Chemical sympathectomy attenuates myenteric but not dorsal vagal complex Fos-like immunoreactivity induced by cholecystokinin-8 in the rat
Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8). The goal of this experiment is to test the role of the sympathetic nervous system in the pathway by which CCK-8 increases myenteric Fos-LI....
Gespeichert in:
| Veröffentlicht in: | Brain research 2005-12, Vol.1064 (1), p.119-125 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 125 |
|---|---|
| container_issue | 1 |
| container_start_page | 119 |
| container_title | Brain research |
| container_volume | 1064 |
| creator | Gulley, Stephen Raboin, Shannon J. Henley, Sheryce C. Chan, Wai-Chu Sharma, Sanjay K. Billups, Leonard H. Esdaile, Alton R. Sullivan, Cherese N. Moran, Timothy H. Sayegh, Ayman I. |
| description | Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8). The goal of this experiment is to test the role of the sympathetic nervous system in the pathway by which CCK-8 increases myenteric Fos-LI. Adult male Sprague–Dawley rats were pretreated with guanethidine sulfate (40 mg/kg daily for 5 weeks) or vehicle intraperitoneally (IP), and injected with CCK-8 (40 μg/kg) or saline IP. Fos-LI was then quantified in the DVC and the myenteric neurons of the duodenum and jejunum using a diaminobenzidine reaction. Guanethidine pretreatment attenuated myenteric but not DVC Fos-LI induced by CCK-8. These findings demonstrate that sympathetic neurons play a role in mediating the myenteric Fos-LI response to CCK. They also suggest differential mediation of myenteric and DVC responses to CCK. |
| doi_str_mv | 10.1016/j.brainres.2005.09.053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68888077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S000689930501348X</els_id><sourcerecordid>17462202</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-f8730bd9f8804e595166462341e6244420d9b87b78d12991abf22d224258a4f23</originalsourceid><addsrcrecordid>eNqFkc2OFCEQgInRuLOrr7Dhordu-ekfuGkmrmuyiRc9E5qudphtYAR6sv0KPrVMZswelwOkwldVUB9Ct5TUlNDu074eorY-QqoZIW1NZE1a_gptqOhZ1bGGvEYbQkhXCSn5FbpOaV9CziV5i65ox6TgLd2gv9sdOGv0jNPqDjrvwOTgVqxzBr_oDAm7FXyGaA0elox9yHgMMZWMo_5ddhPcYYYnfBdSNdtHwNa5xYcI2mR7tHnF1o-LgREPKza7MINZUw6P1ltfiXKJS1McdX6H3kx6TvD-ct6gX3dff27vq4cf375vvzxUpml5ribRczKMchKCNNDKlnZd0zHeUCjfbhpGRjmIfujFSJmUVA8TYyNjDWuFbibGb9DHc91DDH8WSFk5mwzMs_YQlqQ6URbp-xdB2pe-jJwqdmfQxJBShEkdonU6rooSddKl9uq_LnXSpYhURVdJvL10WAYH43PaxU8BPlwAnYqkKWpvbHrmes55y07c5zMHZXBHC1ElY8GXqdtYjKox2Jfe8g-ggbi7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17462202</pqid></control><display><type>article</type><title>Chemical sympathectomy attenuates myenteric but not dorsal vagal complex Fos-like immunoreactivity induced by cholecystokinin-8 in the rat</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Gulley, Stephen ; Raboin, Shannon J. ; Henley, Sheryce C. ; Chan, Wai-Chu ; Sharma, Sanjay K. ; Billups, Leonard H. ; Esdaile, Alton R. ; Sullivan, Cherese N. ; Moran, Timothy H. ; Sayegh, Ayman I.</creator><creatorcontrib>Gulley, Stephen ; Raboin, Shannon J. ; Henley, Sheryce C. ; Chan, Wai-Chu ; Sharma, Sanjay K. ; Billups, Leonard H. ; Esdaile, Alton R. ; Sullivan, Cherese N. ; Moran, Timothy H. ; Sayegh, Ayman I.</creatorcontrib><description>Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8). The goal of this experiment is to test the role of the sympathetic nervous system in the pathway by which CCK-8 increases myenteric Fos-LI. Adult male Sprague–Dawley rats were pretreated with guanethidine sulfate (40 mg/kg daily for 5 weeks) or vehicle intraperitoneally (IP), and injected with CCK-8 (40 μg/kg) or saline IP. Fos-LI was then quantified in the DVC and the myenteric neurons of the duodenum and jejunum using a diaminobenzidine reaction. Guanethidine pretreatment attenuated myenteric but not DVC Fos-LI induced by CCK-8. These findings demonstrate that sympathetic neurons play a role in mediating the myenteric Fos-LI response to CCK. They also suggest differential mediation of myenteric and DVC responses to CCK.