Confocal microscopy: Imaging cervical precancerous lesions
We explore the clinical potential of reflectance and fluorescence confocal microscopy to image the morphologic and biochemical changes associated with precancer, in order to aid in the detection and diagnosis of cervical dysplasia. Cervical epithelial tissue samples imaged ex vivo or in vivo were ob...
Gespeichert in:
| Veröffentlicht in: | Gynecologic oncology 2005-12, Vol.99 (3), p.S84-S88 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S88 |
|---|---|
| container_issue | 3 |
| container_start_page | S84 |
| container_title | Gynecologic oncology |
| container_volume | 99 |
| creator | Carlson, Kristen Pavlova, Ina Collier, Tom Descour, Michael Follen, Michele Richards-Kortum, Rebecca |
| description | We explore the clinical potential of reflectance and fluorescence confocal microscopy to image the morphologic and biochemical changes associated with precancer, in order to aid in the detection and diagnosis of cervical dysplasia.
Cervical epithelial tissue samples imaged ex vivo or in vivo were obtained from M. D. Anderson Cancer Center and Lyndon B. Johnson Hospital in Houston, Texas. Confocal reflectance microscopy was used to image ex vivo cervical biopsies and in vivo cervical tissue. Confocal fluorescence microscopy was used to image ex vivo cervical tissue slices.
We present reflectance and fluorescence confocal images of cervical tissue demonstrating the ability to differentiate between normal and abnormal cervical tissue.
We believe that there is significant clinical potential for confocal microscopy to provide a sensitive and specific method for cervical precancer detection. |
| doi_str_mv | 10.1016/j.ygyno.2005.07.049 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68888398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0090825805005305</els_id><sourcerecordid>68888398</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-7ea164eeffd63b4a7f01737062a777631f394301c1de65140fc0f8621ed4dff83</originalsourceid><addsrcrecordid>eNp9kE1PwzAMhiMEYmPwC5DQTtxanKZN2kkc0MTHpElc4BxlqTNlapuSbEj996RsEjd8sSy_tl8_hNxSSClQ_rBLh-3QuTQDKFIQKeTVGZlSqIqEl0V1TqYAFSRlVpQTchXCDgAY0OySTCinOWOCT8li6TrjtGrmrdXeBe36YTFftWpru-1co_-2Y7P3qFUXS3cI8waDdV24JhdGNQFvTnlGPl-eP5Zvyfr9dbV8WieaFWKfCFSU54jG1JxtciUMUMEE8EwJITijhlV59KVpjbygORgNpuQZxTqvjSnZjNwf9_befR0w7GVrg8amUR1GO5KXMVg1CtlROD4SPBrZe9sqP0gKckQmd_IXmRyRSRAyIotTd6f1h02L9d_MiVEUPB4FGJ_8tuhl0BYjjNpGKntZO_vvgR8z5X4o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68888398</pqid></control><display><type>article</type><title>Confocal microscopy: Imaging cervical precancerous lesions</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Carlson, Kristen ; Pavlova, Ina ; Collier, Tom ; Descour, Michael ; Follen, Michele ; Richards-Kortum, Rebecca</creator><creatorcontrib>Carlson, Kristen ; Pavlova, Ina ; Collier, Tom ; Descour, Michael ; Follen, Michele ; Richards-Kortum, Rebecca</creatorcontrib><description>We explore the clinical potential of reflectance and fluorescence confocal microscopy to image the morphologic and biochemical changes associated with precancer, in order to aid in the detection and diagnosis of cervical dysplasia.
Cervical epithelial tissue samples imaged ex vivo or in vivo were obtained from M. D. Anderson Cancer Center and Lyndon B. Johnson Hospital in Houston, Texas. Confocal reflectance microscopy was used to image ex vivo cervical biopsies and in vivo cervical tissue. Confocal fluorescence microscopy was used to image ex vivo cervical tissue slices.
We present reflectance and fluorescence confocal images of cervical tissue demonstrating the ability to differentiate between normal and abnormal cervical tissue.
