The Ferrous Verdoheme−Heme Oxygenase Complex is Six-Coordinate and Low-Spin

A biosynthetic and enzymatic method was developed for the preparation of 13C-labeled verdoheme, which permits the 13C NMR spectroscopic characterization of this elusive intermediate in the heme oxidation path catalyzed by the enzyme heme oxygenase. The 13C NMR data indicate that the ferrous verdohem...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-12, Vol.127 (50), p.17582-17583
Hauptverfasser:	Damaso, Christopher O, Bunce, Richard A, Barybin, Mikhail V, Wilks, Angela, Rivera, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbon Isotopes Ferrous Compounds - chemistry Fundamental and applied biological sciences. Psychology Heme - analogs & derivatives Heme - biosynthesis Heme - chemistry Heme Oxygenase (Decyclizing) - chemistry Heme Oxygenase (Decyclizing) - metabolism Interactions. Associations Intermolecular phenomena Isotope Labeling - methods Molecular biophysics Nuclear Magnetic Resonance, Biomolecular - methods Oxidation-Reduction
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