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2005.09.053</identifier><identifier>PMID: 16298351</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Area postrema ; Biological and medical sciences ; C-Fos ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Chemical sympathectomy ; Cholecystokinin ; Cholecystokinin - physiology ; Dorsal vagal complex ; Enteric nervous system ; Fundamental and applied biological sciences. Psychology ; General aspects ; Guanethidine - pharmacology ; Guanethidine sulfate ; Immunohistochemistry ; Male ; Myenteric plexus ; Myenteric Plexus - drug effects ; Myenteric Plexus - metabolism ; NTS ; Peptide Fragments - physiology ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Rats, Sprague-Dawley ; Sympathectomy, Chemical ; Sympathetic Fibers, Postganglionic - drug effects ; Sympathetic Fibers, Postganglionic - metabolism ; Sympatholytics - pharmacology ; Vagotomy ; Vagus ; Vagus Nerve - drug effects ; Vagus Nerve - metabolism ; Vertebrates: digestive system ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2005-12, Vol.1064 (1), p.119-125</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-f8730bd9f8804e595166462341e6244420d9b87b78d12991abf22d224258a4f23</citedby><cites>FETCH-LOGICAL-c453t-f8730bd9f8804e595166462341e6244420d9b87b78d12991abf22d224258a4f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2005.09.053$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17333521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16298351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gulley, Stephen</creatorcontrib><creatorcontrib>Raboin, Shannon J.</creatorcontrib><creatorcontrib>Henley, Sheryce C.</creatorcontrib><creatorcontrib>Chan, Wai-Chu</creatorcontrib><creatorcontrib>Sharma, Sanjay K.</creatorcontrib><creatorcontrib>Billups, Leonard H.</creatorcontrib><creatorcontrib>Esdaile, Alton R.</creatorcontrib><creatorcontrib>Sullivan, Cherese N.</creatorcontrib><creatorcontrib>Moran, Timothy H.</creatorcontrib><creatorcontrib>Sayegh, Ayman I.</creatorcontrib><title>Chemical sympathectomy attenuates myenteric but not dorsal vagal complex Fos-like immunoreactivity induced by cholecystokinin-8 in the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8). The goal of this experiment is to test the role of the sympathetic nervous system in the pathway by which CCK-8 increases myenteric Fos-LI. Adult male Sprague–Dawley rats were pretreated with guanethidine sulfate (40 mg/kg daily for 5 weeks) or vehicle intraperitoneally (IP), and injected with CCK-8 (40 μg/kg) or saline IP. Fos-LI was then quantified in the DVC and the myenteric neurons of the duodenum and jejunum using a diaminobenzidine reaction. Guanethidine pretreatment attenuated myenteric but not DVC Fos-LI induced by CCK-8. These findings demonstrate that sympathetic neurons play a role in mediating the myenteric Fos-LI response to CCK. They also suggest differential mediation of myenteric and DVC responses to CCK.