Hepatitis C-associated autoimmunity in patients coinfected with HIV
: Background: Hepatitis C virus (HCV) infection is associated with multiple extrahepatic manifestations. It is unclear to what extent extrahepatic manifestations occur in HIV/HCV coinfection. Methods: We prospectively assessed cross‐sectional frequencies of autoimmune manifestations in HIV/HCV‐coinf...
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| Veröffentlicht in: | Liver international 2005-12, Vol.25 (6), p.1114-1121 |
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| creator | Woitas, Rainer P. Stoschus, Bodo Terjung, Birgit Vogel, Martin Kupfer, Bernd Brackmann, Hans H. Rockstroh, Jürgen K. Sauerbruch, Tilman Spengler, Ulrich |
| description | : Background: Hepatitis C virus (HCV) infection is associated with multiple extrahepatic manifestations. It is unclear to what extent extrahepatic manifestations occur in HIV/HCV coinfection.
Methods: We prospectively assessed cross‐sectional frequencies of autoimmune manifestations in HIV/HCV‐coinfected patients (n=98), HIV‐mono‐infected (n=45) and HCV‐mono‐infected patients (n=78). Diagnostic vasculitis scores, HCV and HIV loads, CD4 cell counts, thyroid‐, cardiolipin‐, non‐organ‐specific tissue antibodies (nuclear, smooth muscle, anti‐liver–kidney–microsome, neutrophil–cytoplasmic) and cryoglobulins were determined.
Results: Synergistic effects of HCV and HIV infection were observed with respect to the prevalence of antibodies against thyroglobulin (HCV infection 15.4%, HIV infection 8.8%, HIV/HCV coinfection 30.6%; P |
| doi_str_mv | 10.1111/j.1478-3231.2005.01159.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68888658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68888658</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4369-a045ab3d6d9675071d086e69673b9bd7a50ab7c8db792b2098fa3dd515ed79e23</originalsourceid><addsrcrecordid>eNqNkMtOwzAQRS0EolD4BZQVuwQ7jp14wQIFaCtFReLRSmwsJ3aESx4ldtT270lIVZYwmxlrzh1LBwAHQQ91dbPyUBBGLvYx8nwIiQcRIszbHoGzw-L4MPt4BM6NWUGIGCPoFIwQxQGGFJ6BeKrWwmqrjRO7wpg608Iq6YjW1ros20rbnaMrp4dUZY2T1brKVdYzG20_nOlscQFOclEYdbnvY_D2-PAaT93kaTKL7xI3CzBlroABESmWVDIaEhgiCSOqaPfAKUtlKAgUaZhFMg2Zn_qQRbnAUhJElAyZ8vEYXA9310391SpjealNpopCVKpuDadRV5REf4KIBX4AIe3AaACzpjamUTlfN7oUzY4jyHvTfMV7ibwXynvT_Mc033bRq_0fbVoq-Rvcq-2A2wHY6ELt_n2YJ7NFP3V5d8hrY9X2kBfNJ--MhYQv5xMevCfseb685y_4G5JXmxk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19424006</pqid></control><display><type>article</type><title>Hepatitis C-associated autoimmunity in patients coinfected with HIV</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Woitas, Rainer P. ; Stoschus, Bodo ; Terjung, Birgit ; Vogel, Martin ; Kupfer, Bernd ; Brackmann, Hans H. ; Rockstroh, Jürgen K. ; Sauerbruch, Tilman ; Spengler, Ulrich</creator><creatorcontrib>Woitas, Rainer P. ; Stoschus, Bodo ; Terjung, Birgit ; Vogel, Martin ; Kupfer, Bernd ; Brackmann, Hans H. ; Rockstroh, Jürgen K. ; Sauerbruch, Tilman ; Spengler, Ulrich</creatorcontrib><description>: Background: Hepatitis C virus (HCV) infection is associated with multiple extrahepatic manifestations. It is unclear to what extent extrahepatic manifestations occur in HIV/HCV coinfection.
Methods: We prospectively assessed cross‐sectional frequencies of autoimmune manifestations in HIV/HCV‐coinfected patients (n=98), HIV‐mono‐infected (n=45) and HCV‐mono‐infected patients (n=78). Diagnostic vasculitis scores, HCV and HIV loads, CD4 cell counts, thyroid‐, cardiolipin‐, non‐organ‐specific tissue antibodies (nuclear, smooth muscle, anti‐liver–kidney–microsome, neutrophil–cytoplasmic) and cryoglobulins were determined.
Results: Synergistic effects of HCV and HIV infection were observed with respect to the prevalence of antibodies against thyroglobulin (HCV infection 15.4%, HIV infection 8.8%, HIV/HCV coinfection 30.6%; P<0.001) and cardiolipin antibodies (HCV infection 9.0%, HIV infection 31%, HIV/HCV coinfection 46%; P<0.001). Cryoglobulinemia type III, was significantly associated with HCV infection (HCV, 25.6%; HIV/HCV, 20.4%) but not with HIV infection (4.4%, P<0.05). Rheumatoid factor was commonly detected in patients with HCV infection (48%), but occurred considerably less frequently in patients with HIV infection (4.4%) or HIV/HCV coinfection (9.5%, P<0.01).
