Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts

Sulfasalazine is characterised by low oral bioavailability. In this study, its intestinal transport characteristics were studied in an in‐vitro, ex‐vivo and in‐situ system. The absorptive transport of sulfasalazine across Caco‐2 monolayers appeared to be lower than the secretory transport (Papp‐abs...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2005-12, Vol.57 (12), p.1565-1573
Hauptverfasser:	Mols, Raf, Deferme, Sven, Augustijns, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Availability Caco-2 Cells Chromatography, High Pressure Liquid Fruit - chemistry Humans Intestinal Absorption Models, Biological Multidrug Resistance-Associated Proteins - antagonists & inhibitors Plant Extracts - administration & dosage Rats Sulfasalazine - blood Sulfasalazine - pharmacokinetics
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