Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation

The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we prev...

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Veröffentlicht in:	Molecular and cellular neuroscience 2006-10, Vol.33 (2), p.160-169
Hauptverfasser:	Baudouin, Stéphane J., Pujol, Fabien, Nicot, Arnaud, Kitabgi, Patrick, Boudin, Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrestins - metabolism Axons - metabolism beta-Arrestins Cell Compartmentation - physiology Cells, Cultured Chemokine Chemokine CXCL12 Chemokines, CXC - pharmacology Dendrites - metabolism Development Endocytosis Endocytosis - physiology Endosomes - metabolism G-protein-coupled receptor Green Fluorescent Proteins - genetics Hippocampal neuron Hippocampus - cytology Male Protein Transport - physiology Rats Rats, Sprague-Dawley Receptors, CXCR4 - agonists Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Signal Transduction - physiology Trafficking
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