk5BJuuy3Z7a7tDcky5ZHv_dGM4-x51KcSCHU237o8EQJU1QP2EyKymZCmPwhmwllRWaktkfsCeJPIQgX6jE7kkWlrBZ6xqYFiUc_Ag--DTBwMlsNgJi6lqd27LhvI5Vg94vQA11t2PKE3CN2IZE08k0ar7lvRhj8SEIklgdoGu7jNdxakQsVbzymmzRun7JHtW8Qnh3eY_btw_vLs4_Z-cX809npeRaMVlUWgjGlVSHGOijlcx8DQB6DyXMDS6lyFaEUtVXWLlWMMq9ssErEqrSFrqXVx-zN3hc30E9L1w9p7Yet63xyq6l3VFpNDsEZTQrCX-1xWsLvCXB064S7OXwL3YSuKMuKTkHg6z0YaHs4QH3nLIXbZeJ2mbjbTAh-cXCdlmuI9-ghBAJeHgCPwTf1QEkkvOdKRfMqQ5zcc5vUwPY_Ld3iy8XXf82zvSbhCH_uNH745Qqrbe5-fJ67Szm_-q7fLdyV_gtmzbcf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68898896</pqid></control><display><type>article</type><title>Prostate cancer progression into androgen independency is associated with alterations in cell adhesion and invasivity</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Jennbacken, Karin ; Gustavsson, Heléne ; Welén, Karin ; Vallbo, Christina ; Damber, Jan-Erik</creator><creatorcontrib>Jennbacken, Karin ; Gustavsson, Heléne ; Welén, Karin ; Vallbo, Christina ; Damber, Jan-Erik</creatorcontrib><description>Background
Mortality in prostate cancer is primarily due to failure to cure hormone refractory patients with metastatic disease. The present study focused on elucidating alterations in invasive properties, which are connected with progression into androgen independency.
Methods
Ability to grow without anchor, migration, cell adhesion properties and expression of invasive factors were investigated in LNCaP and its androgen‐independent subline LNCaP‐19. Also, invasive capacity into blood vessels was examined in subcutaneous tumors.
Results
Transition into an androgen‐independent state was associated with ability to grow without anchor, increased migration, and alterations in cell adhesion properties. The tumor suppressor E‐cadherin was downregulated and the proinvasive factors N‐cadherin, MMP‐9, and membrane type 1 (MT1)‐MMP were upregulated in LNCaP‐19. In addition, LNCaP‐19 displayed a markedly increased invasivity into blood vessels.
Conclusions
The results show that LNCaP‐19 mimics hormone refractory prostate cancer and therefore is an excellent tool for studies on androgen‐independent cancer and invasion. This study shows that transition into an androgen‐independent state correlates with several proinvasive alterations. Prostate 66: 1631–1640, 2006. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.20469</identifier><identifier>PMID: 16927303</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; androgen independent ; Androgens - metabolism ; Animals ; Biological and medical sciences ; cadherin ; Cell Adhesion - physiology ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - metabolism ; Cell Line, Tumor ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Neoplastic - pathology ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Gynecology. Andrology. Obstetrics ; hormone refractory ; Humans ; integrin ; LNCaP ; LNCaP • androgen independent • hormone refractory • cadherin • integrin • MMP ; Male ; Male genital diseases ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MMP ; Neoplasm Invasiveness - pathology ; Neoplasm Invasiveness - physiopathology ; Nephrology. Urinary tract diseases ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Urologi och njurmedicin ; Urology and Nephrology</subject><ispartof>Prostate, 2006-11, Vol.66 (15), p.1631-1640</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4329-cc44872cddfc22a5adcee5dc4554eb1252de80f7277b2dd1597c720d98763f173</citedby><cites>FETCH-LOGICAL-c4329-cc44872cddfc22a5adcee5dc4554eb1252de80f7277b2dd1597c720d98763f173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.20469$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.20469$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18255424$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16927303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/43763$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jennbacken, Karin</creatorcontrib><creatorcontrib>Gustavsson, Heléne</creatorcontrib><creatorcontrib>Welén, Karin</creatorcontrib><creatorcontrib>Vallbo, Christina</creatorcontrib><creatorcontrib>Damber, Jan-Erik</creatorcontrib><title>Prostate cancer progression into androgen independency is associated with alterations in cell adhesion and invasivity</title><title>Prostate</title><addtitle>Prostate</addtitle><description>Background
Mortality in prostate cancer is primarily due to failure to cure hormone refractory patients with metastatic disease. The present study focused on elucidating alterations in invasive properties, which are connected with progression into androgen independency.
Methods
Ability to grow without anchor, migration, cell adhesion properties and expression of invasive factors were investigated in LNCaP and its androgen‐independent subline LNCaP‐19. Also, invasive capacity into blood vessels was examined in subcutaneous tumors.
Results
Transition into an androgen‐independent state was associated with ability to grow without anchor, increased migration, and alterations in cell adhesion properties. The tumor suppressor E‐cadherin was downregulated and the proinvasive factors N‐cadherin, MMP‐9, and membrane type 1 (MT1)‐MMP were upregulated in LNCaP‐19. In addition, LNCaP‐19 displayed a markedly increased invasivity into blood vessels.
