Biochemical markers and genetic research of ADHD

Biochemical markers and genetic research of ADHD

ADHD (attention hyperactivity disorder) is a polygenetic disorder with various candidate genes. At this time, more than thirty dopaminergic, noradrenergic, serotonergic and GABA-ergic genes are known. The research of only some candidate genes (DRD4, DAT, DRD5, DBH, 5HTT, HTR1B and SNAP25) brought re...

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Veröffentlicht in:Neuro-endocrinology letters 2005-08, Vol.26 (4), p.423-430
Hauptverfasser: Paclt, I, Koudelová, J, Krepelová, A, Uhlíková, P, Gazdíková, M, Bauer, P
Format: Artikel
Sprache:eng
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Attention Deficit Disorder with Hyperactivity - genetics
Attention Deficit Disorder with Hyperactivity - physiopathology
Biomarkers
Brain Chemistry - genetics
Genetic Markers
Humans
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container_issue 4
container_start_page 423
container_title Neuro-endocrinology letters
container_volume 26
creator Paclt, I
Koudelová, J
Krepelová, A
Uhlíková, P
Gazdíková, M
Bauer, P
description ADHD (attention hyperactivity disorder) is a polygenetic disorder with various candidate genes. At this time, more than thirty dopaminergic, noradrenergic, serotonergic and GABA-ergic genes are known. The research of only some candidate genes (DRD4, DAT, DRD5, DBH, 5HTT, HTR1B and SNAP25) brought relatively consistent results confirming the heredity of ADHD syndromes. The results of research of other genes (DRD2, DRD3, MAO, ADR2A, GABA A3, GABA B3) are not clear yet. This paper summarizes the most important genetic data in correlations with biochemical periphery parameters (especially for DBH, HVA, MHPG, serotonin). Hypothetically, certain subgroups of ADHD may be identified by correlation of biochemical characteristics and some candidate genes. The paper discusses some implications for future research. Review.
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subjects Attention Deficit Disorder with Hyperactivity - genetics
Attention Deficit Disorder with Hyperactivity - physiopathology
Biomarkers
Brain Chemistry - genetics
Genetic Markers
Humans
title Biochemical markers and genetic research of ADHD
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