Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation
The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we prev...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular neuroscience 2006-10, Vol.33 (2), p.160-169 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 169 |
|---|---|
| container_issue | 2 |
| container_start_page | 160 |
| container_title | Molecular and cellular neuroscience |
| container_volume | 33 |
| creator | Baudouin, Stéphane J. Pujol, Fabien Nicot, Arnaud Kitabgi, Patrick Boudin, Hélène |
| description | The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains. |
| doi_str_mv | 10.1016/j.mcn.2006.07.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68895027</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1044743106001606</els_id><sourcerecordid>68895027</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-5b3b1531727e621b0df99e02a47a4b7dc3e0eb10298effe6d9468e07a20879ae3</originalsourceid><addsrcrecordid>eNqFkM1q3DAURkVpadIkD5BN8Ko7u1c_tiyyKtOkCQQKpYHuhCxfJ5rY1kSSU_L2lZmB7NqVLuicb3EIOadQUaDNl2012bliAE0FsgKQ78gxBVWXijP5fr2FKKXg9Ih8inELADVT_CM5oo2qmWjEMdHfcO6DS1hGHNEm94JFwN7FFFy3JOfnwg9FesTCPuLkn9y8_lvcJR-Kze_NT1EMfhz9Hzc_FObBz9ksYnLTMprVPiUfBjNGPDu8J-T--urX5qa8-_H9dvP1rrS8ZamsO97RmlPJJDaMdtAPSiEwI6QRnewtR8COAlMtDgM2vRJNiyANg1Yqg_yEfN7v7oJ_XjAmPblocRzNjH6JumlbVQOT_wWp4m0tWZtBugdt8DEGHPQuuMmEV01Br_n1Vuf8es2vQeqcPzsXh_Glm7B_Mw69M3C5BzC3eHEYdLQOZ5uL56pJ9979Y_4vaK-Wyg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19385728</pqid></control><display><type>article</type><title>Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Baudouin, Stéphane J. ; Pujol, Fabien ; Nicot, Arnaud ; Kitabgi, Patrick ; Boudin, Hélène</creator><creatorcontrib>Baudouin, Stéphane J. ; Pujol, Fabien ; Nicot, Arnaud ; Kitabgi, Patrick ; Boudin, Hélène</creatorcontrib><description>The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.</description><identifier>ISSN: 1044-7431</identifier><identifier>EISSN: 1095-9327</identifier><identifier>DOI: 10.1016/j.mcn.2006.07.007</identifier><identifier>PMID: 16952464</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Arrestins - metabolism ; Axons - metabolism ; beta-Arrestins ; Cell Compartmentation - physiology ; Cells, Cultured ; Chemokine ; Chemokine CXCL12 ; Chemokines, CXC - pharmacology ; Dendrites - metabolism ; Development ; Endocytosis ; Endocytosis - physiology ; Endosomes - metabolism ; G-protein-coupled receptor ; Green Fluorescent Proteins - genetics ; Hippocampal neuron ; Hippocampus - cytology ; Male ; Protein Transport - physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, CXCR4 - agonists ; Receptors, CXCR4 - genetics ; Receptors, CXCR4 - metabolism ; Signal Transduction - physiology ; Trafficking</subject><ispartof>Molecular and cellular neuroscience, 2006-10, Vol.33 (2), p.160-169</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-5b3b1531727e621b0df99e02a47a4b7dc3e0eb10298effe6d9468e07a20879ae3</citedby><cites>FETCH-LOGICAL-c382t-5b3b1531727e621b0df99e02a47a4b7dc3e0eb10298effe6d9468e07a20879ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mcn.2006.07.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16952464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baudouin, Stéphane J.</creatorcontrib><creatorcontrib>Pujol, Fabien</creatorcontrib><creatorcontrib>Nicot, Arnaud</creatorcontrib><creatorcontrib>Kitabgi, Patrick</creatorcontrib><creatorcontrib>Boudin, Hélène</creatorcontrib><title>Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation</title><title>Molecular and cellular neuroscience</title><addtitle>Mol Cell Neurosci</addtitle><description>The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.</description><subject>Animals</subject><subject>Arrestins - metabolism</subject><subject>Axons - metabolism</subject><subject>beta-Arrestins</subject><subject>Cell Compartmentation - physiology</subject><subject>Cells, Cultured</subject><subject>Chemokine</subject><subject>Chemokine CXCL12</subject><subject>Chemokines, CXC - pharmacology</subject><subject>Dendrites - metabolism</subject><subject>Development</subject><subject>Endocytosis</subject><subject>Endocytosis - physiology</subject><subject>Endosomes - metabolism</subject><subject>G-protein-coupled receptor</subject><subject>Green Fluorescent Proteins - genetics</subject><subject>Hippocampal neuron</subject><subject>Hippocampus - cytology</subject><subject>Male</subject><subject>Protein Transport - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, CXCR4 - agonists</subject><subject>Receptors, CXCR4 - genetics</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Trafficking</subject><issn>1044-7431</issn><issn>1095-9327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1q3DAURkVpadIkD5BN8Ko7u1c_tiyyKtOkCQQKpYHuhCxfJ5rY1kSSU_L2lZmB7NqVLuicb3EIOadQUaDNl2012bliAE0FsgKQ78gxBVWXijP5fr2FKKXg9Ih8inELADVT_CM5oo2qmWjEMdHfcO6DS1hGHNEm94JFwN7FFFy3JOfnwg9FesTCPuLkn9y8_lvcJR-Kze_NT1EMfhz9Hzc_FObBz9ksYnLTMprVPiUfBjNGPDu8J-T--urX5qa8-_H9dvP1rrS8ZamsO97RmlPJJDaMdtAPSiEwI6QRnewtR8COAlMtDgM2vRJNiyANg1Yqg_yEfN7v7oJ_XjAmPblocRzNjH6JumlbVQOT_wWp4m0tWZtBugdt8DEGHPQuuMmEV01Br_n1Vuf8es2vQeqcPzsXh_Glm7B_Mw69M3C5BzC3eHEYdLQOZ5uL56pJ9979Y_4vaK-Wyg</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Baudouin, Stéphane J.</creator><creator>Pujol, Fabien</creator><creator>Nicot, Arnaud</creator><creator>Kitabgi, Patrick</creator><creator>Boudin, Hélène</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation</title><author>Baudouin, Stéphane J. ; Pujol, Fabien ; Nicot, Arnaud ; Kitabgi, Patrick ; Boudin, Hélène</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-5b3b1531727e621b0df99e02a47a4b7dc3e0eb10298effe6d9468e07a20879ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Arrestins - metabolism</topic><topic>Axons - metabolism</topic><topic>beta-Arrestins</topic><topic>Cell Compartmentation - physiology</topic><topic>Cells, Cultured</topic><topic>Chemokine</topic><topic>Chemokine CXCL12</topic><topic>Chemokines, CXC - pharmacology</topic><topic>Dendrites - metabolism</topic><topic>Development</topic><topic>Endocytosis</topic><topic>Endocytosis - physiology</topic><topic>Endosomes - metabolism</topic><topic>G-protein-coupled receptor</topic><topic>Green Fluorescent Proteins - genetics</topic><topic>Hippocampal neuron</topic><topic>Hippocampus - cytology</topic><topic>Male</topic><topic>Protein Transport - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, CXCR4 - agonists</topic><topic>Receptors, CXCR4 - genetics</topic><topic>Receptors, CXCR4 - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Trafficking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baudouin, Stéphane J.</creatorcontrib><creatorcontrib>Pujol, Fabien</creatorcontrib><creatorcontrib>Nicot, Arnaud</creatorcontrib><creatorcontrib>Kitabgi, Patrick</creatorcontrib><creatorcontrib>Boudin, Hélène</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baudouin, Stéphane J.</au><au>Pujol, Fabien</au><au>Nicot, Arnaud</au><au>Kitabgi, Patrick</au><au>Boudin, Hélène</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation</atitle><jtitle>Molecular and cellular neuroscience</jtitle><addtitle>Mol Cell Neurosci</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>33</volume><issue>2</issue><spage>160</spage><epage>169</epage><pages>160-169</pages><issn>1044-7431</issn><eissn>1095-9327</eissn><abstract>The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16952464</pmid><doi>10.1016/j.mcn.2006.07.007</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1044-7431 |
| ispartof | Molecular and cellular neuroscience, 2006-10, Vol.33 (2), p.160-169 |
| issn | 1044-7431 1095-9327 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68895027 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arrestins - metabolism Axons - metabolism beta-Arrestins Cell Compartmentation - physiology Cells, Cultured Chemokine Chemokine CXCL12 Chemokines, CXC - pharmacology Dendrites - metabolism Development Endocytosis Endocytosis - physiology Endosomes - metabolism G-protein-coupled receptor Green Fluorescent Proteins - genetics Hippocampal neuron Hippocampus - cytology Male Protein Transport - physiology Rats Rats, Sprague-Dawley Receptors, CXCR4 - agonists Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Signal Transduction - physiology Trafficking |
| title | Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A22%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dendrite-selective%20redistribution%20of%20the%20chemokine%20receptor%20CXCR4%20following%20agonist%20stimulation&rft.jtitle=Molecular%20and%20cellular%20neuroscience&rft.au=Baudouin,%20St%C3%A9phane%20J.&rft.date=2006-10-01&rft.volume=33&rft.issue=2&rft.spage=160&rft.epage=169&rft.pages=160-169&rft.issn=1044-7431&rft.eissn=1095-9327&rft_id=info:doi/10.1016/j.mcn.2006.07.007&rft_dat=%3Cproquest_cross%3E68895027%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19385728&rft_id=info:pmid/16952464&rft_els_id=S1044743106001606&rfr_iscdi=true |