Parkinson's disease and family history
The study of family history in Parkinson's disease (PD) has resulted in considerable debate over the role of genetic factors in the development of PD. Despite this, family history is consistently identified as an independent risk factor for PD. A multifactorial disease process in which genetic,...
Gespeichert in:
| Veröffentlicht in: | Parkinsonism & related disorders 2006-10, Vol.12 (7), p.399-409 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 409 |
|---|---|
| container_issue | 7 |
| container_start_page | 399 |
| container_title | Parkinsonism & related disorders |
| container_volume | 12 |
| creator | Sellbach, Annabella N. Boyle, Richard S. Silburn, Peter A. Mellick, George D. |
| description | The study of family history in Parkinson's disease (PD) has resulted in considerable debate over the role of genetic factors in the development of PD. Despite this, family history is consistently identified as an independent risk factor for PD. A multifactorial disease process in which genetic, environmental and lifestyle factors culminate in overall risk seems most likely. This article reviews existing studies of familial aggregation in PD. Recent insights into rare genetic causes of PD have affirmed the importance of ongoing family history research. Future efforts should emphasise well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up. |
| doi_str_mv | 10.1016/j.parkreldis.2006.03.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68896355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1353802006000708</els_id><sourcerecordid>68896355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-2dde47bdaf06066b27999f60b75980f44905e06240316f0d913dd07f8ee22ede3</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EolD4BZRVWSWM7dhOllDxkirBAtaWE4-FSx7FbpH697hqpS5ZzSzOvaM5hGQUCgpU3i2LlQnfATvrY8EAZAG8AGAn5IJWiueCMnmadi54XgGDCbmMcQkASgA_JxMqVa0YFRdk9p6K_BDH4TZmqQ1NxMwMNnOm9902-_JxPYbtFTlzpot4fZhT8vn0-DF_yRdvz6_z-0XecsXWObMWS9VY40CClA1TdV07CY0SdQWuLGsQCJKVwKl0YGvKrQXlKkTG0CKfktm-dxXGnw3Gte59bLHrzIDjJmpZVbXkQiSw2oNtGGMM6PQq-N6Eraagd470Uh8d6Z0jDVwnRyl6c7ixaXq0x-BBSgIe9gCmT389Bh1bj0OL1gds19qO_v8rf0rye98</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68896355</pqid></control><display><type>article</type><title>Parkinson's disease and family history</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Sellbach, Annabella N. ; Boyle, Richard S. ; Silburn, Peter A. ; Mellick, George D.</creator><creatorcontrib>Sellbach, Annabella N. ; Boyle, Richard S. ; Silburn, Peter A. ; Mellick, George D.</creatorcontrib><description>The study of family history in Parkinson's disease (PD) has resulted in considerable debate over the role of genetic factors in the development of PD. Despite this, family history is consistently identified as an independent risk factor for PD. A multifactorial disease process in which genetic, environmental and lifestyle factors culminate in overall risk seems most likely. This article reviews existing studies of familial aggregation in PD. Recent insights into rare genetic causes of PD have affirmed the importance of ongoing family history research. Future efforts should emphasise well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2006.03.002</identifier><identifier>PMID: 16797215</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Epidemiology ; Familial aggregation ; Family Health ; Family history ; Genetic Predisposition to Disease - epidemiology ; Genetics ; Humans ; Parkinson Disease - epidemiology ; Parkinson Disease - genetics ; Parkinson's disease ; Parkinsonism ; Risk Factors</subject><ispartof>Parkinsonism & related disorders, 2006-10, Vol.12 (7), p.399-409</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-2dde47bdaf06066b27999f60b75980f44905e06240316f0d913dd07f8ee22ede3</citedby><cites>FETCH-LOGICAL-c372t-2dde47bdaf06066b27999f60b75980f44905e06240316f0d913dd07f8ee22ede3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.parkreldis.2006.03.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16797215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sellbach, Annabella N.</creatorcontrib><creatorcontrib>Boyle, Richard S.</creatorcontrib><creatorcontrib>Silburn, Peter A.</creatorcontrib><creatorcontrib>Mellick, George D.