We believe that there is significant clinical potential for confocal microscopy to provide a sensitive and specific method for cervical precancer detection.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2005.07.049</identifier><identifier>PMID: 16143376</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biopsy ; Cervical cancer ; Cervical intraepithelial neoplasia ; Cervical Intraepithelial Neoplasia - diagnosis ; Cervical Intraepithelial Neoplasia - pathology ; Cervical precancer ; Clinical Trials as Topic ; Confocal microscopy ; Female ; Fiber Optic Technology ; Humans ; Microscopy, Confocal - instrumentation ; Microscopy, Confocal - methods ; Microscopy, Fluorescence - instrumentation ; Microscopy, Fluorescence - methods ; Pilot Projects ; Precancerous Conditions - diagnosis ; Precancerous Conditions - pathology ; Sensitivity and Specificity ; Squamous intraepithelial neoplasia ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Gynecologic oncology, 2005-12, Vol.99 (3), p.S84-S88</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-7ea164eeffd63b4a7f01737062a777631f394301c1de65140fc0f8621ed4dff83</citedby><cites>FETCH-LOGICAL-c357t-7ea164eeffd63b4a7f01737062a777631f394301c1de65140fc0f8621ed4dff83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygyno.2005.07.049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16143376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlson, Kristen</creatorcontrib><creatorcontrib>Pavlova, Ina</creatorcontrib><creatorcontrib>Collier, Tom</creatorcontrib><creatorcontrib>Descour, Michael</creatorcontrib><creatorcontrib>Follen, Michele</creatorcontrib><creatorcontrib>Richards-Kortum, Rebecca</creatorcontrib><title>Confocal microscopy: Imaging cervical precancerous lesions</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>We explore the clinical potential of reflectance and fluorescence confocal microscopy to image the morphologic and biochemical changes associated with precancer, in order to aid in the detection and diagnosis of cervical dysplasia.
Cervical epithelial tissue samples imaged ex vivo or in vivo were obtained from M. D. Anderson Cancer Center and Lyndon B. Johnson Hospital in Houston, Texas. Confocal reflectance microscopy was used to image ex vivo cervical biopsies and in vivo cervical tissue. Confocal fluorescence microscopy was used to image ex vivo cervical tissue slices.
We present reflectance and fluorescence confocal images of cervical tissue demonstrating the ability to differentiate between normal and abnormal cervical tissue.
We believe that there is significant clinical potential for confocal microscopy to provide a sensitive and specific method for cervical precancer detection.</description><subject>Biopsy</subject><subject>Cervical cancer</subject><subject>Cervical intraepithelial neoplasia</subject><subject>Cervical Intraepithelial Neoplasia - diagnosis</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervical precancer</subject><subject>Clinical Trials as Topic</subject><subject>Confocal microscopy</subject><subject>Female</subject><subject>Fiber Optic Technology</subject><subject>Humans</subject><subject>Microscopy, Confocal - instrumentation</subject><subject>Microscopy, Confocal - methods</subject><subject>Microscopy, Fluorescence - instrumentation</subject><subject>Microscopy, Fluorescence - methods</subject><subject>Pilot Projects</subject><subject>Precancerous Conditions - diagnosis</subject><subject>Precancerous Conditions - pathology</subject><subject>Sensitivity and Specificity</subject><subject>Squamous intraepithelial neoplasia</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEYmPwC5DQTtxanKZN2kkc0MTHpElc4BxlqTNlapuSbEj996RsEjd8sSy_tl8_hNxSSClQ_rBLh-3QuTQDKFIQKeTVGZlSqIqEl0V1TqYAFSRlVpQTchXCDgAY0OySTCinOWOCT8li6TrjtGrmrdXeBe36YTFftWpru-1co_-2Y7P3qFUXS3cI8waDdV24JhdGNQFvTnlGPl-eP5Zvyfr9dbV8WieaFWKfCFSU54jG1JxtciUMUMEE8EwJITijhlV59KVpjbygORgNpuQZxTqvjSnZjNwf9_befR0w7GVrg8amUR1GO5KXMVg1CtlROD4SPBrZe9sqP0gKckQmd_IXmRyRSRAyIotTd6f1h02L9d_MiVEUPB4FGJ_8tuhl0BYjjNpGKntZO_vvgR8z5X4o</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Carlson, Kristen</creator><creator>Pavlova, Ina</creator><creator>Collier, Tom</creator><creator>Descour, Michael</creator><creator>Follen, Michele</creator><creator>Richards-Kortum, Rebecca</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Confocal microscopy: Imaging cervical precancerous