Conclusion: HIV coinfection appears to differentially modulate the frequency of HCV‐related autoimmunity. However, autoimmunity is rarely accompanied by clinical manifestations.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/j.1478-3231.2005.01159.x</identifier><identifier>PMID: 16343060</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adult ; Aged ; Anti-Retroviral Agents - therapeutic use ; Antibodies, Anticardiolipin - blood ; Antiretroviral Therapy, Highly Active ; Autoantibodies - blood ; Autoimmune Diseases - complications ; autoimmunity ; cryoglobulinemia ; Cryoglobulinemia - complications ; Female ; HCV ; Hepatitis C - complications ; Hepatitis C - immunology ; Hepatitis C virus ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - immunology ; Human immunodeficiency virus ; Humans ; Male ; Middle Aged ; Rheumatoid Factor - blood ; Thyroglobulin - immunology</subject><ispartof>Liver international, 2005-12, Vol.25 (6), p.1114-1121</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4369-a045ab3d6d9675071d086e69673b9bd7a50ab7c8db792b2098fa3dd515ed79e23</citedby><cites>FETCH-LOGICAL-c4369-a045ab3d6d9675071d086e69673b9bd7a50ab7c8db792b2098fa3dd515ed79e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1478-3231.2005.01159.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1478-3231.2005.01159.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16343060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woitas, Rainer P.</creatorcontrib><creatorcontrib>Stoschus, Bodo</creatorcontrib><creatorcontrib>Terjung, Birgit</creatorcontrib><creatorcontrib>Vogel, Martin</creatorcontrib><creatorcontrib>Kupfer, Bernd</creatorcontrib><creatorcontrib>Brackmann, Hans H.</creatorcontrib><creatorcontrib>Rockstroh, Jürgen K.</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Spengler, Ulrich</creatorcontrib><title>Hepatitis C-associated autoimmunity in patients coinfected with HIV</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>: Background: Hepatitis C virus (HCV) infection is associated with multiple extrahepatic manifestations. It is unclear to what extent extrahepatic manifestations occur in HIV/HCV coinfection.
Methods: We prospectively assessed cross‐sectional frequencies of autoimmune manifestations in HIV/HCV‐coinfected patients (n=98), HIV‐mono‐infected (n=45) and HCV‐mono‐infected patients (n=78). Diagnostic vasculitis scores, HCV and HIV loads, CD4 cell counts, thyroid‐, cardiolipin‐, non‐organ‐specific tissue antibodies (nuclear, smooth muscle, anti‐liver–kidney–microsome, neutrophil–cytoplasmic) and cryoglobulins were determined.
Results: Synergistic effects of HCV and HIV infection were observed with respect to the prevalence of antibodies against thyroglobulin (HCV infection 15.4%, HIV infection 8.8%, HIV/HCV coinfection 30.6%; P<0.001) and cardiolipin antibodies (HCV infection 9.0%, HIV infection 31%, HIV/HCV coinfection 46%; P<0.001). Cryoglobulinemia type III, was significantly associated with HCV infection (HCV, 25.6%; HIV/HCV, 20.4%) but not with HIV infection (4.4%, P<0.05). Rheumatoid factor was commonly detected in patients with HCV infection (48%), but occurred considerably less frequently in patients with HIV infection (4.4%) or HIV/HCV coinfection (9.5%, P<0.01).