Conclusions
The results show that LNCaP‐19 mimics hormone refractory prostate cancer and therefore is an excellent tool for studies on androgen‐independent cancer and invasion. This study shows that transition into an androgen‐independent state correlates with several proinvasive alterations. Prostate 66: 1631–1640, 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>androgen independent</subject><subject>Androgens - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cadherin</subject><subject>Cell Adhesion - physiology</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Disease Progression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>hormone refractory</subject><subject>Humans</subject><subject>integrin</subject><subject>LNCaP</subject><subject>LNCaP • androgen independent • hormone refractory • cadherin • integrin • MMP</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>MMP</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Invasiveness - physiopathology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><subject>Urologi och njurmedicin</subject><subject>Urology and Nephrology</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EokvhwgdAvsABkeJ_iZNjVWBBqugKCki9WF57sjVkk5BJuuy3Z7a7tDcky5ZHv_dGM4-x51KcSCHU237o8EQJU1QP2EyKymZCmPwhmwllRWaktkfsCeJPIQgX6jE7kkWlrBZ6xqYFiUc_Ag--DTBwMlsNgJi6lqd27LhvI5Vg94vQA11t2PKE3CN2IZE08k0ar7lvRhj8SEIklgdoGu7jNdxakQsVbzymmzRun7JHtW8Qnh3eY_btw_vLs4_Z-cX809npeRaMVlUWgjGlVSHGOijlcx8DQB6DyXMDS6lyFaEUtVXWLlWMMq9ssErEqrSFrqXVx-zN3hc30E9L1w9p7Yet63xyq6l3VFpNDsEZTQrCX-1xWsLvCXB064S7OXwL3YSuKMuKTkHg6z0YaHs4QH3nLIXbZeJ2mbjbTAh-cXCdlmuI9-ghBAJeHgCPwTf1QEkkvOdKRfMqQ5zcc5vUwPY_Ld3iy8XXf82zvSbhCH_uNH745Qqrbe5-fJ67Szm_-q7fLdyV_gtmzbcf</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Jennbacken, Karin</creator><creator>Gustavsson, Heléne</creator><creator>Welén, Karin</creator><creator>Vallbo, Christina</creator><creator>Damber, Jan-Erik</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope></search><sort><creationdate>200611</creationdate><title>Prostate cancer progression into androgen independency is associated with alterations in cell adhesion and invasivity</title><author>Jennbacken, Karin ; Gustavsson, Heléne ; Welén, Karin ; Vallbo, Christina ; Damber, Jan-Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4329-cc44872cddfc22a5adcee5dc4554eb1252de80f7277b2dd1597c720d98763f173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>androgen independent</topic><topic>Androgens - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cadherin</topic><topic>Cell Adhesion - physiology</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Disease Progression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>hormone refractory</topic><topic>Humans</topic><topic>integrin</topic><topic>LNCaP</topic><topic>LNCaP • androgen independent • hormone refractory • cadherin • integrin • MMP</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>MMP</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Invasiveness - physiopathology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><topic>Urologi och njurmedicin</topic><topic>Urology and Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jennbacken, Karin</creatorcontrib><creatorcontrib>Gustavsson, Heléne</creatorcontrib><creatorcontrib>Welén, Karin</creatorcontrib><creatorcontrib>Vallbo, Christina</creatorcontrib><creatorcontrib>Damber, Jan-Erik</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jennbacken, Karin</au><au>Gustavsson, Heléne</au><au>Welén, Karin</au><au>Vallbo, Christina</au><au>Damber, Jan-Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostate cancer progression into androgen independency is associated with alterations in cell adhesion and invasivity</atitle><jtitle>Prostate</jtitle><addtitle>Prostate</addtitle><date>2006-11</date><risdate>2006</risdate><volume>66</volume><issue>15</issue><spage>1631</spage><epage>1640</epage><pages>1631-1640</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>Background
Mortality in prostate cancer is primarily due to failure to cure hormone refractory patients with metastatic disease. The present study focused on elucidating alterations in invasive properties, which are connected with progression into androgen independency.
Methods
Ability to grow without anchor, migration, cell adhesion properties and expression of invasive factors were investigated in LNCaP and its androgen‐independent subline LNCaP‐19. Also, invasive capacity into blood vessels was examined in subcutaneous tumors.
Results
Transition into an androgen‐independent state was associated with ability to grow without anchor, increased migration, and alterations in cell adhesion properties. The tumor suppressor E‐cadherin was downregulated and the proinvasive factors N‐cadherin, MMP‐9, and membrane type 1 (MT1)‐MMP were upregulated in LNCaP‐19. In addition, LNCaP‐19 displayed a markedly increased invasivity into blood vessels.
Conclusions
The results show that LNCaP‐19 mimics hormone refractory prostate cancer and therefore is an excellent tool for studies on androgen‐independent cancer and invasion. This study shows that transition into an androgen‐independent state correlates with several proinvasive alterations. Prostate 66: 1631–1640, 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16927303</pmid><doi>10.1002/pros.20469</doi><tpages>10</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology androgen independent Androgens - metabolism Animals Biological and medical sciences cadherin Cell Adhesion - physiology Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Line, Tumor Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Disease Progression Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics hormone refractory Humans integrin LNCaP LNCaP • androgen independent • hormone refractory • cadherin • integrin • MMP Male Male genital diseases Medical sciences Mice Mice, Inbred BALB C Mice, Nude MMP Neoplasm Invasiveness - pathology Neoplasm Invasiveness - physiopathology Nephrology. Urinary tract diseases Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Tumors Tumors of the urinary system Urinary tract. Prostate gland Urologi och njurmedicin Urology and Nephrology |
| title | Prostate cancer progression into androgen independency is associated with alterations in cell adhesion and invasivity |
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