Examination of Two Independent Kinetic Assays for Determining the Inhibition of Carbonic Anhydrases I and II: Structure-Activity Comparison of Sulfamates and Sulfamides

Enzyme inhibition assays often require deviations from physiological conditions. For carbonic anhydrases, procedures involving native CO2 and non‐native substrates have been used. We compared a native and a non‐native substrate in the context of inhibition of human carbonic anhydrases I and II by ex...

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Veröffentlicht in:	Chemical biology & drug design 2006-08, Vol.68 (2), p.113-119
Hauptverfasser:	Shank, Richard P, McComsey, David F, Smith-Swintosky, Virginia L, Maryanoff, Bruce E
Format:	Artikel
Sprache:	eng
Schlagworte:	4-nitrophenylacetate hydrolysis carbonic anhydrase Carbonic Anhydrase I - antagonists & inhibitors Carbonic Anhydrase II - antagonists & inhibitors Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology CO2 hydration Kinetics Structure-Activity Relationship sulfamate sulfamide sulfonamide Sulfonic Acids - chemistry Sulfonic Acids - pharmacology
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