Conclusion: HIV coinfection appears to differentially modulate the frequency of HCV‐related autoimmunity. However, autoimmunity is rarely accompanied by clinical manifestations.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antibodies, Anticardiolipin - blood</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune Diseases - complications</subject><subject>autoimmunity</subject><subject>cryoglobulinemia</subject><subject>Cryoglobulinemia - complications</subject><subject>Female</subject><subject>HCV</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C virus</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Rheumatoid Factor - blood</subject><subject>Thyroglobulin - immunology</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EolD4BZQVuwQ7jp14wQIFaCtFReLRSmwsJ3aESx4ldtT270lIVZYwmxlrzh1LBwAHQQ91dbPyUBBGLvYx8nwIiQcRIszbHoGzw-L4MPt4BM6NWUGIGCPoFIwQxQGGFJ6BeKrWwmqrjRO7wpg608Iq6YjW1ros20rbnaMrp4dUZY2T1brKVdYzG20_nOlscQFOclEYdbnvY_D2-PAaT93kaTKL7xI3CzBlroABESmWVDIaEhgiCSOqaPfAKUtlKAgUaZhFMg2Zn_qQRbnAUhJElAyZ8vEYXA9310391SpjealNpopCVKpuDadRV5REf4KIBX4AIe3AaACzpjamUTlfN7oUzY4jyHvTfMV7ibwXynvT_Mc033bRq_0fbVoq-Rvcq-2A2wHY6ELt_n2YJ7NFP3V5d8hrY9X2kBfNJ--MhYQv5xMevCfseb685y_4G5JXmxk</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Woitas, Rainer P.</creator><creator>Stoschus, Bodo</creator><creator>Terjung, Birgit</creator><creator>Vogel, Martin</creator><creator>Kupfer, Bernd</creator><creator>Brackmann, Hans H.</creator><creator>Rockstroh, Jürgen K.</creator><creator>Sauerbruch, Tilman</creator><creator>Spengler, Ulrich</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200512</creationdate><title>Hepatitis C-associated autoimmunity in patients coinfected with HIV</title><author>Woitas, Rainer P. ; Stoschus, Bodo ; Terjung, Birgit ; Vogel, Martin ; Kupfer, Bernd ; Brackmann, Hans H. ; Rockstroh, Jürgen K. ; Sauerbruch, Tilman ; Spengler, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4369-a045ab3d6d9675071d086e69673b9bd7a50ab7c8db792b2098fa3dd515ed79e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-Retroviral Agents - therapeutic use</topic><topic>Antibodies, Anticardiolipin - blood</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune Diseases - complications</topic><topic>autoimmunity</topic><topic>cryoglobulinemia</topic><topic>Cryoglobulinemia - complications</topic><topic>Female</topic><topic>HCV</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C virus</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Rheumatoid Factor - blood</topic><topic>Thyroglobulin - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woitas, Rainer P.</creatorcontrib><creatorcontrib>Stoschus, Bodo</creatorcontrib><creatorcontrib>Terjung, Birgit</creatorcontrib><creatorcontrib>Vogel, Martin</creatorcontrib><creatorcontrib>Kupfer, Bernd</creatorcontrib><creatorcontrib>Brackmann, Hans H.</creatorcontrib><creatorcontrib>Rockstroh, Jürgen K.</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Spengler, Ulrich</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woitas, Rainer P.</au><au>Stoschus, Bodo</au><au>Terjung, Birgit</au><au>Vogel, Martin</au><au>Kupfer, Bernd</au><au>Brackmann, Hans H.</au><au>Rockstroh, Jürgen K.</au><au>Sauerbruch, Tilman</au><au>Spengler, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis C-associated autoimmunity in patients coinfected with HIV</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2005-12</date><risdate>2005</risdate><volume>25</volume><issue>6</issue><spage>1114</spage><epage>1121</epage><pages>1114-1121</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>: Background: Hepatitis C virus (HCV) infection is associated with multiple extrahepatic manifestations. It is unclear to what extent extrahepatic manifestations occur in HIV/HCV coinfection.
Methods: We prospectively assessed cross‐sectional frequencies of autoimmune manifestations in HIV/HCV‐coinfected patients (n=98), HIV‐mono‐infected (n=45) and HCV‐mono‐infected patients (n=78). Diagnostic vasculitis scores, HCV and HIV loads, CD4 cell counts, thyroid‐, cardiolipin‐, non‐organ‐specific tissue antibodies (nuclear, smooth muscle, anti‐liver–kidney–microsome, neutrophil–cytoplasmic) and cryoglobulins were determined.
Results: Synergistic effects of HCV and HIV infection were observed with respect to the prevalence of antibodies against thyroglobulin (HCV infection 15.4%, HIV infection 8.8%, HIV/HCV coinfection 30.6%; P<0.001) and cardiolipin antibodies (HCV infection 9.0%, HIV infection 31%, HIV/HCV coinfection 46%; P<0.001). Cryoglobulinemia type III, was significantly associated with HCV infection (HCV, 25.6%; HIV/HCV, 20.4%) but not with HIV infection (4.4%, P<0.05). Rheumatoid factor was commonly detected in patients with HCV infection (48%), but occurred considerably less frequently in patients with HIV infection (4.4%) or HIV/HCV coinfection (9.5%, P<0.01).
Conclusion: HIV coinfection appears to differentially modulate the frequency of HCV‐related autoimmunity. However, autoimmunity is rarely accompanied by clinical manifestations.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>16343060</pmid><doi>10.1111/j.1478-3231.2005.01159.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Anti-Retroviral Agents - therapeutic use Antibodies, Anticardiolipin - blood Antiretroviral Therapy, Highly Active Autoantibodies - blood Autoimmune Diseases - complications autoimmunity cryoglobulinemia Cryoglobulinemia - complications Female HCV Hepatitis C - complications Hepatitis C - immunology Hepatitis C virus HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Humans Male Middle Aged Rheumatoid Factor - blood Thyroglobulin - immunology |
| title | Hepatitis C-associated autoimmunity in patients coinfected with HIV |
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