Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis

Recruitment of naturally occurring CD4+ CD25+ regulatory T (Treg) cells is a highly promising approach for the treatment of experimental autoimmune encephalomyelitis (EAE), a widely used model of multiple sclerosis. Here, we studied the in vivo interaction of Treg cells, induced by the monoclonal an...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2006-10, Vol.129 (10), p.2635-2647
Hauptverfasser:	Tischner, Denise, Weishaupt, Andreas, Brandt, Jens van den, Müller, Nora, Beyersdorf, Niklas, Ip, Chi Wang, Toyka, Klaus V., Hünig, Thomas, Gold, Ralf, Kerkau, Thomas, Reichardt, Holger M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Biological and medical sciences Blood-Brain Barrier CD28 Antigens - immunology cell migration Cell Movement Cell Proliferation CXCR-3 experimental autoimmune encephalomyelitis Flow Cytometry Immunization, Passive - methods Immunohistochemistry - methods Immunomodulators immunotherapy Interferon-gamma - immunology Lymphocyte Activation Medical sciences Microscopy, Confocal Models, Animal Multiple Sclerosis - immunology Multiple Sclerosis - therapy Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Pharmacology. Drug treatments Rats Rats, Inbred Lew Receptors, Chemokine - immunology Receptors, CXCR3 regulatory T cells Spinal Cord - immunology T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology
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