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Area postrema</subject><subject>Biological and medical sciences</subject><subject>C-Fos</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Chemical sympathectomy</subject><subject>Cholecystokinin</subject><subject>Cholecystokinin - physiology</subject><subject>Dorsal vagal complex</subject><subject>Enteric nervous system</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Guanethidine - pharmacology</subject><subject>Guanethidine sulfate</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Myenteric plexus</subject><subject>Myenteric Plexus - drug effects</subject><subject>Myenteric Plexus - metabolism</subject><subject>NTS</subject><subject>Peptide Fragments - physiology</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sympathectomy, Chemical</subject><subject>Sympathetic Fibers, Postganglionic - drug effects</subject><subject>Sympathetic Fibers, Postganglionic - metabolism</subject><subject>Sympatholytics - pharmacology</subject><subject>Vagotomy</subject><subject>Vagus</subject><subject>Vagus Nerve - drug effects</subject><subject>Vagus Nerve - metabolism</subject><subject>Vertebrates: digestive system</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEQgInRuLOrr7Dhordu-ekfuGkmrmuyiRc9E5qudphtYAR6sv0KPrVMZswelwOkwldVUB9Ct5TUlNDu074eorY-QqoZIW1NZE1a_gptqOhZ1bGGvEYbQkhXCSn5FbpOaV9CziV5i65ox6TgLd2gv9sdOGv0jNPqDjrvwOTgVqxzBr_oDAm7FXyGaA0elox9yHgMMZWMo_5ddhPcYYYnfBdSNdtHwNa5xYcI2mR7tHnF1o-LgREPKza7MINZUw6P1ltfiXKJS1McdX6H3kx6TvD-ct6gX3dff27vq4cf375vvzxUpml5ribRczKMchKCNNDKlnZd0zHeUCjfbhpGRjmIfujFSJmUVA8TYyNjDWuFbibGb9DHc91DDH8WSFk5mwzMs_YQlqQ6URbp-xdB2pe-jJwqdmfQxJBShEkdonU6rooSddKl9uq_LnXSpYhURVdJvL10WAYH43PaxU8BPlwAnYqkKWpvbHrmes55y07c5zMHZXBHC1ElY8GXqdtYjKox2Jfe8g-ggbi7</recordid><startdate>20051207</startdate><enddate>20051207</enddate><creator>Gulley, Stephen</creator><creator>Raboin, Shannon J.</creator><creator>Henley, Sheryce C.</creator><creator>Chan, Wai-Chu</creator><creator>Sharma, Sanjay K.</creator><creator>Billups, Leonard H.</creator><creator>Esdaile, Alton R.</creator><creator>Sullivan, Cherese N.</creator><creator>Moran, Timothy H.</creator><creator>Sayegh, Ayman I.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20051207</creationdate><title>Chemical sympathectomy attenuates myenteric but not dorsal vagal complex Fos-like immunoreactivity induced by cholecystokinin-8 in the rat</title><author>Gulley, Stephen ; Raboin, Shannon J. ; Henley, Sheryce C. ; Chan, Wai-Chu ; Sharma, Sanjay K. ; Billups, Leonard H. ; Esdaile, Alton R. ; Sullivan, Cherese N. ; Moran, Timothy H. ; Sayegh, Ayman I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-f8730bd9f8804e595166462341e6244420d9b87b78d12991abf22d224258a4f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Area postrema</topic><topic>Biological and medical sciences</topic><topic>C-Fos</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Chemical sympathectomy</topic><topic>Cholecystokinin</topic><topic>Cholecystokinin - physiology</topic><topic>Dorsal vagal complex</topic><topic>Enteric nervous system</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Guanethidine - pharmacology</topic><topic>Guanethidine sulfate</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Myenteric plexus</topic><topic>Myenteric Plexus - drug effects</topic><topic>Myenteric Plexus - metabolism</topic><topic>NTS</topic><topic>Peptide Fragments - physiology</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sympathectomy, Chemical</topic><topic>Sympathetic Fibers, Postganglionic - drug effects</topic><topic>Sympathetic Fibers, Postganglionic - metabolism</topic><topic>Sympatholytics - pharmacology</topic><topic>Vagotomy</topic><topic>Vagus</topic><topic>Vagus Nerve - drug effects</topic><topic>Vagus Nerve - metabolism</topic><topic>Vertebrates: digestive system</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gulley, Stephen</creatorcontrib><creatorcontrib>Raboin, Shannon J.</creatorcontrib><creatorcontrib>Henley, Sheryce C.</creatorcontrib><creatorcontrib>Chan, Wai-Chu</creatorcontrib><creatorcontrib>Sharma, Sanjay K.