No, It Is Not Possible to Be Schizophrenic Yet Neuropsychologically Normal
Cognitive impairment is well documented in schizophrenia, though some reports have been interpreted to suggest that it is possible to have schizophrenia without neuropsychological impairment. The authors tested this by comparing the neuropsychological profiles of closely matched patients with schizo...
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| Veröffentlicht in: | Neuropsychology 2005-11, Vol.19 (6), p.778-786 |
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| creator | Wilk, Christopher M Gold, James M McMahon, Robert P Humber, Katherine Iannone, Virginia N Buchanan, Robert W |
| description | Cognitive impairment is well documented in schizophrenia, though some reports have been interpreted to suggest that it is possible to have schizophrenia without neuropsychological impairment. The authors tested this by comparing the neuropsychological profiles of closely matched patients with schizophrenia and healthy comparison participants. Sixty-four patients with schizophrenia and 64 healthy comparison cases, matched to within 3 Full-Scale IQ points, were tested using the Wechsler Adult Intelligence Scale (3rd ed.;
D. Wechsler, 1997b
) and the Wechsler Memory Scale (3rd ed.;
D. Wechsler, 1997c
). Neuropsychological profiles for these groups were markedly different, with the group of patients with schizophrenia exhibiting performance deficits in memory and speeded visual processing but superior verbal comprehension and perceptual organization relative to the group of healthy comparison participants matched on Full-Scale IQ. Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness. |
| doi_str_mv | 10.1037/0894-4105.19.6.778 |
| format | Article |
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D. Wechsler, 1997b
) and the Wechsler Memory Scale (3rd ed.;
D. Wechsler, 1997c
). Neuropsychological profiles for these groups were markedly different, with the group of patients with schizophrenia exhibiting performance deficits in memory and speeded visual processing but superior verbal comprehension and perceptual organization relative to the group of healthy comparison participants matched on Full-Scale IQ. Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness.</description><identifier>ISSN: 0894-4105</identifier><identifier>EISSN: 1931-1559</identifier><identifier>DOI: 10.1037/0894-4105.19.6.778</identifier><identifier>PMID: 16351353</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Case-Control Studies ; Cognition Disorders - physiopathology ; Cognitive Ability ; Cognitive Impairment ; Cognitive Processing Speed ; Female ; Human ; Humans ; Intelligence ; Male ; Medical sciences ; Middle Aged ; Neuropsychological Tests - standards ; Neuropsychological Tests - statistics & numerical data ; Neuropsychology ; Psychiatric Status Rating Scales - statistics & numerical data ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Short Term Memory ; Verbal Behavior - physiology ; Wechsler Scales - statistics & numerical data</subject><ispartof>Neuropsychology, 2005-11, Vol.19 (6), p.778-786</ispartof><rights>2005 American Psychological Association</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2005 APA, all rights reserved.</rights><rights>2005, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a387t-8393590b0cbf76e0b232afb7e076b7255b7f579151367a0553f8ad54b45680b83</citedby><cites>FETCH-LOGICAL-a387t-8393590b0cbf76e0b232afb7e076b7255b7f579151367a0553f8ad54b45680b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17337815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16351353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilk, Christopher M</creatorcontrib><creatorcontrib>Gold, James M</creatorcontrib><creatorcontrib>McMahon, Robert P</creatorcontrib><creatorcontrib>Humber, Katherine</creatorcontrib><creatorcontrib>Iannone, Virginia N</creatorcontrib><creatorcontrib>Buchanan, Robert W</creatorcontrib><title>No, It Is Not Possible to Be Schizophrenic Yet Neuropsychologically Normal</title><title>Neuropsychology</title><addtitle>Neuropsychology</addtitle><description>Cognitive impairment is well documented in schizophrenia, though some reports have been interpreted to suggest that it is possible to have schizophrenia without neuropsychological impairment. The authors tested this by comparing the neuropsychological profiles of closely matched patients with schizophrenia and healthy comparison participants. Sixty-four patients with schizophrenia and 64 healthy comparison cases, matched to within 3 Full-Scale IQ points, were tested using the Wechsler Adult Intelligence Scale (3rd ed.;
D. Wechsler, 1997b
) and the Wechsler Memory Scale (3rd ed.;
D. Wechsler, 1997c
