Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis
Objective To describe patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease‐related variables as potential predictors of adherence. Methods Adherence to NSAIDs was monitored i...
Gespeichert in:
| Veröffentlicht in: | Arthritis and rheumatism 2005-12, Vol.53 (6), p.905-910 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 910 |
|---|---|
| container_issue | 6 |
| container_start_page | 905 |
| container_title | Arthritis and rheumatism |
| container_volume | 53 |
| creator | Rapoff, Michael A. Belmont, John M. Lindsley, Carol B. Olson, Nancy Y. |
| description | Objective
To describe patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease‐related variables as potential predictors of adherence.
Methods
Adherence to NSAIDs was monitored in 48 children with JRA (mean age 8.6 years) over 28 consecutive days using an electronic monitoring device. Measures of disease activity (active joint counts, morning stiffness) and demographics (age, sex, ethnicity, socioeconomic status) were also obtained.
Results
Using an 80% adherence cut point, 25 (52%) patients were classified as adherent and 23 (48%) as nonadherent. There was considerable variability across patients, with full adherence (taking all doses on time) ranging from 0 to 100% of the monitored days. Logistic regression showed that active joint count and socioeconomic status were the only significant predictors. Both were positively related to adherence. The model correctly classified 70.5% of patients as either adherent or nonadherent (Cox and Snell R2 = 0.295, P = 0.0005).
Conclusion
Children newly diagnosed with JRA are more likely to adhere to an NSAID regimen if they have a greater number of active joints or their families have higher socioeconomic status. The former finding suggests that children's adherence is symptom‐driven, while the latter suggests that families of lower socioeconomic status deserve special attention to address adherence issues. |
| doi_str_mv | 10.1002/art.21603 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68892885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68892885</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3533-b16d63ef4869bd4387763e431670f8eb9e58dfc85c6130f95de3c4709c6cdcf73</originalsourceid><addsrcrecordid>eNp10MFq3DAQBmARGpJtmkNfoOjSQA9OJMuW5WMImzawEAjJ2cjSuKvFlraS3GXfvtPswp5ykob5mBl-Qr5ydssZK-90zLcll0yckQWvy7ZgXPBPZMEYqwpRt_ySfE5pg2UpanFBLrkUVclZtSDb5Qgmx-Cd0eO4pxP-cohgqbZriOAN0BzoBBZBdsEn2u-phx1a6_RvHxLaLbbA50R3Lq_pZv4L3o1A4xrmSefgcFrM6-iyS1_I-aDHBNfH94q8PS5fH34Vq-efTw_3q8LgiaLoubRSwFAp2fa2EqppsKwElw0bFPQt1MoORtVGcsGGtrYgTNWw1khjzdCIK3JzmLuN4c8MKXeTSwbGUXsIc-qkUm2pVI3wxwGaGFKKMHTb6CYd9x1n3f94O7y9e48X7bfj0LnHSE7ymCeC70egEwY6RO2NSyfXSNY0SqK7O7gd5rT_eGN3__J6WP0PfouTzA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68892885</pqid></control><display><type>article</type><title>Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Rapoff, Michael A. ; Belmont, John M. ; Lindsley, Carol B. ; Olson, Nancy Y.</creator><creatorcontrib>Rapoff, Michael A. ; Belmont, John M. ; Lindsley, Carol B. ; Olson, Nancy Y.</creatorcontrib><description>Objective
To describe patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease‐related variables as potential predictors of adherence.
Methods
Adherence to NSAIDs was monitored in 48 children with JRA (mean age 8.6 years) over 28 consecutive days using an electronic monitoring device. Measures of disease activity (active joint counts, morning stiffness) and demographics (age, sex, ethnicity, socioeconomic status) were also obtained.
Results
Using an 80% adherence cut point, 25 (52%) patients were classified as adherent and 23 (48%) as nonadherent. There was considerable variability across patients, with full adherence (taking all doses on time) ranging from 0 to 100% of the monitored days. Logistic regression showed that active joint count and socioeconomic status were the only significant predictors. Both were positively related to adherence. The model correctly classified 70.5% of patients as either adherent or nonadherent (Cox and Snell R2 = 0.295, P = 0.0005).