lesions</title><author>Carlson, Kristen ; Pavlova, Ina ; Collier, Tom ; Descour, Michael ; Follen, Michele ; Richards-Kortum, Rebecca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7ea164eeffd63b4a7f01737062a777631f394301c1de65140fc0f8621ed4dff83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biopsy</topic><topic>Cervical cancer</topic><topic>Cervical intraepithelial neoplasia</topic><topic>Cervical Intraepithelial Neoplasia - diagnosis</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervical precancer</topic><topic>Clinical Trials as Topic</topic><topic>Confocal microscopy</topic><topic>Female</topic><topic>Fiber Optic Technology</topic><topic>Humans</topic><topic>Microscopy, Confocal - instrumentation</topic><topic>Microscopy, Confocal - methods</topic><topic>Microscopy, Fluorescence - instrumentation</topic><topic>Microscopy, Fluorescence - methods</topic><topic>Pilot Projects</topic><topic>Precancerous Conditions - diagnosis</topic><topic>Precancerous Conditions - pathology</topic><topic>Sensitivity and Specificity</topic><topic>Squamous intraepithelial neoplasia</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlson, Kristen</creatorcontrib><creatorcontrib>Pavlova, Ina</creatorcontrib><creatorcontrib>Collier, Tom</creatorcontrib><creatorcontrib>Descour, Michael</creatorcontrib><creatorcontrib>Follen, Michele</creatorcontrib><creatorcontrib>Richards-Kortum, Rebecca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlson, Kristen</au><au>Pavlova, Ina</au><au>Collier, Tom</au><au>Descour, Michael</au><au>Follen, Michele</au><au>Richards-Kortum, Rebecca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Confocal microscopy: Imaging cervical precancerous lesions</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>99</volume><issue>3</issue><spage>S84</spage><epage>S88</epage><pages>S84-S88</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>We explore the clinical potential of reflectance and fluorescence confocal microscopy to image the morphologic and biochemical changes associated with precancer, in order to aid in the detection and diagnosis of cervical dysplasia.
Cervical epithelial tissue samples imaged ex vivo or in vivo were obtained from M. D. Anderson Cancer Center and Lyndon B. Johnson Hospital in Houston, Texas. Confocal reflectance microscopy was used to image ex vivo cervical biopsies and in vivo cervical tissue. Confocal fluorescence microscopy was used to image ex vivo cervical tissue slices.
We present reflectance and fluorescence confocal images of cervical tissue demonstrating the ability to differentiate between normal and abnormal cervical tissue.
We believe that there is significant clinical potential for confocal microscopy to provide a sensitive and specific method for cervical precancer detection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16143376</pmid><doi>10.1016/j.ygyno.2005.07.049</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-8258 |
| ispartof | Gynecologic oncology, 2005-12, Vol.99 (3), p.S84-S88 |
| issn | 0090-8258 1095-6859 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68888398 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biopsy Cervical cancer Cervical intraepithelial neoplasia Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - pathology Cervical precancer Clinical Trials as Topic Confocal microscopy Female Fiber Optic Technology Humans Microscopy, Confocal - instrumentation Microscopy, Confocal - methods Microscopy, Fluorescence - instrumentation Microscopy, Fluorescence - methods Pilot Projects Precancerous Conditions - diagnosis Precancerous Conditions - pathology Sensitivity and Specificity Squamous intraepithelial neoplasia Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology |
| title | Confocal microscopy: Imaging cervical precancerous lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T14%3A34%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Confocal%20microscopy:%20Imaging%20cervical%20precancerous%20lesions&rft.jtitle=Gynecologic%20oncology&rft.au=Carlson,%20Kristen&rft.date=2005-12-01&rft.volume=99&rft.issue=3&rft.spage=S84&rft.epage=S88&rft.pages=S84-S88&rft.issn=0090-8258&rft.eissn=1095-6859&rft_id=info:doi/10.1016/j.ygyno.2005.07.049&rft_dat=%3Cproquest_cross%3E68888398%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68888398&rft_id=info:pmid/16143376&rft_els_id=S0090825805005305&rfr_iscdi=true |