). Neuropsychological profiles for these groups were markedly different, with the group of patients with schizophrenia exhibiting performance deficits in memory and speeded visual processing but superior verbal comprehension and perceptual organization relative to the group of healthy comparison participants matched on Full-Scale IQ. Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognitive Ability</subject><subject>Cognitive Impairment</subject><subject>Cognitive Processing Speed</subject><subject>Female</subject><subject>Human</subject><subject>Humans</subject><subject>Intelligence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests - standards</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Neuropsychology</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Short Term Memory</subject><subject>Verbal Behavior - physiology</subject><subject>Wechsler Scales - statistics & numerical data</subject><issn>0894-4105</issn><issn>1931-1559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtP4zAURi3EiJbHH2CBLDSwmnTsOH4tGcSjCHVGAhasLNt1aJAbBztZlF8_rlpRiZWl6_PdxwHgFKMJRoT_RkJWRYURnWA5YRPOxR4YY0lwgSmV-2D8BYzAYUrvCOUCowdghBmhmFAyBg-z8AtOezhNcBZ6-C-k1BjvYB_gHwef7KL5DN0iurax8NX1cOaGGLq0sovgw1tjtfernIxL7Y_Bj1r75E627xF4ub15vr4vHv_eTa-vHgtNBO8LQSShEhlkTc2ZQ6Ykpa4Nd4gzw0tKDa8plzgvyLhGlJJa6DmtTEWZQEaQI3C56dvF8DG41Ktlk6zzXrcuDEkxISSSVZXB82_gexhim3dTDOd_UVY4Q-UGsjHfHl2tutgsdVwpjNRas1pbVGuLCkvFVNacQ2fbzoNZuvkusvWagYstoFN2VEfd2ibtOE4IF5hm7ueG051Wa6069o31LqnWDbt5_wHjKY78</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Wilk, Christopher M</creator><creator>Gold, James M</creator><creator>McMahon, Robert P</creator><creator>Humber, Katherine</creator><creator>Iannone, Virginia N</creator><creator>Buchanan, Robert W</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>No, It Is Not Possible to Be Schizophrenic Yet Neuropsychologically Normal</title><author>Wilk, Christopher M ; Gold, James M ; McMahon, Robert P ; Humber, Katherine ; Iannone, Virginia N ; Buchanan, Robert W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a387t-8393590b0cbf76e0b232afb7e076b7255b7f579151367a0553f8ad54b45680b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognitive Ability</topic><topic>Cognitive Impairment</topic><topic>Cognitive Processing Speed</topic><topic>Female</topic><topic>Human</topic><topic>Humans</topic><topic>Intelligence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests - standards</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Neuropsychology</topic><topic>Psychiatric Status Rating Scales - statistics & numerical data</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Short Term Memory</topic><topic>Verbal Behavior - physiology</topic><topic>Wechsler Scales - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilk, Christopher M</creatorcontrib><creatorcontrib>Gold, James M</creatorcontrib><creatorcontrib>McMahon, Robert P</creatorcontrib><creatorcontrib>Humber, Katherine</creatorcontrib><creatorcontrib>Iannone, Virginia N</creatorcontrib><creatorcontrib>Buchanan, Robert W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilk, Christopher M</au><au>Gold, James M</au><au>McMahon, Robert P</au><au>Humber, Katherine</au><au>Iannone, Virginia N</au><au>Buchanan, Robert W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No, It Is Not Possible to Be Schizophrenic Yet Neuropsychologically Normal</atitle><jtitle>Neuropsychology</jtitle><addtitle>Neuropsychology</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>19</volume><issue>6</issue><spage>778</spage><epage>786</epage><pages>778-786</pages><issn>0894-4105</issn><eissn>1931-1559</eissn><abstract>Cognitive impairment is well documented in schizophrenia, though some reports have been interpreted to suggest that it is possible to have schizophrenia without neuropsychological impairment. The authors tested this by comparing the neuropsychological profiles of closely matched patients with schizophrenia and healthy comparison participants. Sixty-four patients with schizophrenia and 64 healthy comparison cases, matched to within 3 Full-Scale IQ points, were tested using the Wechsler Adult Intelligence Scale (3rd ed.;
D. Wechsler, 1997b
) and the Wechsler Memory Scale (3rd ed.;
D. Wechsler, 1997c
). Neuropsychological profiles for these groups were markedly different, with the group of patients with schizophrenia exhibiting performance deficits in memory and speeded visual processing but superior verbal comprehension and perceptual organization relative to the group of healthy comparison participants matched on Full-Scale IQ. Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>16351353</pmid><doi>10.1037/0894-4105.19.6.778</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Case-Control Studies Cognition Disorders - physiopathology Cognitive Ability Cognitive Impairment Cognitive Processing Speed Female Human Humans Intelligence Male Medical sciences Middle Aged Neuropsychological Tests - standards Neuropsychological Tests - statistics & numerical data Neuropsychology Psychiatric Status Rating Scales - statistics & numerical data Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - physiopathology Schizophrenic Psychology Short Term Memory Verbal Behavior - physiology Wechsler Scales - statistics & numerical data |
| title | No, It Is Not Possible to Be Schizophrenic Yet Neuropsychologically Normal |
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