Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton

Platelet activation by potent, Ca 2+-mobilizing agonists results in shedding of microparticles that are active in coagulation. Here we show that platelets under storage produce procoagulant microparticles in the absence of agonist. Microparticle formation by resting platelets results from αIIbβ3 sig...

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Veröffentlicht in:	FEBS letters 2006-10, Vol.580 (22), p.5313-5320
Hauptverfasser:	Cauwenberghs, Sandra, Feijge, Marion A.H., Harper, Alan G.S., Sage, Stewart O., Curvers, Joyce, Heemskerk, Johan W.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin cytoskeleton Actin Cytoskeleton - metabolism Blood Coagulation - drug effects Blood Component Transfusion - adverse effects Blood Platelets - cytology Blood Platelets - metabolism Calcium Channel Blockers - pharmacology Calpain Calpain - metabolism Coagulants - metabolism Enzyme Activation - drug effects FITC Fluorescein isothiocyanate Humans Integrin beta3 - metabolism Integrin αIIbβ3 mAb Microparticles monoclonal antibody PFP phosphatidylserine Platelet Activation - drug effects Platelet Membrane Glycoprotein IIb - metabolism platelet-free plasma platelet-rich plasma Preservation, Biological Procoagulant activity PRP Signal Transduction Thrombocytopenia - metabolism Thrombocytopenia - therapy
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