Apoptosis is reduced in the colonic mucosa of patients with acromegaly

Summary Background Patients with acromegaly have an increased risk of developing colonic tumours; reduced apoptosis is considered a leading mechanism in tumorigenesis. GH and IGF‐1 decrease apoptosis in several cell lines including human colonic adenocarcinoma, but it is unknown whether epithelial...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2005-12, Vol.63 (6), p.683-688
Hauptverfasser:	Bogazzi, Fausto, Russo, Dania, Locci, Maria Teresa, Chifenti, Barbara, Ultimieri, Federica, Raggi, Francesco, Cosci, Chiara, Sardella, Chiara, Costa, Aurelio, Gasperi, Maurizio, Bartalena, Luigi, Martino, Enio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - blood Acromegaly - pathology Adult Analysis of Variance Apoptosis Biological and medical sciences Blotting, Western - methods Colon Colonoscopy Cross-Sectional Studies Endocrinopathies Epithelial Cells - physiology Female Fundamental and applied biological sciences. Psychology Growth Hormone - blood Humans Hypothalamus. Hypophysis. Epiphysis (diseases) In Situ Nick-End Labeling Insulin-Like Growth Factor I - analysis Intestinal Mucosa - pathology Linear Models Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms PPAR gamma - genetics Reverse Transcriptase Polymerase Chain Reaction Vertebrates: endocrinology
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