</creatorcontrib><creatorcontrib>Billups, Leonard H.</creatorcontrib><creatorcontrib>Esdaile, Alton R.</creatorcontrib><creatorcontrib>Sullivan, Cherese N.</creatorcontrib><creatorcontrib>Moran, Timothy H.</creatorcontrib><creatorcontrib>Sayegh, Ayman I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gulley, Stephen</au><au>Raboin, Shannon J.</au><au>Henley, Sheryce C.</au><au>Chan, Wai-Chu</au><au>Sharma, Sanjay K.</au><au>Billups, Leonard H.</au><au>Esdaile, Alton R.</au><au>Sullivan, Cherese N.</au><au>Moran, Timothy H.</au><au>Sayegh, Ayman I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical sympathectomy attenuates myenteric but not dorsal vagal complex Fos-like immunoreactivity induced by cholecystokinin-8 in the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2005-12-07</date><risdate>2005</risdate><volume>1064</volume><issue>1</issue><spage>119</spage><epage>125</epage><pages>119-125</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8). The goal of this experiment is to test the role of the sympathetic nervous system in the pathway by which CCK-8 increases myenteric Fos-LI. Adult male Sprague–Dawley rats were pretreated with guanethidine sulfate (40 mg/kg daily for 5 weeks) or vehicle intraperitoneally (IP), and injected with CCK-8 (40 μg/kg) or saline IP. Fos-LI was then quantified in the DVC and the myenteric neurons of the duodenum and jejunum using a diaminobenzidine reaction. Guanethidine pretreatment attenuated myenteric but not DVC Fos-LI induced by CCK-8. These findings demonstrate that sympathetic neurons play a role in mediating the myenteric Fos-LI response to CCK. They also suggest differential mediation of myenteric and DVC responses to CCK.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>16298351</pmid><doi>10.1016/j.brainres.2005.09.053</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2005-12, Vol.1064 (1), p.119-125 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68888077 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analysis of Variance Animals Area postrema Biological and medical sciences C-Fos Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Chemical sympathectomy Cholecystokinin Cholecystokinin - physiology Dorsal vagal complex Enteric nervous system Fundamental and applied biological sciences. Psychology General aspects Guanethidine - pharmacology Guanethidine sulfate Immunohistochemistry Male Myenteric plexus Myenteric Plexus - drug effects Myenteric Plexus - metabolism NTS Peptide Fragments - physiology Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Sympathectomy, Chemical Sympathetic Fibers, Postganglionic - drug effects Sympathetic Fibers, Postganglionic - metabolism Sympatholytics - pharmacology Vagotomy Vagus Vagus Nerve - drug effects Vagus Nerve - metabolism Vertebrates: digestive system Vertebrates: nervous system and sense organs |
| title | Chemical sympathectomy attenuates myenteric but not dorsal vagal complex Fos-like immunoreactivity induced by cholecystokinin-8 in the rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T04%3A46%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chemical%20sympathectomy%20attenuates%20myenteric%20but%20not%20dorsal%20vagal%20complex%20Fos-like%20immunoreactivity%20induced%20by%20cholecystokinin-8%20in%20the%20rat&rft.jtitle=Brain%20research&rft.au=Gulley,%20Stephen&rft.date=2005-12-07&rft.volume=1064&rft.issue=1&rft.spage=119&rft.epage=125&rft.pages=119-125&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/j.brainres.2005.09.053&rft_dat=%3Cproquest_cross%3E17462202%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17462202&rft_id=info:pmid/16298351&rft_els_id=S000689930501348X&rfr_iscdi=true |