Contribution of extracellular glutamine as an anaplerotic substrate to neuronal metabolism: a re-evaluation by multinuclear NMR spectroscopy in primary cultured neurons

Multinuclear NMR spectroscopy is used to investigate the effect of glutamine on neuronal glucose metabolism. Primary neurons were incubated with [1-(13C)]glucose in the absence or presence of glutamine (2 mM) and/or NH4Cl (5 mM). After ammonia-treatment, the concentrations of high-energy phosphates...

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Veröffentlicht in:	Neurochemical research 2005-10, Vol.30 (10), p.1269-1281
Hauptverfasser:	Shokati, Touraj, Zwingmann, Claudia, Leibfritz, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Chloride - metabolism Animals Carbon Radioisotopes - chemistry Carbon Radioisotopes - metabolism Cells, Cultured Citric Acid Cycle - physiology Culture Media - chemistry Energy Metabolism Glucose - chemistry Glucose - metabolism Glutamine - metabolism Neurons - cytology Neurons - metabolism Nuclear Magnetic Resonance, Biomolecular Rats
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