Conclusion
Children newly diagnosed with JRA are more likely to adhere to an NSAID regimen if they have a greater number of active joints or their families have higher socioeconomic status. The former finding suggests that children's adherence is symptom‐driven, while the latter suggests that families of lower socioeconomic status deserve special attention to address adherence issues.</description><identifier>ISSN: 0004-3591</identifier><identifier>ISSN: 0893-7524</identifier><identifier>EISSN: 1529-0131</identifier><identifier>EISSN: 1529-0123</identifier><identifier>DOI: 10.1002/art.21603</identifier><identifier>PMID: 16342104</identifier><identifier>CODEN: ARCREG</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adherence ; Adolescent ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antirheumatic Agents - therapeutic use ; Arthritis, Juvenile - diagnosis ; Arthritis, Juvenile - drug therapy ; Arthritis, Juvenile - physiopathology ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Child ; Child, Preschool ; Diseases of the osteoarticular system ; Drug Monitoring - methods ; Electronic monitoring ; Electronics ; Female ; Health Status ; Humans ; Inflammatory joint diseases ; Juvenile rheumatoid arthritis ; Male ; Medical sciences ; Nonsteroidal antiinflammatory drugs ; Patient Compliance ; Pharmacology. Drug treatments ; Severity of Illness Index ; Social Class</subject><ispartof>Arthritis and rheumatism, 2005-12, Vol.53 (6), p.905-910</ispartof><rights>Copyright © 2005 by the American College of Rheumatology</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-b16d63ef4869bd4387763e431670f8eb9e58dfc85c6130f95de3c4709c6cdcf73</citedby><cites>FETCH-LOGICAL-c3533-b16d63ef4869bd4387763e431670f8eb9e58dfc85c6130f95de3c4709c6cdcf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.21603$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.21603$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17607786$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16342104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rapoff, Michael A.</creatorcontrib><creatorcontrib>Belmont, John M.</creatorcontrib><creatorcontrib>Lindsley, Carol B.</creatorcontrib><creatorcontrib>Olson, Nancy Y.</creatorcontrib><title>Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective
To describe patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease‐related variables as potential predictors of adherence.
Methods
Adherence to NSAIDs was monitored in 48 children with JRA (mean age 8.6 years) over 28 consecutive days using an electronic monitoring device. Measures of disease activity (active joint counts, morning stiffness) and demographics (age, sex, ethnicity, socioeconomic status) were also obtained.
Results
Using an 80% adherence cut point, 25 (52%) patients were classified as adherent and 23 (48%) as nonadherent. There was considerable variability across patients, with full adherence (taking all doses on time) ranging from 0 to 100% of the monitored days. Logistic regression showed that active joint count and socioeconomic status were the only significant predictors. Both were positively related to adherence. The model correctly classified 70.5% of patients as either adherent or nonadherent (Cox and Snell R2 = 0.295, P = 0.0005).
Conclusion
Children newly diagnosed with JRA are more likely to adhere to an NSAID regimen if they have a greater number of active joints or their families have higher socioeconomic status. The former finding suggests that children's adherence is symptom‐driven, while the latter suggests that families of lower socioeconomic status deserve special attention to address adherence issues.</description><subject>Adherence</subject><subject>Adolescent</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Juvenile - diagnosis</subject><subject>Arthritis, Juvenile - drug therapy</subject><subject>Arthritis, Juvenile - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases of the osteoarticular system</subject><subject>Drug Monitoring - methods</subject><subject>Electronic monitoring</subject><subject>Electronics</subject><subject>Female</subject><subject>Health Status</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Juvenile rheumatoid arthritis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nonsteroidal antiinflammatory drugs</subject><subject>Patient Compliance</subject><subject>Pharmacology. Drug treatments</subject><subject>Severity of Illness Index</subject><subject>Social Class</subject><issn>0004-3591</issn><issn>0893-7524</issn><issn>1529-0131</issn><issn>1529-0123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFq3DAQBmARGpJtmkNfoOjSQA9OJMuW5WMImzawEAjJ2cjSuKvFlraS3GXfvtPswp5ykob5mBl-Qr5ydssZK-90zLcll0yckQWvy7ZgXPBPZMEYqwpRt_ySfE5pg2UpanFBLrkUVclZtSDb5Qgmx-Cd0eO4pxP-cohgqbZriOAN0BzoBBZBdsEn2u-phx1a6_RvHxLaLbbA50R3Lq_pZv4L3o1A4xrmSefgcFrM6-iyS1_I-aDHBNfH94q8PS5fH34Vq-efTw_3q8LgiaLoubRSwFAp2fa2EqppsKwElw0bFPQt1MoORtVGcsGGtrYgTNWw1khjzdCIK3JzmLuN4c8MKXeTSwbGUXsIc-qkUm2pVI3wxwGaGFKKMHTb6CYd9x1n3f94O7y9e48X7bfj0LnHSE7ymCeC70egEwY6RO2NSyfXSNY0SqK7O7gd5rT_eGN3__J6WP0PfouTzA</recordid><startdate>20051215</startdate><enddate>20051215</enddate><creator>Rapoff, Michael A.