Total Synthesis of (−)-Himgaline

The first total synthesis of (−)-himgaline and a highly enantioselective synthesis of its congener (−)-GB 13 are described. Decarboxylative aza-Michael reaction of the hexacyclic lactone precursor under acidic conditions, followed by basic workup, yielded (−)-GB 13 in 80% yield. Cyclization of (−)-G...

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Veröffentlicht in:	Journal of the American Chemical Society 2006-10, Vol.128 (39), p.12654-12655
Hauptverfasser:	Shah, Unmesh, Chackalamannil, Samuel, Ganguly, Ashit K, Chelliah, Mariappan, Kolotuchin, Sergei, Buevich, Alexei, McPhail, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged Bicyclo Compounds - chemical synthesis Chemistry Crystallography, X-Ray Exact sciences and technology General and physical chemistry Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Plant Bark - chemistry Trees - chemistry
Online-Zugang:	Volltext
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