Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts

Licochalcone A, a novel flavonoid isolated from the root of Glycyrrhiza inflata, has been reported to exhibit anti-inflammatory activity in animal models. In this study, we examined the effect of licochalcone A on the production of chemical mediators such as prostaglandin (PG)E2 and cytokines by int...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2005-12, Vol.57 (12), p.1661-1666
Hauptverfasser:	Furuhashi, Ikue, Iwata, Susumu, Shibata, Shoji, Sato, Toshitsugu, Inoue, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Chalcone - analogs & derivatives Chalcone - pharmacology Chalcones Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Dinoprostone - biosynthesis DNA Primers Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - metabolism Glycyrrhiza - chemistry Humans In Vitro Techniques Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Plant Roots - chemistry Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Skin - cytology Skin - drug effects Skin - enzymology Skin - metabolism
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