</creator><creator>Belmont, John M.</creator><creator>Lindsley, Carol B.</creator><creator>Olson, Nancy Y.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051215</creationdate><title>Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis</title><author>Rapoff, Michael A. ; Belmont, John M. ; Lindsley, Carol B. ; Olson, Nancy Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-b16d63ef4869bd4387763e431670f8eb9e58dfc85c6130f95de3c4709c6cdcf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adherence</topic><topic>Adolescent</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Juvenile - diagnosis</topic><topic>Arthritis, Juvenile - drug therapy</topic><topic>Arthritis, Juvenile - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases of the osteoarticular system</topic><topic>Drug Monitoring - methods</topic><topic>Electronic monitoring</topic><topic>Electronics</topic><topic>Female</topic><topic>Health Status</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Juvenile rheumatoid arthritis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nonsteroidal antiinflammatory drugs</topic><topic>Patient Compliance</topic><topic>Pharmacology. Drug treatments</topic><topic>Severity of Illness Index</topic><topic>Social Class</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rapoff, Michael A.</creatorcontrib><creatorcontrib>Belmont, John M.</creatorcontrib><creatorcontrib>Lindsley, Carol B.</creatorcontrib><creatorcontrib>Olson, Nancy Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rapoff, Michael A.</au><au>Belmont, John M.</au><au>Lindsley, Carol B.</au><au>Olson, Nancy Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>2005-12-15</date><risdate>2005</risdate><volume>53</volume><issue>6</issue><spage>905</spage><epage>910</epage><pages>905-910</pages><issn>0004-3591</issn><issn>0893-7524</issn><eissn>1529-0131</eissn><eissn>1529-0123</eissn><coden>ARCREG</coden><abstract>Objective
To describe patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease‐related variables as potential predictors of adherence.
Methods
Adherence to NSAIDs was monitored in 48 children with JRA (mean age 8.6 years) over 28 consecutive days using an electronic monitoring device. Measures of disease activity (active joint counts, morning stiffness) and demographics (age, sex, ethnicity, socioeconomic status) were also obtained.
Results
Using an 80% adherence cut point, 25 (52%) patients were classified as adherent and 23 (48%) as nonadherent. There was considerable variability across patients, with full adherence (taking all doses on time) ranging from 0 to 100% of the monitored days. Logistic regression showed that active joint count and socioeconomic status were the only significant predictors. Both were positively related to adherence. The model correctly classified 70.5% of patients as either adherent or nonadherent (Cox and Snell R2 = 0.295, P = 0.0005).
Conclusion
Children newly diagnosed with JRA are more likely to adhere to an NSAID regimen if they have a greater number of active joints or their families have higher socioeconomic status. The former finding suggests that children's adherence is symptom‐driven, while the latter suggests that families of lower socioeconomic status deserve special attention to address adherence issues.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16342104</pmid><doi>10.1002/art.21603</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-3591 |
| ispartof | Arthritis and rheumatism, 2005-12, Vol.53 (6), p.905-910 |
| issn | 0004-3591 0893-7524 1529-0131 1529-0123 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68892885 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adherence Adolescent Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antirheumatic Agents - therapeutic use Arthritis, Juvenile - diagnosis Arthritis, Juvenile - drug therapy Arthritis, Juvenile - physiopathology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Child Child, Preschool Diseases of the osteoarticular system Drug Monitoring - methods Electronic monitoring Electronics Female Health Status Humans Inflammatory joint diseases Juvenile rheumatoid arthritis Male Medical sciences Nonsteroidal antiinflammatory drugs Patient Compliance Pharmacology. Drug treatments Severity of Illness Index Social Class |
| title | Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A27%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electronically%20monitored%20adherence%20to%20medications%20by%20newly%20diagnosed%20patients%20with%20juvenile%20rheumatoid%20arthritis&rft.jtitle=Arthritis%20and%20rheumatism&rft.au=Rapoff,%20Michael%20A.&rft.date=2005-12-15&rft.volume=53&rft.issue=6&rft.spage=905&rft.epage=910&rft.pages=905-910&rft.issn=0004-3591&rft.eissn=1529-0131&rft.coden=ARCREG&rft_id=info:doi/10.1002/art.21603&rft_dat=%3Cproquest_cross%3E68892885%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68892885&rft_id=info:pmid/16342104&rfr_iscdi=true |