The role of BRCA1 in transcriptional regulation and cell cycle control

The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the r...

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Veröffentlicht in:	Oncogene 2006-09, Vol.25 (43), p.5854-5863
Hauptverfasser:	Mullan, P B, Quinn, J E, Harkin, D P
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis BRCA1 protein BRCA1 Protein - genetics Cell Biology Cell cycle Cell Cycle - genetics Chromatin Chromatin - genetics Control DNA damage DNA repair Epigenetics Gene Expression Regulation Gene regulation Genes Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Mitosis - genetics Oncology Retinoblastoma Protein - genetics review RNA Polymerase III - metabolism STAT1 Transcription Factor - metabolism Transcription factors Transcription Factors - metabolism Transcription, Genetic Tumor Suppressor Protein p53 - metabolism Ubiquitin
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