</creatorcontrib><title>Parkinson's disease and family history</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>The study of family history in Parkinson's disease (PD) has resulted in considerable debate over the role of genetic factors in the development of PD. Despite this, family history is consistently identified as an independent risk factor for PD. A multifactorial disease process in which genetic, environmental and lifestyle factors culminate in overall risk seems most likely. This article reviews existing studies of familial aggregation in PD. Recent insights into rare genetic causes of PD have affirmed the importance of ongoing family history research. Future efforts should emphasise well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up.</description><subject>Epidemiology</subject><subject>Familial aggregation</subject><subject>Family Health</subject><subject>Family history</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetics</subject><subject>Humans</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>Parkinsonism</subject><subject>Risk Factors</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EolD4BZRVWSWM7dhOllDxkirBAtaWE4-FSx7FbpH697hqpS5ZzSzOvaM5hGQUCgpU3i2LlQnfATvrY8EAZAG8AGAn5IJWiueCMnmadi54XgGDCbmMcQkASgA_JxMqVa0YFRdk9p6K_BDH4TZmqQ1NxMwMNnOm9902-_JxPYbtFTlzpot4fZhT8vn0-DF_yRdvz6_z-0XecsXWObMWS9VY40CClA1TdV07CY0SdQWuLGsQCJKVwKl0YGvKrQXlKkTG0CKfktm-dxXGnw3Gte59bLHrzIDjJmpZVbXkQiSw2oNtGGMM6PQq-N6Eraagd470Uh8d6Z0jDVwnRyl6c7ixaXq0x-BBSgIe9gCmT389Bh1bj0OL1gds19qO_v8rf0rye98</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Sellbach, Annabella N.</creator><creator>Boyle, Richard S.</creator><creator>Silburn, Peter A.</creator><creator>Mellick, George D.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200610</creationdate><title>Parkinson's disease and family history</title><author>Sellbach, Annabella N. ; Boyle, Richard S. ; Silburn, Peter A. ; Mellick, George D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-2dde47bdaf06066b27999f60b75980f44905e06240316f0d913dd07f8ee22ede3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Epidemiology</topic><topic>Familial aggregation</topic><topic>Family Health</topic><topic>Family history</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetics</topic><topic>Humans</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson's disease</topic><topic>Parkinsonism</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sellbach, Annabella N.</creatorcontrib><creatorcontrib>Boyle, Richard S.</creatorcontrib><creatorcontrib>Silburn, Peter A.</creatorcontrib><creatorcontrib>Mellick, George D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sellbach, Annabella N.</au><au>Boyle, Richard S.</au><au>Silburn, Peter A.</au><au>Mellick, George D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parkinson's disease and family history</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2006-10</date><risdate>2006</risdate><volume>12</volume><issue>7</issue><spage>399</spage><epage>409</epage><pages>399-409</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>The study of family history in Parkinson's disease (PD) has resulted in considerable debate over the role of genetic factors in the development of PD. Despite this, family history is consistently identified as an independent risk factor for PD. A multifactorial disease process in which genetic, environmental and lifestyle factors culminate in overall risk seems most likely. This article reviews existing studies of familial aggregation in PD. Recent insights into rare genetic causes of PD have affirmed the importance of ongoing family history research. Future efforts should emphasise well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16797215</pmid><doi>10.1016/j.parkreldis.2006.03.002</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1353-8020 |
| ispartof | Parkinsonism & related disorders, 2006-10, Vol.12 (7), p.399-409 |
| issn | 1353-8020 1873-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68896355 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Epidemiology Familial aggregation Family Health Family history Genetic Predisposition to Disease - epidemiology Genetics Humans Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Parkinsonism Risk Factors |
| title | Parkinson's disease and family history |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T19%3A09%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parkinson's%20disease%20and%20family%20history&rft.jtitle=Parkinsonism%20&%20related%20disorders&rft.au=Sellbach,%20Annabella%20N.&rft.date=2006-10&rft.volume=12&rft.issue=7&rft.spage=399&rft.epage=409&rft.pages=399-409&rft.issn=1353-8020&rft.eissn=1873-5126&rft_id=info:doi/10.1016/j.parkreldis.2006.03.002&rft_dat=%3Cproquest_cross%3E68896355%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68896355&rft_id=info:pmid/16797215&rft_els_id=S1353802006000708&rfr_iscdi=true |