Correlation between urinary iodine levels and TSH of umbilical cord from newborns of the University Hospital at the School of Medicine from Ribeirão Preto, São Paulo
The safest and most efficient way to diagnose congenital hypothyroidism (CH) is through screening programs using serum thyroid stimulating hormone (TSH). CH occurs in one in 1:2,300-1:5,000 births but higher rates are found in iodine-deficient areas. Iodine was measured in the urine of 141 newborns...
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| Veröffentlicht in: | Arquivos brasileiros de endocrinologia e metabologia 2005-08, Vol.49 (4), p.516-520 |
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| container_title | Arquivos brasileiros de endocrinologia e metabologia |
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| creator | Alves, Maria Lúcia D'Arbo Maciel, Rui M de Barros Kunii, Ilda Iazigi, Nassim |
| description | The safest and most efficient way to diagnose congenital hypothyroidism (CH) is through screening programs using serum thyroid stimulating hormone (TSH). CH occurs in one in 1:2,300-1:5,000 births but higher rates are found in iodine-deficient areas. Iodine was measured in the urine of 141 newborns (87 males and 54 females) from Ribeirão Preto to complement the screening program developed by the School of Medicine of Ribeirão Preto (FMRP-USP) and Federal University of São Paulo (UNIFESP). TSH values did not disclose any case of CH, although we have seen an elevated ratio (0.96%) of calls for retests. The iodine urinary levels ranged from 2.1 to 194 microg/l (mean 58.3+/-36.2 microg/l). No differences between the levels of urinary iodine and gender or gestational ages were observed. A negative correlation between urinary iodine and TSH of blood from umbilical cord was found (r= -0.20, p= 0.02). |
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CH occurs in one in 1:2,300-1:5,000 births but higher rates are found in iodine-deficient areas. Iodine was measured in the urine of 141 newborns (87 males and 54 females) from Ribeirão Preto to complement the screening program developed by the School of Medicine of Ribeirão Preto (FMRP-USP) and Federal University of São Paulo (UNIFESP). TSH values did not disclose any case of CH, although we have seen an elevated ratio (0.96%) of calls for retests. The iodine urinary levels ranged from 2.1 to 194 microg/l (mean 58.3+/-36.2 microg/l). No differences between the levels of urinary iodine and gender or gestational ages were observed. A negative correlation between urinary iodine and TSH of blood from umbilical cord was found (r= -0.20, p= 0.02).</description><identifier>ISSN: 0004-2730</identifier><identifier>PMID: 16358079</identifier><language>por</language><publisher>Brazil</publisher><subject>Biomarkers - blood ; Biomarkers - urine ; Brazil ; Congenital Hypothyroidism - diagnosis ; Female ; Fetal Blood - chemistry ; Humans ; Infant, Newborn ; Iodine - urine ; Male ; Neonatal Screening ; Thyrotropin - blood</subject><ispartof>Arquivos brasileiros de endocrinologia e metabologia, 2005-08, Vol.49 (4), p.516-520</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16358079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alves, Maria Lúcia D'Arbo</creatorcontrib><creatorcontrib>Maciel, Rui M de Barros</creatorcontrib><creatorcontrib>Kunii, Ilda</creatorcontrib><creatorcontrib>Iazigi, Nassim</creatorcontrib><title>Correlation between urinary iodine levels and TSH of umbilical cord from newborns of the University Hospital at the School of Medicine from Ribeirão Preto, São Paulo</title><title>Arquivos brasileiros de endocrinologia e metabologia</title><addtitle>Arq Bras Endocrinol Metabol</addtitle><description>The safest and most efficient way to diagnose congenital hypothyroidism (CH) is through screening programs using serum thyroid stimulating hormone (TSH). 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A negative correlation between urinary iodine and TSH of blood from umbilical cord was found (r= -0.20, p= 0.02).</description><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Brazil</subject><subject>Congenital Hypothyroidism - diagnosis</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Iodine - urine</subject><subject>Male</subject><subject>Neonatal Screening</subject><subject>Thyrotropin - blood</subject><issn>0004-2730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMFKAzEYhPeg2Fp9BcnJkwvpJrvZHKWoFSqKreclyf6hkWyyJtkWn8eDD-KL2dZ6moH5mIE5ycYYY5oXjOBRdh7jO8YF5bw4y0bTipQ1Znycfc98CGBFMt4hCWkL4NAQjBPhExnfGgfIwgZsRMK1aLWcI6_R0EljjRIWKR9apIPvkIOt9MHFfZ7WgN6c2UCIJn2iuY-9STtapEO0VGvv7R58gtao_cah4tVIMOHny6OXAMnfoOXBi8H6i-xUCxvh8qiTbHV_t5rN88Xzw-PsdpH3JeW5JCUnpZYlVKzCDGpcAVMEy5bygrIKFCkLrJRmdCo0YXWthS6xVhgrLkRLJtn1X20f_McAMTWdiQqsFQ78EJuqrnlNMd2BV0dwkB20TR9Mt7us-X-W_AI2sXgW</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Alves, Maria Lúcia D'Arbo</creator><creator>Maciel, Rui M de Barros</creator><creator>Kunii, Ilda</creator><creator>Iazigi, Nassim</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>Correlation between urinary iodine levels and TSH of umbilical cord from newborns of the University Hospital at the School of Medicine from Ribeirão Preto, São Paulo</title><author>Alves, Maria Lúcia D'Arbo ; Maciel, Rui M de Barros ; Kunii, Ilda ; Iazigi, Nassim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p549-b35935fb5e67607e806e7c30bd492476ec3520ccf741af3788faf50fc00c9aad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>2005</creationdate><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Brazil</topic><topic>Congenital Hypothyroidism - diagnosis</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Iodine - urine</topic><topic>Male</topic><topic>Neonatal Screening</topic><topic>Thyrotropin - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Alves, Maria Lúcia D'Arbo</creatorcontrib><creatorcontrib>Maciel, Rui M de Barros</creatorcontrib><creatorcontrib>Kunii, Ilda</creatorcontrib><creatorcontrib>Iazigi, Nassim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alves, Maria Lúcia D'Arbo</au><au>Maciel, Rui M de Barros</au><au>Kunii, Ilda</au><au>Iazigi, Nassim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between urinary iodine levels and TSH of umbilical cord from newborns of the University Hospital at the School of Medicine from Ribeirão Preto, São Paulo</atitle><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle><addtitle>Arq Bras Endocrinol Metabol</addtitle><date>2005-08</date><risdate>2005</risdate><volume>49</volume><issue>4</issue><spage>516</spage><epage>520</epage><pages>516-520</pages><issn>0004-2730</issn><abstract>The safest and most efficient way to diagnose congenital hypothyroidism (CH) is through screening programs using serum thyroid stimulating hormone (TSH). 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| subjects | Biomarkers - blood Biomarkers - urine Brazil Congenital Hypothyroidism - diagnosis Female Fetal Blood - chemistry Humans Infant, Newborn Iodine - urine Male Neonatal Screening Thyrotropin - blood |
| title | Correlation between urinary iodine levels and TSH of umbilical cord from newborns of the University Hospital at the School of Medicine from Ribeirão Preto, São Paulo |
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